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The map label for this gene is dacC [H]

Identifier: 82703112

GI number: 82703112

Start: 2287557

End: 2288771

Strand: Reverse

Name: dacC [H]

Synonym: Nmul_A1991

Alternate gene names: 82703112

Gene position: 2288771-2287557 (Counterclockwise)

Preceding gene: 82703113

Following gene: 82703111

Centisome position: 71.88

GC content: 54.65

Gene sequence:

>1215_bases
TTGACTGATTCAGAAGCCCGGCGGATAACGTCTTCGATATGGCTGGGATATAATAACGCTTTTTTGCAGATCGCCATGAG
ACGCTTGCTTCCTATATCGCTGTGTCTGCTTGCCCTGCCACTGGCTGCTCAACAACCCCAGTTTCACGCGCCGCCGCAAA
CTCTCTCCGTCGCCGCCAAGTCTTATATACTTGCCGATCTTCAGAGCGGACAGGTGCTTGTGAGCAAGAATGCCCATGAA
CGCGTCGATCCGGCATCGCTGACAAAGCTGATGACGGCTTATGTGGTTTTTGCAGCTCTGTATCAGAAACGTGTCACCTT
GACGCAGGCTGTGCCAGTCTCGACACGTGCCTGGCGGGCGCAAGGCTCCCGCATGTTCATCGAGCCGAAGAAGCCCGTGA
CGGTCGATGAATTGATGCGCGGCATGATCGTGCAGTCAGGAAACGACGCCTCCATTGCACTGGCGGAGGCCGTTTCAGGA
TCAGAGGAGGCATTCGCTCAAGCGATGAACAAGGAGGCGGCGCGCATGGGCATGAAGAACACCCGTTTTGCCAATTCAAC
CGGACTTCCGGACCCGGACCATTACACCACCGCGTACGATCTCGCCTTGCTCGCAACCGCCATCATTCGCGATTTTCCGG
AATATTATCCACTCTATTCCCTCAAGGAATATACCTATAACAAAATTACTCAGGCGAACCGGAACCGCCTGCTCTGGCTC
GACCCGAATGTCGACGGGATGAAGACGGGACACACTGACGCAGCCGGTTACTGCCTCATTACTTCAGCCAGGCGGGGACA
GCGTCGGTTGGTTGCGGTAGTGATGGGAACCGCCTCGGAGAGCGCGCGCGCGATGGAAAGCCAGCGCCTGCTGAATTATG
GTTTTCAGTTCTACGATACGGTTCGTCTCTATCCGGGAGAGCAGGAGGTGGTTGCCATTCCATTATGGAAAGGCAACCAG
GACAAACTCAGGACGGGATTCGGAAATGATGTTTATTTTTCGCTTCCCCGCCATCAGACTGACAAACTCAAGGCCAGGAT
GGAATATAAGCAGCCGCTTCTCGCTCCTGTCGCTGCGGGCCAAAAAGTTGGTACAGTGAAGTTTATGCTCGAAGGGAAGC
AGGTGGTTGAACATCCGCTGGTAGCGCTCGAAACCGTCAGCGCTGCGAATATTTTTGGCCGGGCATGGGATAGCATGCGG
CTTCTATTTAACTAG

Upstream 100 bases:

>100_bases
GCGCCGAAAAATAGGATCGGAAAGTCCATTCGCATCGGAGCATTTCTAATTCGTCTGTCTTGCTGAAGAGACATGGCGGC
CTGCAGCCGCGGGATAACCT

Downstream 100 bases:

>100_bases
AAGCAAAAACCCGAGCTATCCAGGCTGATCATGATCTATCTAAACGGCGATTTCCTGAGAATCGAAGAAGCGCGCATCTC
TGTGCTGGATAGAGGTTTTA

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTDSEARRITSSIWLGYNNAFLQIAMRRLLPISLCLLALPLAAQQPQFHAPPQTLSVAAKSYILADLQSGQVLVSKNAHE
RVDPASLTKLMTAYVVFAALYQKRVTLTQAVPVSTRAWRAQGSRMFIEPKKPVTVDELMRGMIVQSGNDASIALAEAVSG
SEEAFAQAMNKEAARMGMKNTRFANSTGLPDPDHYTTAYDLALLATAIIRDFPEYYPLYSLKEYTYNKITQANRNRLLWL
DPNVDGMKTGHTDAAGYCLITSARRGQRRLVAVVMGTASESARAMESQRLLNYGFQFYDTVRLYPGEQEVVAIPLWKGNQ
DKLRTGFGNDVYFSLPRHQTDKLKARMEYKQPLLAPVAAGQKVGTVKFMLEGKQVVEHPLVALETVSAANIFGRAWDSMR
LLFN

Sequences:

>Translated_404_residues
MTDSEARRITSSIWLGYNNAFLQIAMRRLLPISLCLLALPLAAQQPQFHAPPQTLSVAAKSYILADLQSGQVLVSKNAHE
RVDPASLTKLMTAYVVFAALYQKRVTLTQAVPVSTRAWRAQGSRMFIEPKKPVTVDELMRGMIVQSGNDASIALAEAVSG
SEEAFAQAMNKEAARMGMKNTRFANSTGLPDPDHYTTAYDLALLATAIIRDFPEYYPLYSLKEYTYNKITQANRNRLLWL
DPNVDGMKTGHTDAAGYCLITSARRGQRRLVAVVMGTASESARAMESQRLLNYGFQFYDTVRLYPGEQEVVAIPLWKGNQ
DKLRTGFGNDVYFSLPRHQTDKLKARMEYKQPLLAPVAAGQKVGTVKFMLEGKQVVEHPLVALETVSAANIFGRAWDSMR
LLFN
>Mature_403_residues
TDSEARRITSSIWLGYNNAFLQIAMRRLLPISLCLLALPLAAQQPQFHAPPQTLSVAAKSYILADLQSGQVLVSKNAHER
VDPASLTKLMTAYVVFAALYQKRVTLTQAVPVSTRAWRAQGSRMFIEPKKPVTVDELMRGMIVQSGNDASIALAEAVSGS
EEAFAQAMNKEAARMGMKNTRFANSTGLPDPDHYTTAYDLALLATAIIRDFPEYYPLYSLKEYTYNKITQANRNRLLWLD
PNVDGMKTGHTDAAGYCLITSARRGQRRLVAVVMGTASESARAMESQRLLNYGFQFYDTVRLYPGEQEVVAIPLWKGNQD
KLRTGFGNDVYFSLPRHQTDKLKARMEYKQPLLAPVAAGQKVGTVKFMLEGKQVVEHPLVALETVSAANIFGRAWDSMRL
LFN

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=371, Percent_Identity=44.2048517520216, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI1786851, Length=400, Percent_Identity=41.25, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI87082022, Length=382, Percent_Identity=40.0523560209424, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI87082054, Length=267, Percent_Identity=30.7116104868914, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 44995; Mature: 44864

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSEARRITSSIWLGYNNAFLQIAMRRLLPISLCLLALPLAAQQPQFHAPPQTLSVAAK
CCCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SYILADLQSGQVLVSKNAHERVDPASLTKLMTAYVVFAALYQKRVTLTQAVPVSTRAWRA
HHHEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
QGSRMFIEPKKPVTVDELMRGMIVQSGNDASIALAEAVSGSEEAFAQAMNKEAARMGMKN
CCCEEEECCCCCCCHHHHHHHHEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHHHCCCCC
TRFANSTGLPDPDHYTTAYDLALLATAIIRDFPEYYPLYSLKEYTYNKITQANRNRLLWL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHCCCCEEEEE
DPNVDGMKTGHTDAAGYCLITSARRGQRRLVAVVMGTASESARAMESQRLLNYGFQFYDT
CCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCHHEEEE
VRLYPGEQEVVAIPLWKGNQDKLRTGFGNDVYFSLPRHQTDKLKARMEYKQPLLAPVAAG
EEECCCCCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCC
QKVGTVKFMLEGKQVVEHPLVALETVSAANIFGRAWDSMRLLFN
CCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDSEARRITSSIWLGYNNAFLQIAMRRLLPISLCLLALPLAAQQPQFHAPPQTLSVAAK
CCHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
SYILADLQSGQVLVSKNAHERVDPASLTKLMTAYVVFAALYQKRVTLTQAVPVSTRAWRA
HHHEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
QGSRMFIEPKKPVTVDELMRGMIVQSGNDASIALAEAVSGSEEAFAQAMNKEAARMGMKN
CCCEEEECCCCCCCHHHHHHHHEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHHHCCCCC
TRFANSTGLPDPDHYTTAYDLALLATAIIRDFPEYYPLYSLKEYTYNKITQANRNRLLWL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHCCCCEEEEE
DPNVDGMKTGHTDAAGYCLITSARRGQRRLVAVVMGTASESARAMESQRLLNYGFQFYDT
CCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCHHEEEE
VRLYPGEQEVVAIPLWKGNQDKLRTGFGNDVYFSLPRHQTDKLKARMEYKQPLLAPVAAG
EEECCCCCCEEEEEECCCCHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCC
QKVGTVKFMLEGKQVVEHPLVALETVSAANIFGRAWDSMRLLFN
CCCCEEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]