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The map label for this gene is mrdA [H]

Identifier: 78778426

GI number: 78778426

Start: 40011

End: 41801

Strand: Direct

Name: mrdA [H]

Synonym: PMT9312_0041

Alternate gene names: 78778426

Gene position: 40011-41801 (Clockwise)

Preceding gene: 78778425

Following gene: 78778430

Centisome position: 2.34

GC content: 33.11

Gene sequence:

>1791_bases
TTGATCAAAAGACCGTATAGTAAAAAACTTATTTCATTCAAGAGACAACCGTTAGTCTTACTTATCTTTTCCTCGATTTC
ATTTCTATTGATTTTGTTACGGTTGATTTTTTTACAACTATTAAATTACGAATCTTTTAAGAAAATGTCTGATGAGAACA
GGATTAGACTTATCGCTTCACAACCAATACGCGGAAGAATACTTGATAAAAATGGTAAGGTTCTAGCAGATAGTAGAGTG
AAATATTCTCTAATAATAAAACCTCAATCGGTAAATGAAAGCGATTGGGAAAAACATAAAGTAATTATTTCTGACTTTTT
AAATATTGATAAAAATTTAATTCAAACAAAATATTTTGATGGTTTAAAAAAGCAGAAACTTGCAGTAACTATTATTGATG
ATTTAAGTGTGGATCAATTAATAAAATTTAAGGAAAATGAAGATAATTTATTTAGTTTTGAAATAGCGACGAAATTAATT
AGAAATTATCCTTATAAATCACTAGCTGCTCACGTAATTGGATATACACAACCAATTACTGAGTCAGAATACAAATTTTT
ATCTAAAAAGGGTTATAAATTAAATGACTTAATTGGTAGAACTGGCATTGAATATGTTTACGAAGACTTCATAAGAGGTG
AATGGGGCGGAGAGATGGTTGAAGTGAATTCTTTAGGAAAATTCCAAAGATCCTTGGGGGTTAAACCCTCCAGACAAGGT
AACGATATTGAATTGACTATTGATATGGACTTGCAATTAATTGCCGAGGAAGTTCTTAACGACAAAAAAGCTGGAGCGAT
AATAGTGATTGATCCAAGAGATGGTGCAATAAAGGCAATGGCAAGTAGGCCTACTTTTGATTTGAATTTTTTTTCAAAGG
ATTTTAAGCCTGAAAAAGAATATGATAAGTTATTCAACTCTCCTGAAAAACCTCTTTTCAATAGAGCATTAAATGCTTAT
GATCCCGGAAGTGTTTGGAAGATTGTAACGGCTTTAGCTGGCTTAGAAAGTGGAAAATTTCCTATTGATACTATGTTAGA
AACTAAACCATGTATAACTTATGGGAGTCAATGTTTTAGGGAACATAATGATTTAGGCTTTGGGGTAATAGGTTATGAAG
ATGCATTAAGAGTTTCAAGTAATACTTTTTTTTATCAAGTCGGATATGGAGTAGGTGTTGATGCAATTCATAAGGTCTCT
AGAAAGCTTGGTTTTAATTCTTTATCTGGAATTGAAATTTCTGAACAAGAAAATATAGGATTAGTAGCAAGTAGCAAATG
GGCTAAAGAAGGGCGGGGATGGGGCGAACCAGGTAGAACTCCTTGGGTTCCAGAAGATATTGCGAGTATGTCTATTGGAC
AATTTGTTGTTCAAGTTACTCCTATTCAATTAGCTAGAGCATATGCTGCTATTGCAAATGGAGGTTATCTAGTTACTCCT
CATTTAGTTAAAAAAGATGATGAAAATATTTCACACAAAAAACGTATTAAAATTGATGTTGATCCAAAAAATATTCAGTT
GATAAAAGACGGTCTGAGGAAAGTAGTAGAGTCTGGCACAGGAGTATCCATTAATTATGGAGTTTCAAATTTACCTCCAG
TTTCAGGTAAAACTGGAACTGCTGAAGATGGTGAAGGCGGCTTAGATCACGCTTGGTTCGTTTGCTTTACTCCTTCTGAA
AAAAGTGAGTTGCTTGTAGTCGCTTTTGCTCAAAATACTCCTGGTGGAGGCTCTGTACATGCACTTCCTATGGCTAGACA
AATTTTAAAAGTTTGGAATGAAAAAAATTGA

Upstream 100 bases:

>100_bases
ATGAAGAGAGAGATTATAAAAATTTAATCACCAGGCTAAAAGATATAAGTTCAACCATTGCTTTATTAGAAAAAACAATA
TTTAGATAAATTTTAAATTT

Downstream 100 bases:

>100_bases
TATTTAGTTTTATTTTTAAAGTTTATGTTTTTATCTTTTTCATTTGTAAAAGTCTTTGAATAATATCTTCAATAGTTTTT
GTATCTATAGGTTTACTATA

Product: putative penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MIKRPYSKKLISFKRQPLVLLIFSSISFLLILLRLIFLQLLNYESFKKMSDENRIRLIASQPIRGRILDKNGKVLADSRV
KYSLIIKPQSVNESDWEKHKVIISDFLNIDKNLIQTKYFDGLKKQKLAVTIIDDLSVDQLIKFKENEDNLFSFEIATKLI
RNYPYKSLAAHVIGYTQPITESEYKFLSKKGYKLNDLIGRTGIEYVYEDFIRGEWGGEMVEVNSLGKFQRSLGVKPSRQG
NDIELTIDMDLQLIAEEVLNDKKAGAIIVIDPRDGAIKAMASRPTFDLNFFSKDFKPEKEYDKLFNSPEKPLFNRALNAY
DPGSVWKIVTALAGLESGKFPIDTMLETKPCITYGSQCFREHNDLGFGVIGYEDALRVSSNTFFYQVGYGVGVDAIHKVS
RKLGFNSLSGIEISEQENIGLVASSKWAKEGRGWGEPGRTPWVPEDIASMSIGQFVVQVTPIQLARAYAAIANGGYLVTP
HLVKKDDENISHKKRIKIDVDPKNIQLIKDGLRKVVESGTGVSINYGVSNLPPVSGKTGTAEDGEGGLDHAWFVCFTPSE
KSELLVVAFAQNTPGGGSVHALPMARQILKVWNEKN

Sequences:

>Translated_596_residues
MIKRPYSKKLISFKRQPLVLLIFSSISFLLILLRLIFLQLLNYESFKKMSDENRIRLIASQPIRGRILDKNGKVLADSRV
KYSLIIKPQSVNESDWEKHKVIISDFLNIDKNLIQTKYFDGLKKQKLAVTIIDDLSVDQLIKFKENEDNLFSFEIATKLI
RNYPYKSLAAHVIGYTQPITESEYKFLSKKGYKLNDLIGRTGIEYVYEDFIRGEWGGEMVEVNSLGKFQRSLGVKPSRQG
NDIELTIDMDLQLIAEEVLNDKKAGAIIVIDPRDGAIKAMASRPTFDLNFFSKDFKPEKEYDKLFNSPEKPLFNRALNAY
DPGSVWKIVTALAGLESGKFPIDTMLETKPCITYGSQCFREHNDLGFGVIGYEDALRVSSNTFFYQVGYGVGVDAIHKVS
RKLGFNSLSGIEISEQENIGLVASSKWAKEGRGWGEPGRTPWVPEDIASMSIGQFVVQVTPIQLARAYAAIANGGYLVTP
HLVKKDDENISHKKRIKIDVDPKNIQLIKDGLRKVVESGTGVSINYGVSNLPPVSGKTGTAEDGEGGLDHAWFVCFTPSE
KSELLVVAFAQNTPGGGSVHALPMARQILKVWNEKN
>Mature_596_residues
MIKRPYSKKLISFKRQPLVLLIFSSISFLLILLRLIFLQLLNYESFKKMSDENRIRLIASQPIRGRILDKNGKVLADSRV
KYSLIIKPQSVNESDWEKHKVIISDFLNIDKNLIQTKYFDGLKKQKLAVTIIDDLSVDQLIKFKENEDNLFSFEIATKLI
RNYPYKSLAAHVIGYTQPITESEYKFLSKKGYKLNDLIGRTGIEYVYEDFIRGEWGGEMVEVNSLGKFQRSLGVKPSRQG
NDIELTIDMDLQLIAEEVLNDKKAGAIIVIDPRDGAIKAMASRPTFDLNFFSKDFKPEKEYDKLFNSPEKPLFNRALNAY
DPGSVWKIVTALAGLESGKFPIDTMLETKPCITYGSQCFREHNDLGFGVIGYEDALRVSSNTFFYQVGYGVGVDAIHKVS
RKLGFNSLSGIEISEQENIGLVASSKWAKEGRGWGEPGRTPWVPEDIASMSIGQFVVQVTPIQLARAYAAIANGGYLVTP
HLVKKDDENISHKKRIKIDVDPKNIQLIKDGLRKVVESGTGVSINYGVSNLPPVSGKTGTAEDGEGGLDHAWFVCFTPSE
KSELLVVAFAQNTPGGGSVHALPMARQILKVWNEKN

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=613, Percent_Identity=29.2006525285481, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1786272, Length=555, Percent_Identity=23.0630630630631, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66822; Mature: 66822

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRPYSKKLISFKRQPLVLLIFSSISFLLILLRLIFLQLLNYESFKKMSDENRIRLIAS
CCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEC
QPIRGRILDKNGKVLADSRVKYSLIIKPQSVNESDWEKHKVIISDFLNIDKNLIQTKYFD
CCCCCEEECCCCCEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHC
GLKKQKLAVTIIDDLSVDQLIKFKENEDNLFSFEIATKLIRNYPYKSLAAHVIGYTQPIT
CCCCCEEEEEEECCCCHHHHHHHCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCCCCC
ESEYKFLSKKGYKLNDLIGRTGIEYVYEDFIRGEWGGEMVEVNSLGKFQRSLGVKPSRQG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHCCCCCCCC
NDIELTIDMDLQLIAEEVLNDKKAGAIIVIDPRDGAIKAMASRPTFDLNFFSKDFKPEKE
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHCCCCEEEECCCCCCCCCHH
YDKLFNSPEKPLFNRALNAYDPGSVWKIVTALAGLESGKFPIDTMLETKPCITYGSQCFR
HHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHH
EHNDLGFGVIGYEDALRVSSNTFFYQVGYGVGVDAIHKVSRKLGFNSLSGIEISEQENIG
HCCCCCEEEECCHHHHEECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCE
LVASSKWAKEGRGWGEPGRTPWVPEDIASMSIGQFVVQVTPIQLARAYAAIANGGYLVTP
EEECCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECHHHHHHHHHHHHCCCEEECC
HLVKKDDENISHKKRIKIDVDPKNIQLIKDGLRKVVESGTGVSINYGVSNLPPVSGKTGT
HHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
AEDGEGGLDHAWFVCFTPSEKSELLVVAFAQNTPGGGSVHALPMARQILKVWNEKN
CCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKRPYSKKLISFKRQPLVLLIFSSISFLLILLRLIFLQLLNYESFKKMSDENRIRLIAS
CCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEC
QPIRGRILDKNGKVLADSRVKYSLIIKPQSVNESDWEKHKVIISDFLNIDKNLIQTKYFD
CCCCCEEECCCCCEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHC
GLKKQKLAVTIIDDLSVDQLIKFKENEDNLFSFEIATKLIRNYPYKSLAAHVIGYTQPIT
CCCCCEEEEEEECCCCHHHHHHHCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCCCCC
ESEYKFLSKKGYKLNDLIGRTGIEYVYEDFIRGEWGGEMVEVNSLGKFQRSLGVKPSRQG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHCCCCCCCC
NDIELTIDMDLQLIAEEVLNDKKAGAIIVIDPRDGAIKAMASRPTFDLNFFSKDFKPEKE
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHCCCCEEEECCCCCCCCCHH
YDKLFNSPEKPLFNRALNAYDPGSVWKIVTALAGLESGKFPIDTMLETKPCITYGSQCFR
HHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHH
EHNDLGFGVIGYEDALRVSSNTFFYQVGYGVGVDAIHKVSRKLGFNSLSGIEISEQENIG
HCCCCCEEEECCHHHHEECCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCE
LVASSKWAKEGRGWGEPGRTPWVPEDIASMSIGQFVVQVTPIQLARAYAAIANGGYLVTP
EEECCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECHHHHHHHHHHHHCCCEEECC
HLVKKDDENISHKKRIKIDVDPKNIQLIKDGLRKVVESGTGVSINYGVSNLPPVSGKTGT
HHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
AEDGEGGLDHAWFVCFTPSEKSELLVVAFAQNTPGGGSVHALPMARQILKVWNEKN
CCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]