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The map label for this gene is mtnP [H]

Identifier: 78778688

GI number: 78778688

Start: 287037

End: 287930

Strand: Reverse

Name: mtnP [H]

Synonym: PMT9312_0303

Alternate gene names: 78778688

Gene position: 287930-287037 (Counterclockwise)

Preceding gene: 78778690

Following gene: 78778681

Centisome position: 16.85

GC content: 34.45

Gene sequence:

>894_bases
ATGAATAAAGAACATTTATTACCAATTGAAAAATCAAGATTAGGAGTGATTGGTGGAAGTGGATTTTATTCAATGGATCA
AATAGAGTACTTAAGAGAAATAGAAATCAATACTCCCTATGGTAAACCTTCTGATTCAATAAAAGTATATAATCTTGGAA
ACCTAGAGATAGCATTCATTCCTCGACATGGCAGAACACATAGTTTAAATCCTTCTGAAATCCCTTACAAAGCTAATATT
TGGGCTCTAAGATCAATAGGAGTAAGATGGATTATTGCTCCATCAGCAGTTGGTTCATTACAAGAACAGATAAGGCCACT
TGATATAGTAGTTCCAGATCAATTTATAGATCGGACAAAAAATAGACCTGCAACCTTCTTTAACGAGGGAGCTGTTGCTC
ACATAACTATGGGAGATCCCTTCTGCACAAATTTATCACGTATATTAAGTGAAATCGCAGAAAAAAATATTCCTGGCGGT
AGACAATTGCATAGAGGGGGTACCTATCTAGCAATGGAAGGTCCCGCTTTCTCAACTAGAGCAGAATCTAATTTATATAG
GAGTTGGGGATGTTCAATAATTGGAATGACGAACCACACAGAAGCAAGATTAGCTAAAGAAGCTGAAATAGCTTACTCCT
CCTTATCTATGGTTACTGATTATGATTGCTGGAATCAAACTCATCAAGAAGTTTCTGTAGAGATGGTTTTGGATAATCTT
AGATCAAATACTGAAGTGGCTAATAAAATAATATTTGAAGTAGCTAAATTAATTGAAAAAGAAAGACCAAAAAGCAAGTC
TCATTTTTCATTAAAAGATGGATTGATAACCCAAAAAGAAAATATCCCAAGCTCCACGAAAGAGAAACTAAGGATATTTA
CTGATTCTTATTAG

Upstream 100 bases:

>100_bases
TGGCATTAATTTCGGAAACATTAACCATTTCTTTAATAAAGAAACATTTGAGTGTCCTCCTCCAATTAGTACCAGATGAT
TAAAAGTCATTTACATCACT

Downstream 100 bases:

>100_bases
GCTTATTTGATATAAGTGATTATCAGTCCAAGGTAAGGATTTGTTAGCCTCCAGCTCCAACACCTTGGTATGAACCATAG
AAGAATATTCCTAATACGAA

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNKEHLLPIEKSRLGVIGGSGFYSMDQIEYLREIEINTPYGKPSDSIKVYNLGNLEIAFIPRHGRTHSLNPSEIPYKANI
WALRSIGVRWIIAPSAVGSLQEQIRPLDIVVPDQFIDRTKNRPATFFNEGAVAHITMGDPFCTNLSRILSEIAEKNIPGG
RQLHRGGTYLAMEGPAFSTRAESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQTHQEVSVEMVLDNL
RSNTEVANKIIFEVAKLIEKERPKSKSHFSLKDGLITQKENIPSSTKEKLRIFTDSY

Sequences:

>Translated_297_residues
MNKEHLLPIEKSRLGVIGGSGFYSMDQIEYLREIEINTPYGKPSDSIKVYNLGNLEIAFIPRHGRTHSLNPSEIPYKANI
WALRSIGVRWIIAPSAVGSLQEQIRPLDIVVPDQFIDRTKNRPATFFNEGAVAHITMGDPFCTNLSRILSEIAEKNIPGG
RQLHRGGTYLAMEGPAFSTRAESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQTHQEVSVEMVLDNL
RSNTEVANKIIFEVAKLIEKERPKSKSHFSLKDGLITQKENIPSSTKEKLRIFTDSY
>Mature_297_residues
MNKEHLLPIEKSRLGVIGGSGFYSMDQIEYLREIEINTPYGKPSDSIKVYNLGNLEIAFIPRHGRTHSLNPSEIPYKANI
WALRSIGVRWIIAPSAVGSLQEQIRPLDIVVPDQFIDRTKNRPATFFNEGAVAHITMGDPFCTNLSRILSEIAEKNIPGG
RQLHRGGTYLAMEGPAFSTRAESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQTHQEVSVEMVLDNL
RSNTEVANKIIFEVAKLIEKERPKSKSHFSLKDGLITQKENIPSSTKEKLRIFTDSY

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=245, Percent_Identity=42.8571428571429, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71980569, Length=255, Percent_Identity=38.0392156862745, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323045, Length=302, Percent_Identity=36.7549668874172, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20130079, Length=261, Percent_Identity=39.8467432950192, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI221459247, Length=259, Percent_Identity=32.8185328185328, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 33474; Mature: 33474

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEHLLPIEKSRLGVIGGSGFYSMDQIEYLREIEINTPYGKPSDSIKVYNLGNLEIAFI
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHEECCCCCCCCCCCEEEEEECCEEEEEE
PRHGRTHSLNPSEIPYKANIWALRSIGVRWIIAPSAVGSLQEQIRPLDIVVPDQFIDRTK
ECCCCCCCCCCCCCCEECCEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECHHHHHHCC
NRPATFFNEGAVAHITMGDPFCTNLSRILSEIAEKNIPGGRQLHRGGTYLAMEGPAFSTR
CCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCH
AESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQTHQEVSVEMVLDNL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RSNTEVANKIIFEVAKLIEKERPKSKSHFSLKDGLITQKENIPSSTKEKLRIFTDSY
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEHHCCCEECCCCCCCCCHHHEEEEECCC
>Mature Secondary Structure
MNKEHLLPIEKSRLGVIGGSGFYSMDQIEYLREIEINTPYGKPSDSIKVYNLGNLEIAFI
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHEECCCCCCCCCCCEEEEEECCEEEEEE
PRHGRTHSLNPSEIPYKANIWALRSIGVRWIIAPSAVGSLQEQIRPLDIVVPDQFIDRTK
ECCCCCCCCCCCCCCEECCEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECHHHHHHCC
NRPATFFNEGAVAHITMGDPFCTNLSRILSEIAEKNIPGGRQLHRGGTYLAMEGPAFSTR
CCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCH
AESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWNQTHQEVSVEMVLDNL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RSNTEVANKIIFEVAKLIEKERPKSKSHFSLKDGLITQKENIPSSTKEKLRIFTDSY
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEHHCCCEECCCCCCCCCHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA