| Definition | Prochlorococcus marinus str. MIT 9312, complete genome. |
|---|---|
| Accession | NC_007577 |
| Length | 1,709,204 |
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The map label for this gene is purH
Identifier: 78778653
GI number: 78778653
Start: 256469
End: 258022
Strand: Reverse
Name: purH
Synonym: PMT9312_0268
Alternate gene names: 78778653
Gene position: 258022-256469 (Counterclockwise)
Preceding gene: 78778655
Following gene: 78778648
Centisome position: 15.1
GC content: 32.95
Gene sequence:
>1554_bases ATGTCACCATTAGCTTTAGTAAGTGTCTCAGATAAAAAACATATAGTCCCATTTTGTATGGAATTGGTAGAACAATTTAA TTATAGAATTCTATCAAGTGGAGGAACTGCCAAACATCTAATAGAGGCAAATATTCCAGTTATTAAAGTTGCAGATTTTA CTAATTCTCCAGAAATCCTTGGAGGAAGAGTGAAAACTTTACATCCAAAAATACACGGAGGAATATTAGCTAAAAGAACT GATGAAGAACATAAAAGAGATATAGAAGCTAACGATCTTGAGTTAATTGACTTAGTAGTTGTCAATTTATATCCTTTTAA GAAAACTGTAGAACAGGGATCTAAATGGGAAGATTCTATTGAAAATATCGATATAGGAGGGCCATCAATGATTCGTTCTG CAGCTAAAAATCATAAAGACGTTTCTGTTTTAGTCGATCCTAGTCAATATCAGAATTTTCTTGAAGAAAGTAAAAAAGGT GAGTTAAAGGATTCATATAAAGCACAATTAGCCCTTGAAGCTTTTCAACATACAGCAGACTATGACACTGCAATATCTAA TTGGATAAGTAAAGAAAGAGGTTTACAATCCTCTAAATATATTGAATCTTATCCACTAATCAACACCTTAAGATATGGGG AGAATCCTCATCAAAAAGCTTTGTGGTATGGTTTGAGTAATATTGGATGGAACTCAGCAGAACAATTACAAGGTAAAGAT TTAAGTTATAACAATTTATTAGATCTTGAGTCAGCACTTTCAACAGTTTTAGAATTTGGCTATGCAGAAAAAGATGAACT TACTACAGATACGTTTGCATCTGTTATTCTAAAACACAATAATCCTTGTGGTGCCTCTATAAGTAATTCAGCCTCTCAAG CATTTTTGAATGCTTTGGAATGCGACTCAGTTAGTGCATTTGGAGGAATAGTTGCTTTTAATTCAAATGTTGATAGTGAA ACCGCAATTAACCTCAAAGATATTTTCCTAGAGTGTGTCGTAGCTCCATCTTTTGATGCGGAAGCTTTAGAAATTTTAAA AATCAAAAAGAATTTAAGAATTTTAAAGTTATCAAAAGATCAACTCCCAAAAAAGAAGCAAACTTCTACTAAATCAATAA TGGGAGGATTACTTGTTCAAGACACTAATGATAGTGAAGATAAAACTGAAAGTTGGATGTCAGTAACTAAGAATAATCCG AGTAATCAAATGAACTTAGATCTAAATTTTGCATGGAAAATTTGTAAACATGTGAAATCGAATGCGATTGTTATTGCAAA AGACCAAAAAACTATTGGTATAGGAGCTGGACAAATGAATAGAGTTGGAGCAGCAAAAATCGCATTACAAGCAGCTGGAA AGTTATGTTCTGATGCTGTCTTGGCCAGTGATGGGTTTTTTCCATTTGCAGATACTGTAGAACTTGCAAATGAGTATGGT ATAAAAGCAATTATCCAACCTGGAGGGAGTCTAAGAGACCAAGAAAGTATTGATATGTGTAATTCTAAAGGAATCTCAAT GGTAATTACGCAAAAAAGGCATTTTTTGCATTAG
Upstream 100 bases:
>100_bases AAATAATTCTATGAGTTGCAGTTTGAGAGCTAATCGAGACAAATTCATGATGGATATCGTATTTCATGTTTATATTCTTA AGTAAATAAACTTTCTCATA
Downstream 100 bases:
>100_bases GTTAGTTATGTTGATTTTGGATAATATGTAATCTTGTTAGTCTTTCTGAATAAAGAGAGCCTGCCTGGACCTGCGCATAG AAAATAGAGAGAAATAGCAC
Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 517; Mature: 516
Protein sequence:
>517_residues MSPLALVSVSDKKHIVPFCMELVEQFNYRILSSGGTAKHLIEANIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAKRT DEEHKRDIEANDLELIDLVVVNLYPFKKTVEQGSKWEDSIENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKG ELKDSYKAQLALEAFQHTADYDTAISNWISKERGLQSSKYIESYPLINTLRYGENPHQKALWYGLSNIGWNSAEQLQGKD LSYNNLLDLESALSTVLEFGYAEKDELTTDTFASVILKHNNPCGASISNSASQAFLNALECDSVSAFGGIVAFNSNVDSE TAINLKDIFLECVVAPSFDAEALEILKIKKNLRILKLSKDQLPKKKQTSTKSIMGGLLVQDTNDSEDKTESWMSVTKNNP SNQMNLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALQAAGKLCSDAVLASDGFFPFADTVELANEYG IKAIIQPGGSLRDQESIDMCNSKGISMVITQKRHFLH
Sequences:
>Translated_517_residues MSPLALVSVSDKKHIVPFCMELVEQFNYRILSSGGTAKHLIEANIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAKRT DEEHKRDIEANDLELIDLVVVNLYPFKKTVEQGSKWEDSIENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKG ELKDSYKAQLALEAFQHTADYDTAISNWISKERGLQSSKYIESYPLINTLRYGENPHQKALWYGLSNIGWNSAEQLQGKD LSYNNLLDLESALSTVLEFGYAEKDELTTDTFASVILKHNNPCGASISNSASQAFLNALECDSVSAFGGIVAFNSNVDSE TAINLKDIFLECVVAPSFDAEALEILKIKKNLRILKLSKDQLPKKKQTSTKSIMGGLLVQDTNDSEDKTESWMSVTKNNP SNQMNLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALQAAGKLCSDAVLASDGFFPFADTVELANEYG IKAIIQPGGSLRDQESIDMCNSKGISMVITQKRHFLH >Mature_516_residues SPLALVSVSDKKHIVPFCMELVEQFNYRILSSGGTAKHLIEANIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAKRTD EEHKRDIEANDLELIDLVVVNLYPFKKTVEQGSKWEDSIENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKGE LKDSYKAQLALEAFQHTADYDTAISNWISKERGLQSSKYIESYPLINTLRYGENPHQKALWYGLSNIGWNSAEQLQGKDL SYNNLLDLESALSTVLEFGYAEKDELTTDTFASVILKHNNPCGASISNSASQAFLNALECDSVSAFGGIVAFNSNVDSET AINLKDIFLECVVAPSFDAEALEILKIKKNLRILKLSKDQLPKKKQTSTKSIMGGLLVQDTNDSEDKTESWMSVTKNNPS NQMNLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALQAAGKLCSDAVLASDGFFPFADTVELANEYGI KAIIQPGGSLRDQESIDMCNSKGISMVITQKRHFLH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=478, Percent_Identity=37.2384937238494, Blast_Score=233, Evalue=3e-61, Organism=Escherichia coli, GI1790439, Length=537, Percent_Identity=45.2513966480447, Blast_Score=412, Evalue=1e-116, Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=35.0210970464135, Blast_Score=239, Evalue=3e-63, Organism=Caenorhabditis elegans, GI71985574, Length=304, Percent_Identity=27.3026315789474, Blast_Score=86, Evalue=4e-17, Organism=Saccharomyces cerevisiae, GI6323056, Length=473, Percent_Identity=36.1522198731501, Blast_Score=252, Evalue=1e-67, Organism=Saccharomyces cerevisiae, GI6323768, Length=469, Percent_Identity=36.0341151385927, Blast_Score=252, Evalue=1e-67, Organism=Drosophila melanogaster, GI24649832, Length=477, Percent_Identity=34.8008385744235, Blast_Score=225, Evalue=7e-59,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 56960; Mature: 56829
Theoretical pI: Translated: 6.11; Mature: 6.11
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSPLALVSVSDKKHIVPFCMELVEQFNYRILSSGGTAKHLIEANIPVIKVADFTNSPEIL CCCEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCHHEEECCCCEEEEECCCCCCHHH GGRVKTLHPKIHGGILAKRTDEEHKRDIEANDLELIDLVVVNLYPFKKTVEQGSKWEDSI CCCEEEECCHHHCCEEECCCCHHHHCCCCCCCCEEEEEEEHHCCCHHHHHHCCCCHHHHH ENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKGELKDSYKAQLALEAFQHTAD CEECCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC YDTAISNWISKERGLQSSKYIESYPLINTLRYGENPHQKALWYGLSNIGWNSAEQLQGKD HHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHCCCC LSYNNLLDLESALSTVLEFGYAEKDELTTDTFASVILKHNNPCGASISNSASQAFLNALE CCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC CDSVSAFGGIVAFNSNVDSETAINLKDIFLECVVAPSFDAEALEILKIKKNLRILKLSKD CCCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECHH QLPKKKQTSTKSIMGGLLVQDTNDSEDKTESWMSVTKNNPSNQMNLDLNFAWKICKHVKS HCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCC NAIVIAKDQKTIGIGAGQMNRVGAAKIALQAAGKLCSDAVLASDGFFPFADTVELANEYG CEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCC IKAIIQPGGSLRDQESIDMCNSKGISMVITQKRHFLH CEEEECCCCCCCCCHHHHHHCCCCCEEEEECCHHCCC >Mature Secondary Structure SPLALVSVSDKKHIVPFCMELVEQFNYRILSSGGTAKHLIEANIPVIKVADFTNSPEIL CCEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCHHEEECCCCEEEEECCCCCCHHH GGRVKTLHPKIHGGILAKRTDEEHKRDIEANDLELIDLVVVNLYPFKKTVEQGSKWEDSI CCCEEEECCHHHCCEEECCCCHHHHCCCCCCCCEEEEEEEHHCCCHHHHHHCCCCHHHHH ENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKGELKDSYKAQLALEAFQHTAD CEECCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC YDTAISNWISKERGLQSSKYIESYPLINTLRYGENPHQKALWYGLSNIGWNSAEQLQGKD HHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHCCCC LSYNNLLDLESALSTVLEFGYAEKDELTTDTFASVILKHNNPCGASISNSASQAFLNALE CCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC CDSVSAFGGIVAFNSNVDSETAINLKDIFLECVVAPSFDAEALEILKIKKNLRILKLSKD CCCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECHH QLPKKKQTSTKSIMGGLLVQDTNDSEDKTESWMSVTKNNPSNQMNLDLNFAWKICKHVKS HCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCC NAIVIAKDQKTIGIGAGQMNRVGAAKIALQAAGKLCSDAVLASDGFFPFADTVELANEYG CEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHCC IKAIIQPGGSLRDQESIDMCNSKGISMVITQKRHFLH CEEEECCCCCCCCCHHHHHHCCCCCEEEEECCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA