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The map label for this gene is hisG

Identifier: 78358605

GI number: 78358605

Start: 3523662

End: 3524546

Strand: Reverse

Name: hisG

Synonym: Dde_3566

Alternate gene names: 78358605

Gene position: 3524546-3523662 (Counterclockwise)

Preceding gene: 78358606

Following gene: 78358604

Centisome position: 94.49

GC content: 57.51

Gene sequence:

>885_bases
ATGTCTGCAGATACACATATCATCAAGCTCGGCCTGCCCAAAGGCTCTCTGGAACAGTCCACCATCAATCTGTTTGCCAA
ATCCGGCTGGAAGATACGCCAGCATCACAGAAACTACTTTCCCGAAATCAACGACCCCGAGATCACGGCGCGTCTGTGCC
GTGTGCAGGAGATTCCCGGATATATCGAGGAAGGCATTCTTGACGTGGGGCTGACCGGCAAGGACTGGCTGCTGGAACAG
GGCTCGGACGTCGTGGTGGTTTCGGATCTTGTCTACTCTAAAACGTCCAACCGCCCCGCAAGCTGGGTGCTGGCCGTGGC
AGGAGATGCTCCGTACCAGCGCCCCGAGGATCTGGCAGGCAAACGTATTGCCACCGAACTGCTGGGCGTGACCAGACGCT
ATTTTGAAGATGCGGGTATCCCCGTCAATGTGTTTTATTCATGGGGAGCCACAGAGGCCAAGGTTGTCGAAGGGCTTGCC
GACGCCATTGTGGAGGTGACCGAGACAGGCACCACCATAAAAGCGCACGGGTTGCGGGTTATTGCCGAAGTGCTGCTGAC
GAACACTGTGCTTATTGCCAACCGGCAGGCATGGGAAGACCCGGCCAAGCGGCAGAAAATCGAACAGCTGGACCTGCTGC
TGCAGGGCGCATTGCGGGCCGAATCGCTGGTGGGGCTTAAGATGAACGTGCCCACGGGCAAACTTGATGCAGTGCTGGAC
AAGCTGCCCAGCCTCAATTCACCTACGGTGGCCAGCCTGCGCGACGGCAAATGGGTGGCGGTTGAAATCGTGGTGGATGA
AGGCGTGGTGCGCGACCTGATTCCCGAGCTGAAAGACGCTGGGGCAGAAGGCATCATCGAATACGCCCTGAATAAAGTCA
TCTGA

Upstream 100 bases:

>100_bases
GCCATAAAGGGTACAAAAGCTGTTTTTTCCGTGAACTGAAGGATGGCGAGATTTCCGTATGCTCGCCCTTGGTGTTCGAC
CCTGAAGAGGTATATAAATA

Downstream 100 bases:

>100_bases
CGCATGGCGCAGCCGTGCCTGCGGCGTTTGCGGCCTTCCGGCCGGAGCCGCAGTTCTTTGCTATATGCCGGAGGCTGCCC
CATGTCACAGGGGCAGCCTT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSADTHIIKLGLPKGSLEQSTINLFAKSGWKIRQHHRNYFPEINDPEITARLCRVQEIPGYIEEGILDVGLTGKDWLLEQ
GSDVVVVSDLVYSKTSNRPASWVLAVAGDAPYQRPEDLAGKRIATELLGVTRRYFEDAGIPVNVFYSWGATEAKVVEGLA
DAIVEVTETGTTIKAHGLRVIAEVLLTNTVLIANRQAWEDPAKRQKIEQLDLLLQGALRAESLVGLKMNVPTGKLDAVLD
KLPSLNSPTVASLRDGKWVAVEIVVDEGVVRDLIPELKDAGAEGIIEYALNKVI

Sequences:

>Translated_294_residues
MSADTHIIKLGLPKGSLEQSTINLFAKSGWKIRQHHRNYFPEINDPEITARLCRVQEIPGYIEEGILDVGLTGKDWLLEQ
GSDVVVVSDLVYSKTSNRPASWVLAVAGDAPYQRPEDLAGKRIATELLGVTRRYFEDAGIPVNVFYSWGATEAKVVEGLA
DAIVEVTETGTTIKAHGLRVIAEVLLTNTVLIANRQAWEDPAKRQKIEQLDLLLQGALRAESLVGLKMNVPTGKLDAVLD
KLPSLNSPTVASLRDGKWVAVEIVVDEGVVRDLIPELKDAGAEGIIEYALNKVI
>Mature_293_residues
SADTHIIKLGLPKGSLEQSTINLFAKSGWKIRQHHRNYFPEINDPEITARLCRVQEIPGYIEEGILDVGLTGKDWLLEQG
SDVVVVSDLVYSKTSNRPASWVLAVAGDAPYQRPEDLAGKRIATELLGVTRRYFEDAGIPVNVFYSWGATEAKVVEGLAD
AIVEVTETGTTIKAHGLRVIAEVLLTNTVLIANRQAWEDPAKRQKIEQLDLLLQGALRAESLVGLKMNVPTGKLDAVLDK
LPSLNSPTVASLRDGKWVAVEIVVDEGVVRDLIPELKDAGAEGIIEYALNKVI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=300, Percent_Identity=28.6666666666667, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320896, Length=246, Percent_Identity=30.4878048780488, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32166; Mature: 32035

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADTHIIKLGLPKGSLEQSTINLFAKSGWKIRQHHRNYFPEINDPEITARLCRVQEIPG
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
YIEEGILDVGLTGKDWLLEQGSDVVVVSDLVYSKTSNRPASWVLAVAGDAPYQRPEDLAG
HHHCCCEECCCCCCHHHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHH
KRIATELLGVTRRYFEDAGIPVNVFYSWGATEAKVVEGLADAIVEVTETGTTIKAHGLRV
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHH
IAEVLLTNTVLIANRQAWEDPAKRQKIEQLDLLLQGALRAESLVGLKMNVPTGKLDAVLD
HHHHHHHCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHH
KLPSLNSPTVASLRDGKWVAVEIVVDEGVVRDLIPELKDAGAEGIIEYALNKVI
HCCCCCCCCEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SADTHIIKLGLPKGSLEQSTINLFAKSGWKIRQHHRNYFPEINDPEITARLCRVQEIPG
CCCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
YIEEGILDVGLTGKDWLLEQGSDVVVVSDLVYSKTSNRPASWVLAVAGDAPYQRPEDLAG
HHHCCCEECCCCCCHHHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHH
KRIATELLGVTRRYFEDAGIPVNVFYSWGATEAKVVEGLADAIVEVTETGTTIKAHGLRV
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHH
IAEVLLTNTVLIANRQAWEDPAKRQKIEQLDLLLQGALRAESLVGLKMNVPTGKLDAVLD
HHHHHHHCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHH
KLPSLNSPTVASLRDGKWVAVEIVVDEGVVRDLIPELKDAGAEGIIEYALNKVI
HCCCCCCCCEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA