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The map label for this gene is hisI

Identifier: 78358606

GI number: 78358606

Start: 3524546

End: 3524938

Strand: Reverse

Name: hisI

Synonym: Dde_3567

Alternate gene names: 78358606

Gene position: 3524938-3524546 (Counterclockwise)

Preceding gene: 78358607

Following gene: 78358605

Centisome position: 94.5

GC content: 55.47

Gene sequence:

>393_bases
ATGACCGCAGACCTTCCCGATTTTGTTCCCGACTTTGAAAAAACGGGCGGCCTTGTTCCCGCCATCGCACAGGACGCCGT
AAGCGGCGAAGTGCTGATGATGGCATGGATGAACGAGGAAGCATGGCACCGGACGCTTACCACCGGTGAAGCCCATTACT
TCAGCCGCAGCCGTGGTTCGCTGTGGCATAAAGGCGGAACTTCGGGACATACCCAGCATATCAGGGCCGTGCGTCTTGAC
TGCGACAGCGACACCATTCTGCTGCTCGTGGACCAGATAGGCGGCGCGGCCTGCCATAAAGGGTACAAAAGCTGTTTTTT
CCGTGAACTGAAGGATGGCGAGATTTCCGTATGCTCGCCCTTGGTGTTCGACCCTGAAGAGGTATATAAATAA

Upstream 100 bases:

>100_bases
TGAACCTGCTCCGGCCGCGTGGTGTACGCGGCCGCACCTTCTGTGTCCGGACACGCGCCGCGGAAATCCGCCATGCGCAT
AACCAAGAGGATCACATGGA

Downstream 100 bases:

>100_bases
TGTCTGCAGATACACATATCATCAAGCTCGGCCTGCCCAAAGGCTCTCTGGAACAGTCCACCATCAATCTGTTTGCCAAA
TCCGGCTGGAAGATACGCCA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MTADLPDFVPDFEKTGGLVPAIAQDAVSGEVLMMAWMNEEAWHRTLTTGEAHYFSRSRGSLWHKGGTSGHTQHIRAVRLD
CDSDTILLLVDQIGGAACHKGYKSCFFRELKDGEISVCSPLVFDPEEVYK

Sequences:

>Translated_130_residues
MTADLPDFVPDFEKTGGLVPAIAQDAVSGEVLMMAWMNEEAWHRTLTTGEAHYFSRSRGSLWHKGGTSGHTQHIRAVRLD
CDSDTILLLVDQIGGAACHKGYKSCFFRELKDGEISVCSPLVFDPEEVYK
>Mature_129_residues
TADLPDFVPDFEKTGGLVPAIAQDAVSGEVLMMAWMNEEAWHRTLTTGEAHYFSRSRGSLWHKGGTSGHTQHIRAVRLDC
DSDTILLLVDQIGGAACHKGYKSCFFRELKDGEISVCSPLVFDPEEVYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=96, Percent_Identity=52.0833333333333, Blast_Score=105, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_DESDG (Q30VD6)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_390055.1
- ProteinModelPortal:   Q30VD6
- SMR:   Q30VD6
- STRING:   Q30VD6
- GeneID:   3758547
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_3567
- NMPDR:   fig|207559.3.peg.2399
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- ProtClustDB:   PRK00051
- BioCyc:   DDES207559:DDE_3567-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14403; Mature: 14272

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADLPDFVPDFEKTGGLVPAIAQDAVSGEVLMMAWMNEEAWHRTLTTGEAHYFSRSRGS
CCCCCCCCCCCHHHCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHCCCCCHHHHCCCCCC
LWHKGGTSGHTQHIRAVRLDCDSDTILLLVDQIGGAACHKGYKSCFFRELKDGEISVCSP
EEECCCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCC
LVFDPEEVYK
CEECHHHHCC
>Mature Secondary Structure 
TADLPDFVPDFEKTGGLVPAIAQDAVSGEVLMMAWMNEEAWHRTLTTGEAHYFSRSRGS
CCCCCCCCCCHHHCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHCCCCCHHHHCCCCCC
LWHKGGTSGHTQHIRAVRLDCDSDTILLLVDQIGGAACHKGYKSCFFRELKDGEISVCSP
EEECCCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCC
LVFDPEEVYK
CEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA