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The map label for this gene is purL [H]

Identifier: 78778388

GI number: 78778388

Start: 2072

End: 4411

Strand: Direct

Name: purL [H]

Synonym: PMT9312_0003

Alternate gene names: 78778388

Gene position: 2072-4411 (Clockwise)

Preceding gene: 78778387

Following gene: 78778389

Centisome position: 0.12

GC content: 31.84

Gene sequence:

>2340_bases
ATGATAAATCCAGACAATAATGATCTTTATGATCTTAATGAAGCGCTTAAAGTTGAAAATTTAACAATTAATGATTACGA
GGAAATTTGCAAAAGATTAAAGAGAAAACCTAATAGGACTGAACTAGGAATGTTTGGTGTTATGTGGTCTGAACATTGTT
GTTATAGGAATTCCAAACCTTTACTATCAAATTTTCCTACTAAAGGAAAAAACATTTTGGTTGGCCCTGGAGAAAACGCT
GGTGTTATTGATGTTGGAAATAATCAAAAACTTGTTTTTAAAATAGAAAGTCATAATCATCCCTCTGCAATTGAACCTTT
TCAAGGAGCCGCAACAGGAGTAGGAGGAATATTAAGAGATATTTTTACAATGGGAGCAAGGCCAATCGCAGTATTGAATT
CATTGAGATTTGGAAATCTTGATAAGACATCAAATATGGATTTACTTCGAGGAGTTGTATCAGGTATTGCACATTATGGA
AATTGTGTAGGTGTTCCTACTGTTGGAGGTGAGATTGACTTCGATGATAGTTATTCTGGAAATCCTCTAGTCAATGTTAT
GGCCTTAGGGCTTTTAGAGACTAATGAAATAGTTTGTTCTGGAGCTAAAAATGTAGGATCACCAGTACTATATGTTGGTA
ATACAACTGGTAGAGATGGTGTTGGTGGTGCTAGTTTCGCAAGTTCAGAATTAACTATTACTTCATTAGATGATAGACCT
GCAGTGCAAGTAGGTGATCCATTTATTGAGAAAAGTCTTATAGAAGCTTGTTTAGATGCTTTTAAGACAGGAGATGTAAT
TGCAGCTCAAGATATGGGTGCAGCAGGTTTAACCTGCAGTAGTGCAGAAATGGCCGCTAATGGAAACTTAGGTATATCTA
TTGATTTAGATTTAGTTCCTTCTAGAGAAGATAATATGTCTTCATACCAATATTTATTATCTGAATCTCAAGAGAGAATG
TTGTTTGTTGTAAAAGAAGAAAAAATTAATAATCTTATTGAGAAATTTAATAAATGGGGATTATATGCCAATGTAATTGG
TGAAGTAATAGAGACTAATGAGGTAATTATTTCTCATAAACGAAAAATTGTTGCTCAAATACCTACTTCTGCTCTATCTG
ATGATACGCCTGTTAATTTACATAATGTGATGAAAAATCCACCTAATTATTTGTTAAAGAAATGGAAATGGAATGAAAAT
AATTTACCAGAAATTAATGAGCAAAAAATATTTTCATTAAAGGAAAACAAAAGTTTTTCTTATTCGGAAATCATTTTAAA
ACTTCTCGCTAACCCATCAATAGCTTCTAAAAGATGGATTTATAAACAATATGACTCTCAAGTCCAGGCAAATACTGTTT
TTAAACCTGGAGAATCAGATGCTGCTGTAATAAGATTAAGAGAACAAAATGAAAAAAATAAAAGTAAAGTATTTTCTGGT
GTTGCTGCTTCAGTTGACTGTAATAGTAGATGGGTTTCTCTTGACCCTTTTAGAGGAACTATTGCTGCAGTTGCAGAATC
CGCAAGAAATGTGAGTTGTGTTGGAGCTGAACCAGTAGCAATTACAAATAATTTAAATTTTTCATCTCCTGAGACTGAAA
TTGGATATTGGCAACTTTCATCTTCATGCAATGCAATTTCTGAAGCCTGTAAAGCTTTAGAAACTCCAGTTACGGGAGGA
AATGTTTCCTTATATAATGAATCCAAAAATAGAGATAATGAAATTACTCCTATTAATCCGACTCCAGTTATTGGAATGGT
TGGGAAGATAGATAATGTTGAAAAAGCTATAAGTACTGAATGGAAAAATATTAATGATCAAATCTGGTTGATTGGCTCTC
ATAAATCAGAAACAACAATTGCAGCTAGTTCTTATTTGGAATATTTTCATGGAGAAATTACAGGTCGTCCTCCAAAAATA
GATTTACAGGATGAAAAGTTTTGCCAGAGTTTTTTAAGAAATGCGATTTTAAATAATTTTGTAGTTTCTTCTCATGATAT
TAGCGATGGGGGTTTAGCTATAGCTTTAGCAGAGTGTTGTATTTTGTCCGCAAAAGGCGCAACTATTGAATTAGAGAAAG
ATCTTAATAGAGATGATAATGTATTGTTTTCAGAAGGAGGTTCTAGAATTATTTTTTCAATAGATAAAATGAAGGAAAAA
GAATGGAGTAATTATCTAAAAAAGATTCAAATAAATTCTCAATCAAATGTATATGTAAAAAAAATAGGATATGTTTCGAG
TGAAATCCTTAAGATAAAAATCCAAGATAAAAATATCTGTGATATTAGTGTTGAGGAATTAACCGAAAAATTTAATAATA
GTATTTCAGGTTACTTTTAA

Upstream 100 bases:

>100_bases
TATAAACCAAAACTTAGGTTTTAAACAAAAAAGTTTTTATAATGATAAAACATCAAGATCTTTTAGTGATAAAAAAGAAG
ATGACCCTTGGATCTGAAGA

Downstream 100 bases:

>100_bases
ATATGAAATATACTTCTCAACTATCAAAATTTTTCAGTAATTAAGTTATGTGCGGAATAGTTGGAATCGTTTCTTCAGAT
GATGTAAATCAACAAATTTA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MINPDNNDLYDLNEALKVENLTINDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKPLLSNFPTKGKNILVGPGENA
GVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKTSNMDLLRGVVSGIAHYG
NCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETNEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTITSLDDRP
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVPSREDNMSSYQYLLSESQERM
LFVVKEEKINNLIEKFNKWGLYANVIGEVIETNEVIISHKRKIVAQIPTSALSDDTPVNLHNVMKNPPNYLLKKWKWNEN
NLPEINEQKIFSLKENKSFSYSEIILKLLANPSIASKRWIYKQYDSQVQANTVFKPGESDAAVIRLREQNEKNKSKVFSG
VAASVDCNSRWVSLDPFRGTIAAVAESARNVSCVGAEPVAITNNLNFSSPETEIGYWQLSSSCNAISEACKALETPVTGG
NVSLYNESKNRDNEITPINPTPVIGMVGKIDNVEKAISTEWKNINDQIWLIGSHKSETTIAASSYLEYFHGEITGRPPKI
DLQDEKFCQSFLRNAILNNFVVSSHDISDGGLAIALAECCILSAKGATIELEKDLNRDDNVLFSEGGSRIIFSIDKMKEK
EWSNYLKKIQINSQSNVYVKKIGYVSSEILKIKIQDKNICDISVEELTEKFNNSISGYF

Sequences:

>Translated_779_residues
MINPDNNDLYDLNEALKVENLTINDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKPLLSNFPTKGKNILVGPGENA
GVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKTSNMDLLRGVVSGIAHYG
NCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETNEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTITSLDDRP
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVPSREDNMSSYQYLLSESQERM
LFVVKEEKINNLIEKFNKWGLYANVIGEVIETNEVIISHKRKIVAQIPTSALSDDTPVNLHNVMKNPPNYLLKKWKWNEN
NLPEINEQKIFSLKENKSFSYSEIILKLLANPSIASKRWIYKQYDSQVQANTVFKPGESDAAVIRLREQNEKNKSKVFSG
VAASVDCNSRWVSLDPFRGTIAAVAESARNVSCVGAEPVAITNNLNFSSPETEIGYWQLSSSCNAISEACKALETPVTGG
NVSLYNESKNRDNEITPINPTPVIGMVGKIDNVEKAISTEWKNINDQIWLIGSHKSETTIAASSYLEYFHGEITGRPPKI
DLQDEKFCQSFLRNAILNNFVVSSHDISDGGLAIALAECCILSAKGATIELEKDLNRDDNVLFSEGGSRIIFSIDKMKEK
EWSNYLKKIQINSQSNVYVKKIGYVSSEILKIKIQDKNICDISVEELTEKFNNSISGYF
>Mature_779_residues
MINPDNNDLYDLNEALKVENLTINDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKPLLSNFPTKGKNILVGPGENA
GVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKTSNMDLLRGVVSGIAHYG
NCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETNEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTITSLDDRP
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVPSREDNMSSYQYLLSESQERM
LFVVKEEKINNLIEKFNKWGLYANVIGEVIETNEVIISHKRKIVAQIPTSALSDDTPVNLHNVMKNPPNYLLKKWKWNEN
NLPEINEQKIFSLKENKSFSYSEIILKLLANPSIASKRWIYKQYDSQVQANTVFKPGESDAAVIRLREQNEKNKSKVFSG
VAASVDCNSRWVSLDPFRGTIAAVAESARNVSCVGAEPVAITNNLNFSSPETEIGYWQLSSSCNAISEACKALETPVTGG
NVSLYNESKNRDNEITPINPTPVIGMVGKIDNVEKAISTEWKNINDQIWLIGSHKSETTIAASSYLEYFHGEITGRPPKI
DLQDEKFCQSFLRNAILNNFVVSSHDISDGGLAIALAECCILSAKGATIELEKDLNRDDNVLFSEGGSRIIFSIDKMKEK
EWSNYLKKIQINSQSNVYVKKIGYVSSEILKIKIQDKNICDISVEELTEKFNNSISGYF

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=783, Percent_Identity=22.3499361430396, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17553022, Length=679, Percent_Identity=22.5331369661267, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321498, Length=818, Percent_Identity=22.9828850855746, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 85621; Mature: 85621

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINPDNNDLYDLNEALKVENLTINDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKP
CCCCCCCCCCCCCHHHEEECCEECCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCC
LLSNFPTKGKNILVGPGENAGVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRD
HHHCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IFTMGARPIAVLNSLRFGNLDKTSNMDLLRGVVSGIAHYGNCVGVPTVGGEIDFDDSYSG
HHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCC
NPLVNVMALGLLETNEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTITSLDDRP
CCHHHHHHHHHEECCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCC
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVP
CEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCCHHCCCCCEEEEEEEEECC
SREDNMSSYQYLLSESQERMLFVVKEEKINNLIEKFNKWGLYANVIGEVIETNEVIISHK
CCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEHHH
RKIVAQIPTSALSDDTPVNLHNVMKNPPNYLLKKWKWNENNLPEINEQKIFSLKENKSFS
HHHEECCCCHHCCCCCCCCHHHHHCCCHHHHHEEEECCCCCCCCCCCHHEEEECCCCCCC
YSEIILKLLANPSIASKRWIYKQYDSQVQANTVFKPGESDAAVIRLREQNEKNKSKVFSG
HHHHHHHHHCCCCCCHHHHHHHHHCCCEEECEEECCCCCCEEEEEEECCCCCHHHHHHHC
VAASVDCNSRWVSLDPFRGTIAAVAESARNVSCVGAEPVAITNNLNFSSPETEIGYWQLS
CEEEECCCCCEEEECCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEC
SSCNAISEACKALETPVTGGNVSLYNESKNRDNEITPINPTPVIGMVGKIDNVEKAISTE
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHH
WKNINDQIWLIGSHKSETTIAASSYLEYFHGEITGRPPKIDLQDEKFCQSFLRNAILNNF
HCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHC
VVSSHDISDGGLAIALAECCILSAKGATIELEKDLNRDDNVLFSEGGSRIIFSIDKMKEK
EEECCCCCCCCHHHHHHHHHHEECCCCEEEECCCCCCCCCEEEECCCCEEEEEHHHHHHH
EWSNYLKKIQINSQSNVYVKKIGYVSSEILKIKIQDKNICDISVEELTEKFNNSISGYF
HHHHHHHEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MINPDNNDLYDLNEALKVENLTINDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKP
CCCCCCCCCCCCCHHHEEECCEECCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCC
LLSNFPTKGKNILVGPGENAGVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRD
HHHCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IFTMGARPIAVLNSLRFGNLDKTSNMDLLRGVVSGIAHYGNCVGVPTVGGEIDFDDSYSG
HHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCC
NPLVNVMALGLLETNEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTITSLDDRP
CCHHHHHHHHHEECCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCC
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVP
CEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCCHHCCCCCEEEEEEEEECC
SREDNMSSYQYLLSESQERMLFVVKEEKINNLIEKFNKWGLYANVIGEVIETNEVIISHK
CCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEHHH
RKIVAQIPTSALSDDTPVNLHNVMKNPPNYLLKKWKWNENNLPEINEQKIFSLKENKSFS
HHHEECCCCHHCCCCCCCCHHHHHCCCHHHHHEEEECCCCCCCCCCCHHEEEECCCCCCC
YSEIILKLLANPSIASKRWIYKQYDSQVQANTVFKPGESDAAVIRLREQNEKNKSKVFSG
HHHHHHHHHCCCCCCHHHHHHHHHCCCEEECEEECCCCCCEEEEEEECCCCCHHHHHHHC
VAASVDCNSRWVSLDPFRGTIAAVAESARNVSCVGAEPVAITNNLNFSSPETEIGYWQLS
CEEEECCCCCEEEECCCCHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCEEEEEEC
SSCNAISEACKALETPVTGGNVSLYNESKNRDNEITPINPTPVIGMVGKIDNVEKAISTE
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHH
WKNINDQIWLIGSHKSETTIAASSYLEYFHGEITGRPPKIDLQDEKFCQSFLRNAILNNF
HCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHHC
VVSSHDISDGGLAIALAECCILSAKGATIELEKDLNRDDNVLFSEGGSRIIFSIDKMKEK
EEECCCCCCCCHHHHHHHHHHEECCCCEEEECCCCCCCCCEEEECCCCEEEEEHHHHHHH
EWSNYLKKIQINSQSNVYVKKIGYVSSEILKIKIQDKNICDISVEELTEKFNNSISGYF
HHHHHHHEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA