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The map label for this gene is hemC

Identifier: 78778881

GI number: 78778881

Start: 463780

End: 464730

Strand: Reverse

Name: hemC

Synonym: PMT9312_0496

Alternate gene names: 78778881

Gene position: 464730-463780 (Counterclockwise)

Preceding gene: 78778882

Following gene: 78778878

Centisome position: 27.19

GC content: 35.44

Gene sequence:

>951_bases
ATGACTAATTTTAAACTTAAAATAGCTAGTAGAAGAAGTAAACTAGCCATGGTACAAACTTTATGGGTTAAAGATCAACT
AGAAAAAAATATTCCCAATTTAGAGGTATCCATAGAAGCCATGGCAACTCAAGGTGACAAAATTCTTGATGTAGCCCTAG
CAAAAATAGGTGACAAGGGCTTATTCACAAAAGAACTTGAAGCACAAATGCTTGTAGGCCAAGCAGATATAGCAGTACAT
TCTCTAAAAGATTTACCAACAAATTTGCCTAGTGGCCTTAAATTAGGATGCATCACAAAAAGAGAAGACCCCGCAGATGC
TTTAGTAGTAAGCAAAAAAAATGATTGCTATAAATTAGAAACTTTACCTGCAGGTTCAATTGTGGGGACAAGCTCTCTTA
GAAGACTCGCACAATTAAGAAATAAGTACCCACATCTTAACTTCAAGGATATCAGAGGAAATGTTATTACAAGAATAGAA
AAATTAGATGCAGGAGAATTTGATTGCATAATTCTTGCTGCCGCTGGTTTAAAAAGATTAGGCTTTGAATCAAGAATTCA
TCAGATCATACCAAATGAAATTTCCCTTCATGCCGTTGGACAAGGAGCACTAGGAATTGAATGTAAATCTGATGATAAAA
AAGTTTTAGAAATTATAAGTGTCTTAGAAGATAAACCCACTAGTCAAAGATGTCTAGCAGAAAGGGCTTTTTTAAGAGAA
CTTGAAGGAGGATGCCAAGTTCCAATAGGCGTAAATAGTAGTATTCAAAATGAACAACTTTACCTTACTGGAATGGTAGC
CTCTCTTGATGGAGAAAGGCTGATTAAAGATCAATATATTGGCAATATTGATGATCCTGAACAAGTAGGCAAAGAACTAG
CTAAGAAACTAAAGCTCCAAGGGGCTGACAAAATACTGAGCGAAATCTTTGAACAATTTAGGGAGAACTGA

Upstream 100 bases:

>100_bases
ATAATAATAGTTAAATATAATTTTCAGCTTTAAAAAGTTGCAAAATAATAGCTTAAAATAGATACGACTTAATTTTAATC
CAAACTCAAAATAATATTTG

Downstream 100 bases:

>100_bases
AATTAATTAATTAATTTAGGATCAATTTCCTTTTTATATCTATCTTCGCAATCTTTAATTACTTTAACAGCTTCTTTTAT
CCCGAAAAAACCATTTACAG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGQADIAVH
SLKDLPTNLPSGLKLGCITKREDPADALVVSKKNDCYKLETLPAGSIVGTSSLRRLAQLRNKYPHLNFKDIRGNVITRIE
KLDAGEFDCIILAAAGLKRLGFESRIHQIIPNEISLHAVGQGALGIECKSDDKKVLEIISVLEDKPTSQRCLAERAFLRE
LEGGCQVPIGVNSSIQNEQLYLTGMVASLDGERLIKDQYIGNIDDPEQVGKELAKKLKLQGADKILSEIFEQFREN

Sequences:

>Translated_316_residues
MTNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGQADIAVH
SLKDLPTNLPSGLKLGCITKREDPADALVVSKKNDCYKLETLPAGSIVGTSSLRRLAQLRNKYPHLNFKDIRGNVITRIE
KLDAGEFDCIILAAAGLKRLGFESRIHQIIPNEISLHAVGQGALGIECKSDDKKVLEIISVLEDKPTSQRCLAERAFLRE
LEGGCQVPIGVNSSIQNEQLYLTGMVASLDGERLIKDQYIGNIDDPEQVGKELAKKLKLQGADKILSEIFEQFREN
>Mature_315_residues
TNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGQADIAVHS
LKDLPTNLPSGLKLGCITKREDPADALVVSKKNDCYKLETLPAGSIVGTSSLRRLAQLRNKYPHLNFKDIRGNVITRIEK
LDAGEFDCIILAAAGLKRLGFESRIHQIIPNEISLHAVGQGALGIECKSDDKKVLEIISVLEDKPTSQRCLAERAFLREL
EGGCQVPIGVNSSIQNEQLYLTGMVASLDGERLIKDQYIGNIDDPEQVGKELAKKLKLQGADKILSEIFEQFREN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=284, Percent_Identity=52.4647887323944, Blast_Score=294, Evalue=8e-80,
Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=52.4647887323944, Blast_Score=294, Evalue=8e-80,
Organism=Escherichia coli, GI48994974, Length=310, Percent_Identity=50.9677419354839, Blast_Score=296, Evalue=9e-82,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=44.9367088607595, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI20130425, Length=318, Percent_Identity=43.3962264150943, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34901; Mature: 34770

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKG
CCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGQADIAVHSLKDLPTNLPSGLKLGCITKREDPADALVVSKKNDCYKLE
CCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEE
TLPAGSIVGTSSLRRLAQLRNKYPHLNFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRL
ECCCCCEECHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHC
GFESRIHQIIPNEISLHAVGQGALGIECKSDDKKVLEIISVLEDKPTSQRCLAERAFLRE
CHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LEGGCQVPIGVNSSIQNEQLYLTGMVASLDGERLIKDQYIGNIDDPEQVGKELAKKLKLQ
HCCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GADKILSEIFEQFREN
CHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNFKLKIASRRSKLAMVQTLWVKDQLEKNIPNLEVSIEAMATQGDKILDVALAKIGDKG
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVGQADIAVHSLKDLPTNLPSGLKLGCITKREDPADALVVSKKNDCYKLE
CCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCEEEE
TLPAGSIVGTSSLRRLAQLRNKYPHLNFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRL
ECCCCCEECHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHC
GFESRIHQIIPNEISLHAVGQGALGIECKSDDKKVLEIISVLEDKPTSQRCLAERAFLRE
CHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LEGGCQVPIGVNSSIQNEQLYLTGMVASLDGERLIKDQYIGNIDDPEQVGKELAKKLKLQ
HCCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GADKILSEIFEQFREN
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA