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The map label for this gene is trpE [H]

Identifier: 78358523

GI number: 78358523

Start: 3444019

End: 3445452

Strand: Reverse

Name: trpE [H]

Synonym: Dde_3484

Alternate gene names: 78358523

Gene position: 3445452-3444019 (Counterclockwise)

Preceding gene: 78358524

Following gene: 78358522

Centisome position: 92.37

GC content: 61.44

Gene sequence:

>1434_bases
ATGAACGTGAATCTCAGGCAATCGGCCCGCTGGATAGCCGCCGACGTGCAGACCCCCATCAGCCTTTTTCTGGGGCTGGT
GGGCAACGGGCAGGGCATTCTGCTGGAAAGTGCCGAGGTGGACGGGCGCTGGGGCCGTTACAGTGTCATCGGTTTCAACT
TTCTGCTGCGGCTCGGGTGCAGGGACGGCAAGCTGACAGTGGCTTCGCGCGATGCCCGTCTTGACTGCCTGAAAGAGCTG
GAAGGCATGGATTTTACGGATGGTGTGCGTGCCGTGCAGGCCGCCGTCGACATTACACCGGCAAGCGGATTTGAAGACCT
GCCGCCCATTACCCGCGGGCTGTACGGATACTTCGGGTACGGGGTGGCAGGCATGTTCGAACCGCATTTGCAGCGGGTTC
TGCCGGTGCAGAGCGCGGAAGCATGTCTGGTGCTGCCCGGCACCGTGGTGCTGGTGGACCACCTGTACAACAGGTTGTGC
CTGCTGAATCTGGCAGAAGGGTTTGTCATCCGCATGGACAGGGATGCCGTGGACAGAAAACCGGAGAATCCCGATGTGGG
TCCCGTTGTCATGGTGCCGGACAAGGCGACGTTCATCCGCAATGTGGAGCGGGTGAAGGAGCTCATACGGCAGGGCGAGG
CCATTCAGGTGGTGCTTTCCACGCGTTTTCAGGCTTCGTTCAAGGGCGATCCTTTTGTGCTGTACCGCCGGCTGCGCCAG
ATCAATCCTTCTCCGTACATGTTTTTCATGCGTCTGCCCGGCGTCAGTGTGCTGGGGTCGTCTCCGGAGGTGCTGGTCCG
CTGCAGGGGCGGCGAAGTGCAGGTCTGCCCCATAGCCGGTACCAGACCGCGGGGCAGCGATGAGGCGGAAGACATACGGC
TGGCCGAAGAGCTGCGCAACGACTCCAAGGAGCAGGCGGAGCATGTGATGCTGGTCGATCTGGGACGTAATGACCTGGGC
CGCATTGCAGAGGCAGGCACCGTAAGTGTTGAAAAGTACATGCAGGTCGAACGGTTTTCCCACGTCATGCACCTTACTTC
CTATGTCAGGGCGCGGCTGGCCGCAGGCAGGGACGCTCTGGATGTGCTGGCGGCCACGTTTCCGGCGGGAACGGTGAGCG
GTGCGCCCAAGGTGCGTGCCATGGAGATCATAGCGGACATGGAAGGGCTGGCCCGCGGTCCTTACGCCGGTGCCATAGGC
TGGCTGGGACTGGACAGCGGCAGTGTGGACATGGACACGGGCATTCTCATCCGTTCCATGTGGGTGCGCGACGGCATGGT
CAGCTGGCAGGCGGGAGCAGGCATCGTCTACGACTCGGTGCCCGAAAAAGAATGGGAAGAGTGCTGCAACAAGGCCAGAG
TGGTGCGTTCGGCCATCACGGGTACGCATGGCGGCGGATCAACGGGAGACTGCGATGTTTTTGCTTATCGATAA

Upstream 100 bases:

>100_bases
CGATATGTGCAACAGTTTGGTTGATACCAAGGCCGCATCCTCCCCGGATGCGGCCTTTTTTGTTTTTACCGCCGGAACCA
CCGCAAAGGAGCACAAGACA

Downstream 100 bases:

>100_bases
CTACGATTCGTTCACCTTTAATCTGGTGCAGGCCTTCAGCAAAGGCGGGCTTACTCCGCAGGTGCGCAAAAATGACGACC
CTGAACTGCCCGCGCTGGCA

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNVNLRQSARWIAADVQTPISLFLGLVGNGQGILLESAEVDGRWGRYSVIGFNFLLRLGCRDGKLTVASRDARLDCLKEL
EGMDFTDGVRAVQAAVDITPASGFEDLPPITRGLYGYFGYGVAGMFEPHLQRVLPVQSAEACLVLPGTVVLVDHLYNRLC
LLNLAEGFVIRMDRDAVDRKPENPDVGPVVMVPDKATFIRNVERVKELIRQGEAIQVVLSTRFQASFKGDPFVLYRRLRQ
INPSPYMFFMRLPGVSVLGSSPEVLVRCRGGEVQVCPIAGTRPRGSDEAEDIRLAEELRNDSKEQAEHVMLVDLGRNDLG
RIAEAGTVSVEKYMQVERFSHVMHLTSYVRARLAAGRDALDVLAATFPAGTVSGAPKVRAMEIIADMEGLARGPYAGAIG
WLGLDSGSVDMDTGILIRSMWVRDGMVSWQAGAGIVYDSVPEKEWEECCNKARVVRSAITGTHGGGSTGDCDVFAYR

