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The map label for this gene is coaBC [H]

Identifier: 82703256

GI number: 82703256

Start: 2430393

End: 2431628

Strand: Reverse

Name: coaBC [H]

Synonym: Nmul_A2137

Alternate gene names: 82703256

Gene position: 2431628-2430393 (Counterclockwise)

Preceding gene: 82703260

Following gene: 82703255

Centisome position: 76.36

GC content: 56.07

Gene sequence:

>1236_bases
GTGATTCGGTTGAAGACGACTGGCAGGACGCCCGAGGCAAGACGCGTGCTTTTGGGACTCACGGGGGGAGTTGCGGCATA
CAAGGCGGCAGAACTGGTGCGCCTTTTGATAAGCGGGGGCATGGAGGTGCAGGCAGTCATGACGGCGTCAGCCTGCCGTT
TTGTCGGTACGGCCACGCTACAGGCCTTGACCGGCAAGCCCGTATTTACCGAGCTGTGGGATGCCAGCGTAGCCAACAAC
ATGGCTCATATCGACCTTTCGCGCAACGTCGATGCTATTGTCATTTCCCCCGCCAGCGCCGACTTTATTGCCAAGGTTGC
CCACGGCCTCGCGGATGACCTGCTCTCCACATTATGCCTTGCGCGCGCATGCCCCTTGCTGATTGCTCCCGCAATGAATC
GGCAGATGTGGGAAAATTCCGCCACCCGTCGCAATCTCGACACGTTGCGCGGGGATGGCGTGACAGTGCTGGGTCCTGCC
AGCGGCGTGCAGGCGTGTGGCGAAACCGGCATGGGACGCATGCTCGAAGCGCATGAACTCGCGGAAGCGGTACACGCTTT
TTTTCAACCCAAACTGCTGCATACCAAGCGCGTACTCATCACTGCCGGACCTACCTTCGAAGCAATCGATGCGGTTCGCG
GGATAACCAATTCAAGTTCCGGCAAAATGGGGTATGCAGTGGCGCGTGCCGCAGCCGAGGCAGGAGCGGAAGTAATCCTC
GTATCCGGGCCGGTTTGCCTGGAAGCGCCACCGCGCGCTCGCCTCATCAAGGTGACAAGCGCGCAGGATATGCTGATAGC
CGTAAAAAGCGAAGTTCAACAGGTTCAACAAGTCGATTTTTTTATAAGCGTCGCTGCCGTGGCTGACTATCGTCCCAAAA
ATGCCAGCGAACACAAAACGAAAAAGAATGACAGCAATATCATCCTGGAGCTTGTTCCCAATCCTGATATTCTTGAATAC
GTGGCAAATCTGCCGGATCCGCCGTTTTGCATCGGTTTTGCTGCGGAGACCCAAAATCTGGAAGAGAATGCCGAAGCCAA
GCGCCGTCGGAAAAAGCTTCCACTTCTTGCTGCCAATCTCGCCCAGGAGGCGATAGGTGCGGAGGAAGTTGCGTTGACGC
TCTTCGATGATTCCGGCAGGCATTCCTTGCCAAAATCGTCGAAAATCGAACAGGCGCGGCACCTCATCGCTCATGCAGCA
TCGCTTTATGAAAAATGGCGGAATTTTAATTCATGA

Upstream 100 bases:

>100_bases
TTAAACGTCAGTTTGTGAAAAAACTGTAGCTGAAGAATATATCGCCCGTAAAGCGGTGCGGGTTTTGGGAGTATTGAGTT
AGACTCCTCTTTTTTAGGGA

Downstream 100 bases:

>100_bases
AAAAAATAGATATAAAAATTCTCGATTCGCGCCTGAAAGATCAGTTGCCCGCCTATGCGACCTCCGGCTCCGCCGGCCTC
GACTTGCGCGCGTGCATCGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MIRLKTTGRTPEARRVLLGLTGGVAAYKAAELVRLLISGGMEVQAVMTASACRFVGTATLQALTGKPVFTELWDASVANN
MAHIDLSRNVDAIVISPASADFIAKVAHGLADDLLSTLCLARACPLLIAPAMNRQMWENSATRRNLDTLRGDGVTVLGPA
SGVQACGETGMGRMLEAHELAEAVHAFFQPKLLHTKRVLITAGPTFEAIDAVRGITNSSSGKMGYAVARAAAEAGAEVIL
VSGPVCLEAPPRARLIKVTSAQDMLIAVKSEVQQVQQVDFFISVAAVADYRPKNASEHKTKKNDSNIILELVPNPDILEY
VANLPDPPFCIGFAAETQNLEENAEAKRRRKKLPLLAANLAQEAIGAEEVALTLFDDSGRHSLPKSSKIEQARHLIAHAA
SLYEKWRNFNS

Sequences:

>Translated_411_residues
MIRLKTTGRTPEARRVLLGLTGGVAAYKAAELVRLLISGGMEVQAVMTASACRFVGTATLQALTGKPVFTELWDASVANN
MAHIDLSRNVDAIVISPASADFIAKVAHGLADDLLSTLCLARACPLLIAPAMNRQMWENSATRRNLDTLRGDGVTVLGPA
SGVQACGETGMGRMLEAHELAEAVHAFFQPKLLHTKRVLITAGPTFEAIDAVRGITNSSSGKMGYAVARAAAEAGAEVIL
VSGPVCLEAPPRARLIKVTSAQDMLIAVKSEVQQVQQVDFFISVAAVADYRPKNASEHKTKKNDSNIILELVPNPDILEY
VANLPDPPFCIGFAAETQNLEENAEAKRRRKKLPLLAANLAQEAIGAEEVALTLFDDSGRHSLPKSSKIEQARHLIAHAA
SLYEKWRNFNS
>Mature_411_residues
MIRLKTTGRTPEARRVLLGLTGGVAAYKAAELVRLLISGGMEVQAVMTASACRFVGTATLQALTGKPVFTELWDASVANN
MAHIDLSRNVDAIVISPASADFIAKVAHGLADDLLSTLCLARACPLLIAPAMNRQMWENSATRRNLDTLRGDGVTVLGPA
SGVQACGETGMGRMLEAHELAEAVHAFFQPKLLHTKRVLITAGPTFEAIDAVRGITNSSSGKMGYAVARAAAEAGAEVIL
VSGPVCLEAPPRARLIKVTSAQDMLIAVKSEVQQVQQVDFFISVAAVADYRPKNASEHKTKKNDSNIILELVPNPDILEY
VANLPDPPFCIGFAAETQNLEENAEAKRRRKKLPLLAANLAQEAIGAEEVALTLFDDSGRHSLPKSSKIEQARHLIAHAA
SLYEKWRNFNS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=187, Percent_Identity=35.2941176470588, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=43.3915211970075, Blast_Score=286, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=172, Percent_Identity=29.6511627906977, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322762, Length=188, Percent_Identity=30.8510638297872, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24657262, Length=193, Percent_Identity=33.160621761658, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44075; Mature: 44075

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLKTTGRTPEARRVLLGLTGGVAAYKAAELVRLLISGGMEVQAVMTASACRFVGTATL
CEEEECCCCCHHHHEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
QALTGKPVFTELWDASVANNMAHIDLSRNVDAIVISPASADFIAKVAHGLADDLLSTLCL
HHHCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ARACPLLIAPAMNRQMWENSATRRNLDTLRGDGVTVLGPASGVQACGETGMGRMLEAHEL
HHHCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCHHHHHHCCCCHHHHHHHHHH
AEAVHAFFQPKLLHTKRVLITAGPTFEAIDAVRGITNSSSGKMGYAVARAAAEAGAEVIL
HHHHHHHHCCHHHCCEEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEE
VSGPVCLEAPPRARLIKVTSAQDMLIAVKSEVQQVQQVDFFISVAAVADYRPKNASEHKT
EECCEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCC
KKNDSNIILELVPNPDILEYVANLPDPPFCIGFAAETQNLEENAEAKRRRKKLPLLAANL
CCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEEEHHHCCCHHHHHHHHHHHCCCHHHHHH
AQEAIGAEEVALTLFDDSGRHSLPKSSKIEQARHLIAHAASLYEKWRNFNS
HHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRLKTTGRTPEARRVLLGLTGGVAAYKAAELVRLLISGGMEVQAVMTASACRFVGTATL
CEEEECCCCCHHHHEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
QALTGKPVFTELWDASVANNMAHIDLSRNVDAIVISPASADFIAKVAHGLADDLLSTLCL
HHHCCCCHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ARACPLLIAPAMNRQMWENSATRRNLDTLRGDGVTVLGPASGVQACGETGMGRMLEAHEL
HHHCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCHHHHHHCCCCHHHHHHHHHH
AEAVHAFFQPKLLHTKRVLITAGPTFEAIDAVRGITNSSSGKMGYAVARAAAEAGAEVIL
HHHHHHHHCCHHHCCEEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEE
VSGPVCLEAPPRARLIKVTSAQDMLIAVKSEVQQVQQVDFFISVAAVADYRPKNASEHKT
EECCEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCC
KKNDSNIILELVPNPDILEYVANLPDPPFCIGFAAETQNLEENAEAKRRRKKLPLLAANL
CCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEEEHHHCCCHHHHHHHHHHHCCCHHHHHH
AQEAIGAEEVALTLFDDSGRHSLPKSSKIEQARHLIAHAASLYEKWRNFNS
HHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]