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The map label for this gene is folK [C]

Identifier: 78778674

GI number: 78778674

Start: 277005

End: 277571

Strand: Reverse

Name: folK [C]

Synonym: PMT9312_0289

Alternate gene names: 78778674

Gene position: 277571-277005 (Counterclockwise)

Preceding gene: 78778676

Following gene: 78778673

Centisome position: 16.24

GC content: 32.28

Gene sequence:

>567_bases
GTGGAATTATCAAATCTTAATATCAAAAATGGACTATGTATATCCCTAGGAGCAAATATTGATAGTAAATTCGGAAGCCC
TCTTGAGTCACTATTAATTTGCAAACCAAAAATAGAAGAAATAATAAATGAGTGGGGCGATCATTCCAACAAAAAAAAAG
AAGAGAAAAGAAAATTTCATGCAAACTTTTTTTGGTCTTCAATTTATGAGACATTACCTCATGGAGTTGAGAATGAACAG
CCCAATTATTTAAATACTCTTTTGCTCATAAAAAGTAATTCTTTTCCAAAACCATCAAATAAAAAGGCGAAATTACTTTT
AAAAGAACTAAAAAAGTTAGAGAGATCTTTCGGAAGAGAAAAGACGCCAAAGGGTAAGAAATGGCTATCAAGATGTCTCG
ATTTAGATATTCTCTGGTGGGAAGATTTTCATACGGTTGACGAGGAATTAACATTACCTCACCCTAGATTCATGAACCGA
AATTTCGTTATTACACCACTATCTGAGATCTTAAGTAGAAGCCAAAAAATCAAAAAGTTTGATGACCCAAAATGGTCTAT
CAAATGA

Upstream 100 bases:

>100_bases
TCATTAAATCCTTTATCTCTCCTTTTTCTGTTAACTCGGGGTTCAAAATCACTTTAAAAATGCCTGATATAGAATTTATC
CAATAACTTTGTTTTTTGTA

Downstream 100 bases:

>100_bases
TTTACAAAACCAAAAAATAACTGTTAGGCTATTTTTATTTTAAAATTATGGGCAATAAAAACTTTATAAAAAAATCCATT
TTTAAAGAAAAAATATCTGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: AMP; 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

Alternate protein names: NA

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MELSNLNIKNGLCISLGANIDSKFGSPLESLLICKPKIEEIINEWGDHSNKKKEEKRKFHANFFWSSIYETLPHGVENEQ
PNYLNTLLLIKSNSFPKPSNKKAKLLLKELKKLERSFGREKTPKGKKWLSRCLDLDILWWEDFHTVDEELTLPHPRFMNR
NFVITPLSEILSRSQKIKKFDDPKWSIK

Sequences:

>Translated_188_residues
MELSNLNIKNGLCISLGANIDSKFGSPLESLLICKPKIEEIINEWGDHSNKKKEEKRKFHANFFWSSIYETLPHGVENEQ
PNYLNTLLLIKSNSFPKPSNKKAKLLLKELKKLERSFGREKTPKGKKWLSRCLDLDILWWEDFHTVDEELTLPHPRFMNR
NFVITPLSEILSRSQKIKKFDDPKWSIK
>Mature_188_residues
MELSNLNIKNGLCISLGANIDSKFGSPLESLLICKPKIEEIINEWGDHSNKKKEEKRKFHANFFWSSIYETLPHGVENEQ
PNYLNTLLLIKSNSFPKPSNKKAKLLLKELKKLERSFGREKTPKGKKWLSRCLDLDILWWEDFHTVDEELTLPHPRFMNR
NFVITPLSEILSRSQKIKKFDDPKWSIK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.6.3

Molecular weight: Translated: 22065; Mature: 22065

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSNLNIKNGLCISLGANIDSKFGSPLESLLICKPKIEEIINEWGDHSNKKKEEKRKFH
CCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHH
ANFFWSSIYETLPHGVENEQPNYLNTLLLIKSNSFPKPSNKKAKLLLKELKKLERSFGRE
HHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
KTPKGKKWLSRCLDLDILWWEDFHTVDEELTLPHPRFMNRNFVITPLSEILSRSQKIKKF
CCCCHHHHHHHHHCCCEEECCCHHHCCHHCCCCCCHHHCCCEEEECHHHHHHHHHHHHHC
DDPKWSIK
CCCCCCCC
>Mature Secondary Structure
MELSNLNIKNGLCISLGANIDSKFGSPLESLLICKPKIEEIINEWGDHSNKKKEEKRKFH
CCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHH
ANFFWSSIYETLPHGVENEQPNYLNTLLLIKSNSFPKPSNKKAKLLLKELKKLERSFGRE
HHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
KTPKGKKWLSRCLDLDILWWEDFHTVDEELTLPHPRFMNRNFVITPLSEILSRSQKIKKF
CCCCHHHHHHHHHCCCEEECCCHHHCCHHCCCCCCHHHCCCEEEECHHHHHHHHHHHHHC
DDPKWSIK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {ATP}} 0.017 {ATP}} [C]

Substrates: ATP; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine

Specific reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

General reaction: Diphsphate transfer [C]

Inhibitor: 2-Amino-4-hydroxy -6-carboxydihydropteridine [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA