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The map label for this gene is ageIM [H]

Identifier: 78778763

GI number: 78778763

Start: 358468

End: 360528

Strand: Reverse

Name: ageIM [H]

Synonym: PMT9312_0378

Alternate gene names: 78778763

Gene position: 360528-358468 (Counterclockwise)

Preceding gene: 78778764

Following gene: 78778756

Centisome position: 21.09

GC content: 34.74

Gene sequence:

>2061_bases
ATGATTCATAAAAATGCAGTAGGGAAAACTGATCCTCACAGATTAAGTCCTGTAAGAGGGCCTTCATCAGAACTTGAGGC
ACATGTAGATTCATGCAGTTTTGATGAACTTCCTGAATATGCAGCAAAGGTTCGATCTATAAAAAAAGAACCTTATTTTG
CTGTTGACCTTTTTTCAGGTGCCGGCGGTTTAAGCCTTGGACTGCATCGTGCAAATTTTGATGTAATACTGGCCTGCGAT
ATCAGAAACGATTCAATAATGACTCACAGACATCACTTTGGTGGATGCTCATATGAATGCGATTTAAGCAAAAGAAAAGT
TATTAATGAAATTTCAGAACAACTTAATAAGTGTGGAGAAATATCACTTATTGCAGGTGGACCCCCATGTCAGCCTTTCT
CCCGAAATATCAAATGGAGAAAACATAACGAAGAAGTTTCTGCTCAACATCAGGAACTTAATGAAGATAGAAGAGAATTA
TGGGAATCATTTATTTCGATAGTGGAGCAGGTTAAACCAAAAGCTTTTCTAATGGAGAATGTTACTGATATTGCGCAGAC
AGGTGAGCAGGAAATATATAGATCAATCATTAATAGAGCTGAGAAAGCTGGCTATCGCATAAATCCTAAATTAATTTATG
CATGGCAATATGGAGTGCCTCAACTAAGGCCTAGATTATTTATTTCCGGAACAAAAATAAATGAATGTGCTCCTATGAAA
TGGCCAAAGCCTAAATATGATTCTGTCGAAGAGGCAGTCACATTAGACGAGGCGATTTCAGATCTCCCTCCACTTAAAGG
AGGATGGAATGAAAAGTGGGATGAAAAATATAGCTATGAAGGACCAAAAAACGATTATCAGAAATTAATGAGGGATTGGT
TGGATATTGATGACGAGATGATTCATGATCACCTTATAAGAAAAGTTAGAGAAGATGATCTTGAGACATTTAAATTAATG
CGATCAACCGGGGTCAAATATTCCCAATTATCAGAAGAGCAAAGAAGATATTCAGTTACGAGCAAAGCTTTCAGAGAAGG
TAAGAAAGTAAAGCAAAATCAGAAAATGAGTTTTGGTGATAAATACAATATCCTCAAACCTAATGAACCATGTCTGACAA
TAACTGCCCATATGTCAAAAGATGGTTATTGGTATATTCACCCTCACCAGAATAGAACCCTATCAGTCAGAGAAGCGGCA
AGAGTTCAGTCATTTCCTGATGGTTTCAATTTTTATGGAGGGCCTTCAAATAGATTCCACCAAATTGGAGAGGCTGTTGC
ACCGATTGTTGCTTTTGAACTCGGCAAATCTTTAATGAAATCAATTAAAAATGACAAAGAATTTACCCAACCTGATGTAG
TGCCCAAACTTAGAGAAAATCTTATTAACTGGTATGAATCAAATAAAAAAGAAGTTGAACTTATATGGACAAAGAAAAGG
GAAGGTAGAAAAATAATTCCAAGCAATATAAGGGCATGGAACGCATTTCTTGGAAATTTACTGCCAGAGACTTTTAAAAA
AAACAATAAAGAAAAAAATAAACCTGCGATCTTAGGAGATAAAGATCTCGAAAAAAGGAAGAAAGATACCTACCAAAGAT
TAAAAAACTTTTGGCCTACTCCTGAGATTTTTCTTCAAGATAAAGCTAGAAAAATGAAAATAAAAAGTTTTAGTCTTGAA
AAATATATCCCTTCACTAGAACTGATTGCAGAAGAACTTAAAAAAGATGAAATCGACTGGAGTGAAATCACAAGAAAAGA
ATATGATTTGTTCTCAAGGAATTCGGTGAGAGGAGCACTTGCTACTGTTGGATTAACCACCGAGATAAAACAATCCATAG
TAATTAGCAGAATTATTTCTCAGATCATGAATATTGATTATGAAATTTTGAAATTCAGCAATATGAATAGAGATATACAT
ATAGGTCATTTACTTGAAATGGATATCGAGGGGACAGGCTATTGTTCACTTCTAGCATTATCTAAAAATGAAAAAAAAGA
GACCATAATTAATTCTTTTTTTAAGAACATTCAGTTTAAAGAAGTTCATAAAGCTGCTTAA

Upstream 100 bases:

>100_bases
CAATAAGAAAATTAAATTCCATTGGAGGTTCAATATGTCTTGATCTTTTAAGTGAAGAACAACTCCAGCAGTTAATTGAT
ACTCAGAGTGAAGAGGTCGC

Downstream 100 bases:

>100_bases
ATAAATCCCTTTAGATTATTAATCTATTTTGATAACTTTTTTAAGTAATGACTTAGTAGATGAAACAAGTCCTCTATTTG
ACTGTTTTATTTCATTGATA

Product: DNA-cytosine methyltransferase

Products: NA

Alternate protein names: M.AgeI; Cytosine-specific methyltransferase AgeI [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MIHKNAVGKTDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSGAGGLSLGLHRANFDVILACD
IRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGEISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRREL
WESFISIVEQVKPKAFLMENVTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
WPKPKYDSVEEAVTLDEAISDLPPLKGGWNEKWDEKYSYEGPKNDYQKLMRDWLDIDDEMIHDHLIRKVREDDLETFKLM
RSTGVKYSQLSEEQRRYSVTSKAFREGKKVKQNQKMSFGDKYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAA
RVQSFPDGFNFYGGPSNRFHQIGEAVAPIVAFELGKSLMKSIKNDKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
EGRKIIPSNIRAWNAFLGNLLPETFKKNNKEKNKPAILGDKDLEKRKKDTYQRLKNFWPTPEIFLQDKARKMKIKSFSLE
KYIPSLELIAEELKKDEIDWSEITRKEYDLFSRNSVRGALATVGLTTEIKQSIVISRIISQIMNIDYEILKFSNMNRDIH
IGHLLEMDIEGTGYCSLLALSKNEKKETIINSFFKNIQFKEVHKAA

Sequences:

>Translated_686_residues
MIHKNAVGKTDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSGAGGLSLGLHRANFDVILACD
IRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGEISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRREL
WESFISIVEQVKPKAFLMENVTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
WPKPKYDSVEEAVTLDEAISDLPPLKGGWNEKWDEKYSYEGPKNDYQKLMRDWLDIDDEMIHDHLIRKVREDDLETFKLM
RSTGVKYSQLSEEQRRYSVTSKAFREGKKVKQNQKMSFGDKYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAA
RVQSFPDGFNFYGGPSNRFHQIGEAVAPIVAFELGKSLMKSIKNDKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
EGRKIIPSNIRAWNAFLGNLLPETFKKNNKEKNKPAILGDKDLEKRKKDTYQRLKNFWPTPEIFLQDKARKMKIKSFSLE
KYIPSLELIAEELKKDEIDWSEITRKEYDLFSRNSVRGALATVGLTTEIKQSIVISRIISQIMNIDYEILKFSNMNRDIH
IGHLLEMDIEGTGYCSLLALSKNEKKETIINSFFKNIQFKEVHKAA
>Mature_686_residues
MIHKNAVGKTDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSGAGGLSLGLHRANFDVILACD
IRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGEISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRREL
WESFISIVEQVKPKAFLMENVTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
WPKPKYDSVEEAVTLDEAISDLPPLKGGWNEKWDEKYSYEGPKNDYQKLMRDWLDIDDEMIHDHLIRKVREDDLETFKLM
RSTGVKYSQLSEEQRRYSVTSKAFREGKKVKQNQKMSFGDKYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAA
RVQSFPDGFNFYGGPSNRFHQIGEAVAPIVAFELGKSLMKSIKNDKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
EGRKIIPSNIRAWNAFLGNLLPETFKKNNKEKNKPAILGDKDLEKRKKDTYQRLKNFWPTPEIFLQDKARKMKIKSFSLE
KYIPSLELIAEELKKDEIDWSEITRKEYDLFSRNSVRGALATVGLTTEIKQSIVISRIISQIMNIDYEILKFSNMNRDIH
IGHLLEMDIEGTGYCSLLALSKNEKKETIINSFFKNIQFKEVHKAA

Specific function: This methylase recognizes the double-stranded sequence ACCGGT, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the AgeI endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI195927037, Length=464, Percent_Identity=23.9224137931034, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI4503351, Length=464, Percent_Identity=23.9224137931034, Blast_Score=106, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 79535; Mature: 79535

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00094 C5_MTASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHKNAVGKTDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
AGGLSLGLHRANFDVILACDIRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGE
CCCCEEEEEECCCCEEEEEECCCCCEEEEHHHCCCCCEECCCHHHHHHHHHHHHHHCCCC
ISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRRELWESFISIVEQVKPKAFLMEN
EEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
HHHHHHCCHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
WPKPKYDSVEEAVTLDEAISDLPPLKGGWNEKWDEKYSYEGPKNDYQKLMRDWLDIDDEM
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHH
IHDHLIRKVREDDLETFKLMRSTGVKYSQLSEEQRRYSVTSKAFREGKKVKQNQKMSFGD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAARVQSFPDGFNFYGGPSNRFH
CCCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCHHHH
QIGEAVAPIVAFELGKSLMKSIKNDKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
EGRKIIPSNIRAWNAFLGNLLPETFKKNNKEKNKPAILGDKDLEKRKKDTYQRLKNFWPT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCC
PEIFLQDKARKMKIKSFSLEKYIPSLELIAEELKKDEIDWSEITRKEYDLFSRNSVRGAL
CHHHHHCHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHH
ATVGLTTEIKQSIVISRIISQIMNIDYEILKFSNMNRDIHIGHLLEMDIEGTGYCSLLAL
HHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCCCCCEEEEEE
SKNEKKETIINSFFKNIQFKEVHKAA
CCCCHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MIHKNAVGKTDPHRLSPVRGPSSELEAHVDSCSFDELPEYAAKVRSIKKEPYFAVDLFSG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
AGGLSLGLHRANFDVILACDIRNDSIMTHRHHFGGCSYECDLSKRKVINEISEQLNKCGE
CCCCEEEEEECCCCEEEEEECCCCCEEEEHHHCCCCCEECCCHHHHHHHHHHHHHHCCCC
ISLIAGGPPCQPFSRNIKWRKHNEEVSAQHQELNEDRRELWESFISIVEQVKPKAFLMEN
EEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VTDIAQTGEQEIYRSIINRAEKAGYRINPKLIYAWQYGVPQLRPRLFISGTKINECAPMK
HHHHHHCCHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
WPKPKYDSVEEAVTLDEAISDLPPLKGGWNEKWDEKYSYEGPKNDYQKLMRDWLDIDDEM
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHH
IHDHLIRKVREDDLETFKLMRSTGVKYSQLSEEQRRYSVTSKAFREGKKVKQNQKMSFGD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KYNILKPNEPCLTITAHMSKDGYWYIHPHQNRTLSVREAARVQSFPDGFNFYGGPSNRFH
CCCCCCCCCCEEEEEEEECCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCCCHHHH
QIGEAVAPIVAFELGKSLMKSIKNDKEFTQPDVVPKLRENLINWYESNKKEVELIWTKKR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
EGRKIIPSNIRAWNAFLGNLLPETFKKNNKEKNKPAILGDKDLEKRKKDTYQRLKNFWPT
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCC
PEIFLQDKARKMKIKSFSLEKYIPSLELIAEELKKDEIDWSEITRKEYDLFSRNSVRGAL
CHHHHHCHHHHHHHHHCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHH
ATVGLTTEIKQSIVISRIISQIMNIDYEILKFSNMNRDIHIGHLLEMDIEGTGYCSLLAL
HHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEEEECCCCCCCEEEEEE
SKNEKKETIINSFFKNIQFKEVHKAA
CCCCHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8901102 [H]