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The map label for this gene is thrB [H]

Identifier: 78778980

GI number: 78778980

Start: 558968

End: 559915

Strand: Reverse

Name: thrB [H]

Synonym: PMT9312_0595

Alternate gene names: 78778980

Gene position: 559915-558968 (Counterclockwise)

Preceding gene: 78778981

Following gene: 78778979

Centisome position: 32.76

GC content: 41.77

Gene sequence:

>948_bases
ATGTCTATTCCTGAAGTAGGAAAAAAAATAAGAGTAACAGTACCTTCCACAACTGCTAATTTGGGGCCTGGATTCGACTG
CCTTGGTGCAGCATTAGATTTACATAATGAATTTATTTTTACAAGAATTGAAGGTGGTGGAGATAGATTTGATCTAATAA
TGGAAAGTACAGATGGGAATCATTTAAGAGGGGGACCTGAAAACTTAGTTTTTAGAGCGGCTCAGAAAGTATGGGAGAGT
GCAAATATGGAGCCTTTTGCGCTTGAAGCAAGAGTAAAGTTGGCTGTACCTCCGGCACGCGGCCTTGGAAGTAGTGCTAC
AGCAATAGTTGCTGGACTAATCGGAGCAAATGCAATAATGAACTCTCCACTGCCCAAAGAAAAACTTCTAGAACTTGCTA
TTGATATTGAAGGCCATCCTGATAATGTAGTACCCTCTCTTTTGGGGGGGCTTTGCTTAACGGCCCGGTCTTCTTCTCAA
AGATGGAGAATCATAAGATGTGATTGGCACGACTCTATCAAAGCTGTTGTAGCAATACCTGCGATTCGTTTAAGCACAAG
TGAAGCAAGGAAAGTAATGCCTAAGAATGTACCAATATCTGATGCAGTTACAAATATGGGGGCACTTACTTTATTGCTAA
ATGGCTTAAAAGCAGGAAACGATGAATTAATAAAAGAGGGAATGTTTGATAAGCTACATGAACCATACCGATGGAAGCTT
ATTAAAGGTGGGCTGGAAGTCAAAGATGCCGCACTACAAGCAGGTGCTTTAGGATGCGCAATTAGTGGGGCGGGACCAAG
CATCTTAGCTTTGTGTAAAAAAGAAAATGGCAAGGAGGTTAGTCAAGCCATGGTAAAAGCATGGGAGAAGTCAGGTGTAG
CAAGTAGAGCACCATTTTTAAACCTTCAAACAACAGGCAGCCAATTCAGCACTATCTCTAGTAGGTAG

Upstream 100 bases:

>100_bases
TCTTAAAACAATACCTCTGAAAGTGATTTTAGATGAAGAGTTTGGGCTTTTTAGTGCAGCCTGCAGAGCAAAAATGCTTT
TAAAAACTGAGTAACAAGAA

Downstream 100 bases:

>100_bases
TTTTACTTAGGCATTTTTAATGTTATAGTCTCAAGCTAGTGCAACTTCAACTAGAATAAAAAAATTATTCATTACAAAAT
GAATTTAGAATCTTTCCCTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLHNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWES
ANMEPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQ
RWRIIRCDWHDSIKAVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNDELIKEGMFDKLHEPYRWKL
IKGGLEVKDAALQAGALGCAISGAGPSILALCKKENGKEVSQAMVKAWEKSGVASRAPFLNLQTTGSQFSTISSR

Sequences:

>Translated_315_residues
MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLHNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWES
ANMEPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQ
RWRIIRCDWHDSIKAVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNDELIKEGMFDKLHEPYRWKL
IKGGLEVKDAALQAGALGCAISGAGPSILALCKKENGKEVSQAMVKAWEKSGVASRAPFLNLQTTGSQFSTISSR
>Mature_314_residues
SIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLHNEFIFTRIEGGGDRFDLIMESTDGNHLRGGPENLVFRAAQKVWESA
NMEPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIMNSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQR
WRIIRCDWHDSIKAVVAIPAIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNDELIKEGMFDKLHEPYRWKLI
KGGLEVKDAALQAGALGCAISGAGPSILALCKKENGKEVSQAMVKAWEKSGVASRAPFLNLQTTGSQFSTISSR

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=292, Percent_Identity=29.7945205479452, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321814, Length=338, Percent_Identity=31.3609467455621, Blast_Score=152, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33541; Mature: 33410

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLHNEFIFTRIEGGGDRFDLIMESTDGN
CCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCC
HLRGGPENLVFRAAQKVWESANMEPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIM
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCDWHDSIKAVVAIP
CCCCCHHHHHEEEEECCCCCCCHHHHHHHHHEEEECCCCCCEEEEEECCCCCCEEEEEEC
AIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNDELIKEGMFDKLHEPYRWKL
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
IKGGLEVKDAALQAGALGCAISGAGPSILALCKKENGKEVSQAMVKAWEKSGVASRAPFL
EECCCCHHHHHHHCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEE
NLQTTGSQFSTISSR
EEEECCCCCHHCCCC
>Mature Secondary Structure 
SIPEVGKKIRVTVPSTTANLGPGFDCLGAALDLHNEFIFTRIEGGGDRFDLIMESTDGN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCC
HLRGGPENLVFRAAQKVWESANMEPFALEARVKLAVPPARGLGSSATAIVAGLIGANAIM
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
NSPLPKEKLLELAIDIEGHPDNVVPSLLGGLCLTARSSSQRWRIIRCDWHDSIKAVVAIP
CCCCCHHHHHEEEEECCCCCCCHHHHHHHHHEEEECCCCCCEEEEEECCCCCCEEEEEEC
AIRLSTSEARKVMPKNVPISDAVTNMGALTLLLNGLKAGNDELIKEGMFDKLHEPYRWKL
EEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEE
IKGGLEVKDAALQAGALGCAISGAGPSILALCKKENGKEVSQAMVKAWEKSGVASRAPFL
EECCCCHHHHHHHCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEE
NLQTTGSQFSTISSR
EEEECCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA