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The map label for this gene is csgA [H]

Identifier: 82701868

GI number: 82701868

Start: 854945

End: 855646

Strand: Reverse

Name: csgA [H]

Synonym: Nmul_A0735

Alternate gene names: 82701868

Gene position: 855646-854945 (Counterclockwise)

Preceding gene: 82701870

Following gene: 82701865

Centisome position: 26.87

GC content: 53.99

Gene sequence:

>702_bases
ATGAAAACTGTACTGATCACCGGCGCAAACCGTGGGATTGGACTTGAATTCGTCCGTCAATACGCAGCGGAAGGCTGGCG
TGTTCTTGCCTGCGCGCGCCATCCCGAGAAAGCAGGAGAACTTCAAACGCTGGCAAACCAGCAGCCGGAGCAGACAAAGA
TACATACGCTTGATGTTGCCGACCACCGGCGAATCGACGAACTGGGACAGTCTCTTTCCGGCGAATCCATCGATCTGCTT
CTCAATAATGCCGGCATCTATGCGGAGGCGCATCGTTCGGGAATATTCAGGAGCGAGGATTACGAAGCCTGGATGCGCAC
GTTTCTGGTCAATACCATGGCGACACTCAAGATGGCCCAGACATTTACCTCACAGATCGCCCGGAGCGATCAGAAAAAGA
TTGTGACCATCAGCAGTAAAATGGGCAGTATCGAGGACAATGATGGCGGGGGAAGCTATATGTACCGATCCAGCAAGGCG
GCGGTGAACATGGTGGTCAAATCGCTTTCGATTGATCTGAAACAGGCGCGAGTAATTGCGGTGGTACTGCATCCGGGATG
GGTGAAAACAGACATGGGAGGACCGAATGCCTTGATCTCCCCTGTTCAAAGCGTCTCCGGCATGCGGCAGGTAATCGATC
GCCTCACTCTTAAGGATTCCGGCAGGTTCATTGAGTACGACGGCAAGCCGGTGCCGTGGTAG

Upstream 100 bases:

>100_bases
GCAGTGAAATTCATCCTCCGATACTTCTTTATAGTACCTGCCACACCGCGAGCTGGTTTCTCCCGAATACCTGATCCGTA
TATTCCATGAGGAGAAGATT

Downstream 100 bases:

>100_bases
GGCATTCCTGCCGGATTGATTACTCGTCTGGCCGCCATAAGCTCCCGCGCTCCGGTTATTCGACGATTACAGCCGTGCCG
CTTGCCGAAACCATGAGCAT

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKTVLITGANRGIGLEFVRQYAAEGWRVLACARHPEKAGELQTLANQQPEQTKIHTLDVADHRRIDELGQSLSGESIDLL
LNNAGIYAEAHRSGIFRSEDYEAWMRTFLVNTMATLKMAQTFTSQIARSDQKKIVTISSKMGSIEDNDGGGSYMYRSSKA
AVNMVVKSLSIDLKQARVIAVVLHPGWVKTDMGGPNALISPVQSVSGMRQVIDRLTLKDSGRFIEYDGKPVPW

Sequences:

>Translated_233_residues
MKTVLITGANRGIGLEFVRQYAAEGWRVLACARHPEKAGELQTLANQQPEQTKIHTLDVADHRRIDELGQSLSGESIDLL
LNNAGIYAEAHRSGIFRSEDYEAWMRTFLVNTMATLKMAQTFTSQIARSDQKKIVTISSKMGSIEDNDGGGSYMYRSSKA
AVNMVVKSLSIDLKQARVIAVVLHPGWVKTDMGGPNALISPVQSVSGMRQVIDRLTLKDSGRFIEYDGKPVPW
>Mature_233_residues
MKTVLITGANRGIGLEFVRQYAAEGWRVLACARHPEKAGELQTLANQQPEQTKIHTLDVADHRRIDELGQSLSGESIDLL
LNNAGIYAEAHRSGIFRSEDYEAWMRTFLVNTMATLKMAQTFTSQIARSDQKKIVTISSKMGSIEDNDGGGSYMYRSSKA
AVNMVVKSLSIDLKQARVIAVVLHPGWVKTDMGGPNALISPVQSVSGMRQVIDRLTLKDSGRFIEYDGKPVPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI10190746, Length=222, Percent_Identity=31.5315315315315, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7657478, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787820, Length=190, Percent_Identity=30, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=29.8969072164948, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532177, Length=253, Percent_Identity=32.4110671936759, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17558994, Length=256, Percent_Identity=31.25, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17558992, Length=260, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193207563, Length=250, Percent_Identity=29.6, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17558990, Length=250, Percent_Identity=29.6, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17559964, Length=251, Percent_Identity=32.2709163346614, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI72001658, Length=243, Percent_Identity=32.5102880658436, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17559962, Length=219, Percent_Identity=33.7899543378995, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17542178, Length=245, Percent_Identity=32.6530612244898, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17541382, Length=256, Percent_Identity=30.46875, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558996, Length=257, Percent_Identity=27.6264591439689, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17558006, Length=225, Percent_Identity=25.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322779, Length=248, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=31.3131313131313, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=34.8, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24643142, Length=195, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25753; Mature: 25753

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLITGANRGIGLEFVRQYAAEGWRVLACARHPEKAGELQTLANQQPEQTKIHTLDVA
CCEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECH
DHRRIDELGQSLSGESIDLLLNNAGIYAEAHRSGIFRSEDYEAWMRTFLVNTMATLKMAQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TFTSQIARSDQKKIVTISSKMGSIEDNDGGGSYMYRSSKAAVNMVVKSLSIDLKQARVIA
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEE
VVLHPGWVKTDMGGPNALISPVQSVSGMRQVIDRLTLKDSGRFIEYDGKPVPW
EEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure
MKTVLITGANRGIGLEFVRQYAAEGWRVLACARHPEKAGELQTLANQQPEQTKIHTLDVA
CCEEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEECH
DHRRIDELGQSLSGESIDLLLNNAGIYAEAHRSGIFRSEDYEAWMRTFLVNTMATLKMAQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TFTSQIARSDQKKIVTISSKMGSIEDNDGGGSYMYRSSKAAVNMVVKSLSIDLKQARVIA
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEE
VVLHPGWVKTDMGGPNALISPVQSVSGMRQVIDRLTLKDSGRFIEYDGKPVPW
EEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]