Click here to switch to the map view.

The map label for this gene is melC2 [H]

Identifier: 82703275

GI number: 82703275

Start: 2450361

End: 2451848

Strand: Reverse

Name: melC2 [H]

Synonym: Nmul_A2156

Alternate gene names: 82703275

Gene position: 2451848-2450361 (Counterclockwise)

Preceding gene: 82703276

Following gene: 82703274

Centisome position: 77.0

GC content: 57.59

Gene sequence:

>1488_bases
ATGGGAACCCGAAAGAATCAATCCACGTTGACAGCCGCGGAGAAGGCGGCCTTTGTTGGGGCGGTAAAAGCACTCAAGGC
AAATGGCTCCTATGATGTATTCGTGGCCCAGCACCGTACCGCCTTTCTTGCCGGCGTGAACGATCCGGCACATGGCGGTC
CTGCCTTTCTGCCTTGGCACAGGGAGTATCTCCGCCGGTTCGAGCGTGCCCTTCAGCAGATCGATCCCAGTGTTTCCATC
CCCTATTGGGACTGGACAGTTGATCGCACGACGAATGCTTCCATCTGGAATGCGAATTTCATGGGTGGAAATGGAACGGG
CCCCGGCGGACGCGTGATGACGGGGCCGTTCGCCTTTTCCACGGGAGAGTGGACGCTTACTGTTCTGGACCCCGGTGACA
CGGATAATTTTCTCACCCGTGCCTTCGGCGCCATGGGAGCGTTGCCCACCCAACAGGGAGTGAATGCCGCCATCAATATC
GTGCCCTATGATTCAGCGCCCTGGAATCGTAACAGCAGCATGAATACGAGTTTTCGAAACCATCTCGAGGGGATTATCCA
CAATCCCGGCCACATGTGGGTAGGCGGCTCGATGATGGCTATGTCCTCCCCCAACGATCCGGTGTTCTGGCTGCATCATT
GCAATATCGATCGGTTATGGGCAGTATGGCAGCGGGAAAATCCGGGGCAGAATTATCGTCCGCCGAGCGGCACGGCGGGC
GTGGTGAACGGCCATGGACTGGATGACCCGATGCCGCCCTGGAACAACGAAGCTTCGCCGCCTACGCCCCGGGATGTTCT
CGATCACCATGCGCTTGGCTACACGTACGATGACGAGGAAGAAGAACCTCCGCAGATCGTACCCCTGACCCTTGATGCGG
CTCCGTTTGCCGCTTCCATAGGCCAGGCGGGAGAAGTGGACACATATAGCTTCGTTGCCTCAAGCCAGGGGAATTATATT
ATCGAAACCGAGGGTTCCACCGATGTAGTGGCCGCCCTGTATGGTCCGGATGATGCCAATGCGCTCGTTGCCGAGGATGA
CGACAGCGGCGTCGGCCGGAATCCGCGCATTGCACGAGACCTGGCGCCGGGAACATACTATGTTCGCATAAGGCACTATA
GCGGCTCATCCACTGGAAGCTACCGTATTTCAGTACGAGGGTCAGGAGGCCCGCAGCCGGGTATCCAGACCATTCAGATA
AATGGTCCGGCAGTGCAGGGCACACTCTCCGCCAATGAGAGGGATCTGTACACCTTTACTGTCAGCACGTCCGGCTCCCA
TACGATAGAAACCGCTGGTAGCACTGATTGCTTCCTCACGTTATTCGGCCCCGACAGCCAGACTGCCGTCATTGCCCAGG
ATGACGACAGTGGCCCGGGAACCAATTCGCGCATCGTGCAAAACCTCGGGGCCGGTGTCTATTATGTTCAGGTCAGGCAT
TACAGCCCGACCGGTACAGGGGCGTATAGTGTTTCCGTCAGAACATGA

Upstream 100 bases:

>100_bases
CCGGCTCGTATATCGCCTCCGGCTTCGCTTTCGATCCGCAACCTTCGCCTATGGACTTGGCGCGGAAAATTATCGATTAC
CGTGAGGCGGGGAGATAAAA

Downstream 100 bases:

>100_bases
AAGGAAATGCGGGCGGGATTCTCTTGATTTCCTGACGGTTGGCCTCGGTGAAAAGCGTTCTGGCACTCGTCGTTCTTCTT
GCCGGCTGCGGCTCGATAAT

Product: tyrosinase/peptidase

Products: NA

Alternate protein names: Monophenol monooxygenase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MGTRKNQSTLTAAEKAAFVGAVKALKANGSYDVFVAQHRTAFLAGVNDPAHGGPAFLPWHREYLRRFERALQQIDPSVSI
PYWDWTVDRTTNASIWNANFMGGNGTGPGGRVMTGPFAFSTGEWTLTVLDPGDTDNFLTRAFGAMGALPTQQGVNAAINI
VPYDSAPWNRNSSMNTSFRNHLEGIIHNPGHMWVGGSMMAMSSPNDPVFWLHHCNIDRLWAVWQRENPGQNYRPPSGTAG
VVNGHGLDDPMPPWNNEASPPTPRDVLDHHALGYTYDDEEEEPPQIVPLTLDAAPFAASIGQAGEVDTYSFVASSQGNYI
IETEGSTDVVAALYGPDDANALVAEDDDSGVGRNPRIARDLAPGTYYVRIRHYSGSSTGSYRISVRGSGGPQPGIQTIQI
NGPAVQGTLSANERDLYTFTVSTSGSHTIETAGSTDCFLTLFGPDSQTAVIAQDDDSGPGTNSRIVQNLGAGVYYVQVRH
YSPTGTGAYSVSVRT

Sequences:

>Translated_495_residues
MGTRKNQSTLTAAEKAAFVGAVKALKANGSYDVFVAQHRTAFLAGVNDPAHGGPAFLPWHREYLRRFERALQQIDPSVSI
PYWDWTVDRTTNASIWNANFMGGNGTGPGGRVMTGPFAFSTGEWTLTVLDPGDTDNFLTRAFGAMGALPTQQGVNAAINI
VPYDSAPWNRNSSMNTSFRNHLEGIIHNPGHMWVGGSMMAMSSPNDPVFWLHHCNIDRLWAVWQRENPGQNYRPPSGTAG
VVNGHGLDDPMPPWNNEASPPTPRDVLDHHALGYTYDDEEEEPPQIVPLTLDAAPFAASIGQAGEVDTYSFVASSQGNYI
IETEGSTDVVAALYGPDDANALVAEDDDSGVGRNPRIARDLAPGTYYVRIRHYSGSSTGSYRISVRGSGGPQPGIQTIQI
NGPAVQGTLSANERDLYTFTVSTSGSHTIETAGSTDCFLTLFGPDSQTAVIAQDDDSGPGTNSRIVQNLGAGVYYVQVRH
YSPTGTGAYSVSVRT
>Mature_494_residues
GTRKNQSTLTAAEKAAFVGAVKALKANGSYDVFVAQHRTAFLAGVNDPAHGGPAFLPWHREYLRRFERALQQIDPSVSIP
YWDWTVDRTTNASIWNANFMGGNGTGPGGRVMTGPFAFSTGEWTLTVLDPGDTDNFLTRAFGAMGALPTQQGVNAAINIV
PYDSAPWNRNSSMNTSFRNHLEGIIHNPGHMWVGGSMMAMSSPNDPVFWLHHCNIDRLWAVWQRENPGQNYRPPSGTAGV
VNGHGLDDPMPPWNNEASPPTPRDVLDHHALGYTYDDEEEEPPQIVPLTLDAAPFAASIGQAGEVDTYSFVASSQGNYII
ETEGSTDVVAALYGPDDANALVAEDDDSGVGRNPRIARDLAPGTYYVRIRHYSGSSTGSYRISVRGSGGPQPGIQTIQIN
GPAVQGTLSANERDLYTFTVSTSGSHTIETAGSTDCFLTLFGPDSQTAVIAQDDDSGPGTNSRIVQNLGAGVYYVQVRHY
SPTGTGAYSVSVRT

Specific function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tyrosinase family [H]

Homologues:

Organism=Homo sapiens, GI4507753, Length=323, Percent_Identity=28.1733746130031, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17554098, Length=239, Percent_Identity=36.4016736401674, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193202602, Length=233, Percent_Identity=33.4763948497854, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17505853, Length=267, Percent_Identity=35.2059925093633, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17551924, Length=268, Percent_Identity=30.9701492537313, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71999521, Length=214, Percent_Identity=35.0467289719626, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI115533628, Length=265, Percent_Identity=26.0377358490566, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008922
- InterPro:   IPR002227 [H]

Pfam domain/function: PF00264 Tyrosinase [H]

EC number: =1.14.18.1 [H]

Molecular weight: Translated: 53203; Mature: 53072

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00497 TYROSINASE_1 ; PS00498 TYROSINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTRKNQSTLTAAEKAAFVGAVKALKANGSYDVFVAQHRTAFLAGVNDPAHGGPAFLPWH
CCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEECCEEEEEECCCCCCCCCCCCCHH
REYLRRFERALQQIDPSVSIPYWDWTVDRTTNASIWNANFMGGNGTGPGGRVMTGPFAFS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCEEECCEEEE
TGEWTLTVLDPGDTDNFLTRAFGAMGALPTQQGVNAAINIVPYDSAPWNRNSSMNTSFRN
CCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHH
HLEGIIHNPGHMWVGGSMMAMSSPNDPVFWLHHCNIDRLWAVWQRENPGQNYRPPSGTAG
HHHHEEECCCCEEECCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEE
VVNGHGLDDPMPPWNNEASPPTPRDVLDHHALGYTYDDEEEEPPQIVPLTLDAAPFAASI
EEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEECCCCCCCCCEEEEEECCCCHHHHC
GQAGEVDTYSFVASSQGNYIIETEGSTDVVAALYGPDDANALVAEDDDSGVGRNPRIARD
CCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHH
LAPGTYYVRIRHYSGSSTGSYRISVRGSGGPQPGIQTIQINGPAVQGTLSANERDLYTFT
CCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCEEEEEE
VSTSGSHTIETAGSTDCFLTLFGPDSQTAVIAQDDDSGPGTNSRIVQNLGAGVYYVQVRH
EECCCCEEEEECCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEEEEEE
YSPTGTGAYSVSVRT
ECCCCCCEEEEEEEC
>Mature Secondary Structure 
GTRKNQSTLTAAEKAAFVGAVKALKANGSYDVFVAQHRTAFLAGVNDPAHGGPAFLPWH
CCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEECCEEEEEECCCCCCCCCCCCCHH
REYLRRFERALQQIDPSVSIPYWDWTVDRTTNASIWNANFMGGNGTGPGGRVMTGPFAFS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCEEECCEEEE
TGEWTLTVLDPGDTDNFLTRAFGAMGALPTQQGVNAAINIVPYDSAPWNRNSSMNTSFRN
CCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHH
HLEGIIHNPGHMWVGGSMMAMSSPNDPVFWLHHCNIDRLWAVWQRENPGQNYRPPSGTAG
HHHHEEECCCCEEECCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCEE
VVNGHGLDDPMPPWNNEASPPTPRDVLDHHALGYTYDDEEEEPPQIVPLTLDAAPFAASI
EEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEECCCCCCCCCEEEEEECCCCHHHHC
GQAGEVDTYSFVASSQGNYIIETEGSTDVVAALYGPDDANALVAEDDDSGVGRNPRIARD
CCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCHHHH
LAPGTYYVRIRHYSGSSTGSYRISVRGSGGPQPGIQTIQINGPAVQGTLSANERDLYTFT
CCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCEEEEEE
VSTSGSHTIETAGSTDCFLTLFGPDSQTAVIAQDDDSGPGTNSRIVQNLGAGVYYVQVRH
EECCCCEEEEECCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEEEEEE
YSPTGTGAYSVSVRT
ECCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3002431; 2846043; 1901488 [H]