Sequences:

>Translated_477_residues
MNVNLRQSARWIAADVQTPISLFLGLVGNGQGILLESAEVDGRWGRYSVIGFNFLLRLGCRDGKLTVASRDARLDCLKEL
EGMDFTDGVRAVQAAVDITPASGFEDLPPITRGLYGYFGYGVAGMFEPHLQRVLPVQSAEACLVLPGTVVLVDHLYNRLC
LLNLAEGFVIRMDRDAVDRKPENPDVGPVVMVPDKATFIRNVERVKELIRQGEAIQVVLSTRFQASFKGDPFVLYRRLRQ
INPSPYMFFMRLPGVSVLGSSPEVLVRCRGGEVQVCPIAGTRPRGSDEAEDIRLAEELRNDSKEQAEHVMLVDLGRNDLG
RIAEAGTVSVEKYMQVERFSHVMHLTSYVRARLAAGRDALDVLAATFPAGTVSGAPKVRAMEIIADMEGLARGPYAGAIG
WLGLDSGSVDMDTGILIRSMWVRDGMVSWQAGAGIVYDSVPEKEWEECCNKARVVRSAITGTHGGGSTGDCDVFAYR
>Mature_477_residues
MNVNLRQSARWIAADVQTPISLFLGLVGNGQGILLESAEVDGRWGRYSVIGFNFLLRLGCRDGKLTVASRDARLDCLKEL
EGMDFTDGVRAVQAAVDITPASGFEDLPPITRGLYGYFGYGVAGMFEPHLQRVLPVQSAEACLVLPGTVVLVDHLYNRLC
LLNLAEGFVIRMDRDAVDRKPENPDVGPVVMVPDKATFIRNVERVKELIRQGEAIQVVLSTRFQASFKGDPFVLYRRLRQ
INPSPYMFFMRLPGVSVLGSSPEVLVRCRGGEVQVCPIAGTRPRGSDEAEDIRLAEELRNDSKEQAEHVMLVDLGRNDLG
RIAEAGTVSVEKYMQVERFSHVMHLTSYVRARLAAGRDALDVLAATFPAGTVSGAPKVRAMEIIADMEGLARGPYAGAIG
WLGLDSGSVDMDTGILIRSMWVRDGMVSWQAGAGIVYDSVPEKEWEECCNKARVVRSAITGTHGGGSTGDCDVFAYR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=377, Percent_Identity=38.7267904509284, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1788114, Length=432, Percent_Identity=34.4907407407407, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI87082077, Length=271, Percent_Identity=30.9963099630996, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786809, Length=260, Percent_Identity=28.4615384615385, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320935, Length=454, Percent_Identity=36.1233480176211, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6324361, Length=394, Percent_Identity=26.3959390862944, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 52185; Mature: 52185

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVNLRQSARWIAADVQTPISLFLGLVGNGQGILLESAEVDGRWGRYSVIGFNFLLRLGC
CCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEHHHHHHHCCC
RDGKLTVASRDARLDCLKELEGMDFTDGVRAVQAAVDITPASGFEDLPPITRGLYGYFGY
CCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
GVAGMFEPHLQRVLPVQSAEACLVLPGTVVLVDHLYNRLCLLNLAEGFVIRMDRDAVDRK
CHHHHCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCC
PENPDVGPVVMVPDKATFIRNVERVKELIRQGEAIQVVLSTRFQASFKGDPFVLYRRLRQ
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
INPSPYMFFMRLPGVSVLGSSPEVLVRCRGGEVQVCPIAGTRPRGSDEAEDIRLAEELRN
CCCCCEEEEEECCCCEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHC
DSKEQAEHVMLVDLGRNDLGRIAEAGTVSVEKYMQVERFSHVMHLTSYVRARLAAGRDAL
CCHHHHCEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DVLAATFPAGTVSGAPKVRAMEIIADMEGLARGPYAGAIGWLGLDSGSVDMDTGILIRSM
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHH
WVRDGMVSWQAGAGIVYDSVPEKEWEECCNKARVVRSAITGTHGGGSTGDCDVFAYR
HHHCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNVNLRQSARWIAADVQTPISLFLGLVGNGQGILLESAEVDGRWGRYSVIGFNFLLRLGC
CCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEHHHHHHHCCC
RDGKLTVASRDARLDCLKELEGMDFTDGVRAVQAAVDITPASGFEDLPPITRGLYGYFGY
CCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
GVAGMFEPHLQRVLPVQSAEACLVLPGTVVLVDHLYNRLCLLNLAEGFVIRMDRDAVDRK
CHHHHCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCC
PENPDVGPVVMVPDKATFIRNVERVKELIRQGEAIQVVLSTRFQASFKGDPFVLYRRLRQ
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
INPSPYMFFMRLPGVSVLGSSPEVLVRCRGGEVQVCPIAGTRPRGSDEAEDIRLAEELRN
CCCCCEEEEEECCCCEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHC
DSKEQAEHVMLVDLGRNDLGRIAEAGTVSVEKYMQVERFSHVMHLTSYVRARLAAGRDAL
CCHHHHCEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DVLAATFPAGTVSGAPKVRAMEIIADMEGLARGPYAGAIGWLGLDSGSVDMDTGILIRSM
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHH
WVRDGMVSWQAGAGIVYDSVPEKEWEECCNKARVVRSAITGTHGGGSTGDCDVFAYR
HHHCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]