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The map label for this gene is adk [H]

Identifier: 82701874

GI number: 82701874

Start: 862582

End: 863220

Strand: Reverse

Name: adk [H]

Synonym: Nmul_A0741

Alternate gene names: 82701874

Gene position: 863220-862582 (Counterclockwise)

Preceding gene: 82701875

Following gene: 82701873

Centisome position: 27.11

GC content: 53.83

Gene sequence:

>639_bases
TTGGGTGGTCCCGGCGCGGGAAAGGGAACTCAAGCCAACTTCATCAAGGAGCATTTCGGCATTCCGCAGATATCGACAGG
AGACATGCTGCGCGCAGCTGTCAAGGAAGGCACCGAACTGGGCCTCATGGCCAAAAAGATCATGGACGAGGGCGGTCTTG
TTCCGGATGACGTTATCATCGGTCTGGTGAAAGCCCGCATTGCACAGCCGGATTGCAGCAAGGGTTTTCTGTTTGATGGC
TTTCCCCGTACCATCCCGCAGGCGGATGCAATGAAGGCTGCCAAGGTGCCTCTCCAGTTCGTCATTGAAATTGATGTATC
CGACGAAGAGATTGTCAGGCGCCTCTCCGGGCGGCGGGTACATCCTGCCTCGGGGCGTATTTACCATTTGATATTCAGTC
CGCCCCGGGTCGATGAGAAGGATGATGTAACCGGCGAGCCACTGATACAGCGTGATGATGATAAAGAGGAAACGATCCGG
AAACGGCTCGAAATCTATCACGCCCAGACCGAACCATTGGTAGAATACTACGCCAGATGGTCAGCTAGTGGCGAAAAAGA
TGCTCCCAAGTATGTGAAAATCACGGGGGCCGGATCAGTGGAAACAATCCGCGACGCTATTTTTGCATCGTTGAGATAG

Upstream 100 bases:

>100_bases
ATGGCCTGCGCTATAATCTCTTGTTTGACAACAAAATGGATCTCGCCTCCCGCCTCGCCAGCGGGCTTTATAAAAAGGAG
GAATAATCATAATTGTCTTA

Downstream 100 bases:

>100_bases
CTTCAGTCAAAACTCCTGGTGGAACTCAAGCCTGGTATCACCGCCGTTTTAATTCGCTAAGAGAGCAATACGCAGCGGCG
ATAGTCCTCGTTGCCGTATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MGGPGAGKGTQANFIKEHFGIPQISTGDMLRAAVKEGTELGLMAKKIMDEGGLVPDDVIIGLVKARIAQPDCSKGFLFDG
FPRTIPQADAMKAAKVPLQFVIEIDVSDEEIVRRLSGRRVHPASGRIYHLIFSPPRVDEKDDVTGEPLIQRDDDKEETIR
KRLEIYHAQTEPLVEYYARWSASGEKDAPKYVKITGAGSVETIRDAIFASLR

Sequences:

>Translated_212_residues
MGGPGAGKGTQANFIKEHFGIPQISTGDMLRAAVKEGTELGLMAKKIMDEGGLVPDDVIIGLVKARIAQPDCSKGFLFDG
FPRTIPQADAMKAAKVPLQFVIEIDVSDEEIVRRLSGRRVHPASGRIYHLIFSPPRVDEKDDVTGEPLIQRDDDKEETIR
KRLEIYHAQTEPLVEYYARWSASGEKDAPKYVKITGAGSVETIRDAIFASLR
>Mature_211_residues
GGPGAGKGTQANFIKEHFGIPQISTGDMLRAAVKEGTELGLMAKKIMDEGGLVPDDVIIGLVKARIAQPDCSKGFLFDGF
PRTIPQADAMKAAKVPLQFVIEIDVSDEEIVRRLSGRRVHPASGRIYHLIFSPPRVDEKDDVTGEPLIQRDDDKEETIRK
RLEIYHAQTEPLVEYYARWSASGEKDAPKYVKITGAGSVETIRDAIFASLR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=217, Percent_Identity=45.1612903225806, Blast_Score=194, Evalue=4e-50,
Organism=Homo sapiens, GI7524346, Length=192, Percent_Identity=48.4375, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI19923437, Length=179, Percent_Identity=47.4860335195531, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI310110345, Length=178, Percent_Identity=43.8202247191011, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832003, Length=178, Percent_Identity=43.8202247191011, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI8051579, Length=178, Percent_Identity=43.8202247191011, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832001, Length=178, Percent_Identity=43.8202247191011, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4502011, Length=212, Percent_Identity=31.1320754716981, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI22749187, Length=189, Percent_Identity=26.4550264550265, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI28144897, Length=178, Percent_Identity=31.4606741573034, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI28144899, Length=178, Percent_Identity=31.4606741573034, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI7706497, Length=200, Percent_Identity=29, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI21450759, Length=136, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1786680, Length=204, Percent_Identity=61.2745098039216, Blast_Score=253, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17552384, Length=194, Percent_Identity=47.9381443298969, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=183, Percent_Identity=35.5191256830601, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=34.2723004694836, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320432, Length=200, Percent_Identity=51, Blast_Score=212, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=41.9354838709677, Blast_Score=144, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=220, Percent_Identity=29.5454545454545, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI22026816, Length=216, Percent_Identity=46.2962962962963, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17737899, Length=179, Percent_Identity=43.5754189944134, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645822, Length=179, Percent_Identity=43.5754189944134, Blast_Score=153, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24663208, Length=178, Percent_Identity=32.5842696629214, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647141, Length=178, Percent_Identity=32.5842696629214, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=181, Percent_Identity=29.2817679558011, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356893, Length=181, Percent_Identity=29.2817679558011, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23348; Mature: 23217

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGPGAGKGTQANFIKEHFGIPQISTGDMLRAAVKEGTELGLMAKKIMDEGGLVPDDVII
CCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
GLVKARIAQPDCSKGFLFDGFPRTIPQADAMKAAKVPLQFVIEIDVSDEEIVRRLSGRRV
HHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHCCCEEEEEEEECCHHHHHHHHHCCEE
HPASGRIYHLIFSPPRVDEKDDVTGEPLIQRDDDKEETIRKRLEIYHAQTEPLVEYYARW
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
SASGEKDAPKYVKITGAGSVETIRDAIFASLR
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
GGPGAGKGTQANFIKEHFGIPQISTGDMLRAAVKEGTELGLMAKKIMDEGGLVPDDVII
CCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHH
GLVKARIAQPDCSKGFLFDGFPRTIPQADAMKAAKVPLQFVIEIDVSDEEIVRRLSGRRV
HHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHCCCEEEEEEEECCHHHHHHHHHCCEE
HPASGRIYHLIFSPPRVDEKDDVTGEPLIQRDDDKEETIRKRLEIYHAQTEPLVEYYARW
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
SASGEKDAPKYVKITGAGSVETIRDAIFASLR
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA