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The map label for this gene is fabF [H]

Identifier: 78357702

GI number: 78357702

Start: 2673049

End: 2674377

Strand: Direct

Name: fabF [H]

Synonym: Dde_2660

Alternate gene names: 78357702

Gene position: 2673049-2674377 (Clockwise)

Preceding gene: 78357701

Following gene: 78357703

Centisome position: 71.66

GC content: 65.24

Gene sequence:

>1329_bases
ATGAAAAGGCTCCGAGCCATGCAGGCTGAACGCAGAGTGGTCATCACCGGCGCCGGTGCCGTCACCCCGCTGGGGCATAC
GCCACAGGACATCCGGCAGTCGGTGCTGACCGGCCGCACCGTATTTGAACCTACTTCCGTGCCGGCGGGGTATGCACAGG
CACCGGCGCAGTTCGATGCCGACGATGCACTGCGGGGCTGGCGGCACCGGCGCTATCTTAACCGCGGTGCGGCCATGGCC
GTGCATGCCGCACGTCAGGCTGCCGGAGCTGCCGGTTTTGCTGCGGGTCTGCCCGGATACTGCGGAATATTCGCCGGAAG
CGGTCCGCATCTGGATATGGACAGCGACTACGCACAGCCGCAGCACCTTCCGCAACGGCATGATACGCTTTGTGCCTTAT
GGATGCTGCGCTATCTGCCCAACACGGCAGCTTCGGCCATCAGCCAGTTGCTGGGCGCCCGCGGCGAAAGTCTGGTGACC
GGTACTGCCTGCGCGGCCTCGCTGCAGGCAGTGGGAGAGGCCTTCCGCCGCATCCGCCACGGGGTACTGCCTGTGGCGCT
GGCCGGCGGAGGCGATTCGCGCCTGTCATACGGCGGCCTTTTGGCCTATGCCAAGGCGGGCGCACTGGCTCCGTGTTCTG
AAGACACTCATGCCGCAGCAGCAGCGGCATGCAGGCCCTTTGACACCGGTCGGCAGGGATTTGCAGCAGGTGAAGGAGCC
GCTTTTTTTGTACTGGAATCGCTGGACCATGCGCAAAAACGCGGCGCTGTTCCGCTGGCTGAAGTATGCGGATACGGCTG
CAGCATGGACGGCCACGCCATGACCGCACCGCACCCGCAGGGCATGCACGCGGAACAGGCTGTCAGAACCGCTCTGCATG
AAGCAGGGGCCGGACCGGCCGATGTGACCGCCGTCTGTGCACACGGTACGGGTACGCGGCGCAACGACACCGCCGAATCA
GTCATGCTCACGCGGCTTTTTGCCCCGACCGGACACCGGCCGCCGGTTCTTGCCCTCAAATCATGGACAGGACACTGCGC
CTCTGCCTGCGGTGCCGTGGAACTGGCCGTACTGCTGGCCTGTGCCCGGCACGGTTTTCTGCCCCCCGTGCGCAACCTGC
AGACTCCGCTGTGCGACAGTCTCTCGTTTGTCCGCCGCATTCACCCGTGCACCGCTGCAGAGCTGTACGCTGCCGGACGT
CCGGAAAAGCTTTCCGCCCTGACGCTTCTGCAGAGCTTCGGGTTCGGCGGCCAGAACGCCGCGCTGGCGGTACGTCCCTT
CCGCGCATCAACCGCCGCGGCAATACAGGATGACAATATACCGGCATGA

Upstream 100 bases:

>100_bases
GACCGCGTGGCCTGCATACTCCGCACACTGGATGATGGGCCCGTGCTGAGCGTACAGGATATTGCGGATTACGTGCTGCA
CGCCCTGCGCGCCGGACAGC

Downstream 100 bases:

>100_bases
AACATAAAAACACTATCACGCTGCGCTGCAACGCCGCTCCGGCGCCGGAAACGCTCCATACGCCGGCCACGGCCCTGTTC
GTTGTACCCGCCGCGGTAAG

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKRLRAMQAERRVVITGAGAVTPLGHTPQDIRQSVLTGRTVFEPTSVPAGYAQAPAQFDADDALRGWRHRRYLNRGAAMA
VHAARQAAGAAGFAAGLPGYCGIFAGSGPHLDMDSDYAQPQHLPQRHDTLCALWMLRYLPNTAASAISQLLGARGESLVT
GTACAASLQAVGEAFRRIRHGVLPVALAGGGDSRLSYGGLLAYAKAGALAPCSEDTHAAAAAACRPFDTGRQGFAAGEGA
AFFVLESLDHAQKRGAVPLAEVCGYGCSMDGHAMTAPHPQGMHAEQAVRTALHEAGAGPADVTAVCAHGTGTRRNDTAES
VMLTRLFAPTGHRPPVLALKSWTGHCASACGAVELAVLLACARHGFLPPVRNLQTPLCDSLSFVRRIHPCTAAELYAAGR
PEKLSALTLLQSFGFGGQNAALAVRPFRASTAAAIQDDNIPA

Sequences:

>Translated_442_residues
MKRLRAMQAERRVVITGAGAVTPLGHTPQDIRQSVLTGRTVFEPTSVPAGYAQAPAQFDADDALRGWRHRRYLNRGAAMA
VHAARQAAGAAGFAAGLPGYCGIFAGSGPHLDMDSDYAQPQHLPQRHDTLCALWMLRYLPNTAASAISQLLGARGESLVT
GTACAASLQAVGEAFRRIRHGVLPVALAGGGDSRLSYGGLLAYAKAGALAPCSEDTHAAAAAACRPFDTGRQGFAAGEGA
AFFVLESLDHAQKRGAVPLAEVCGYGCSMDGHAMTAPHPQGMHAEQAVRTALHEAGAGPADVTAVCAHGTGTRRNDTAES
VMLTRLFAPTGHRPPVLALKSWTGHCASACGAVELAVLLACARHGFLPPVRNLQTPLCDSLSFVRRIHPCTAAELYAAGR
PEKLSALTLLQSFGFGGQNAALAVRPFRASTAAAIQDDNIPA
>Mature_442_residues
MKRLRAMQAERRVVITGAGAVTPLGHTPQDIRQSVLTGRTVFEPTSVPAGYAQAPAQFDADDALRGWRHRRYLNRGAAMA
VHAARQAAGAAGFAAGLPGYCGIFAGSGPHLDMDSDYAQPQHLPQRHDTLCALWMLRYLPNTAASAISQLLGARGESLVT
GTACAASLQAVGEAFRRIRHGVLPVALAGGGDSRLSYGGLLAYAKAGALAPCSEDTHAAAAAACRPFDTGRQGFAAGEGA
AFFVLESLDHAQKRGAVPLAEVCGYGCSMDGHAMTAPHPQGMHAEQAVRTALHEAGAGPADVTAVCAHGTGTRRNDTAES
VMLTRLFAPTGHRPPVLALKSWTGHCASACGAVELAVLLACARHGFLPPVRNLQTPLCDSLSFVRRIHPCTAAELYAAGR
PEKLSALTLLQSFGFGGQNAALAVRPFRASTAAAIQDDNIPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=431, Percent_Identity=32.9466357308585, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI41872631, Length=286, Percent_Identity=27.972027972028, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI223972627, Length=196, Percent_Identity=31.1224489795918, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787337, Length=430, Percent_Identity=29.5348837209302, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI1788663, Length=431, Percent_Identity=27.1461716937355, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=28.7081339712919, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71983535, Length=275, Percent_Identity=32.7272727272727, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI212642053, Length=306, Percent_Identity=26.797385620915, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=349, Percent_Identity=25.5014326647564, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=463, Percent_Identity=28.7257019438445, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24644341, Length=440, Percent_Identity=32.5, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19920632, Length=284, Percent_Identity=27.112676056338, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=284, Percent_Identity=27.112676056338, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581345, Length=285, Percent_Identity=27.0175438596491, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45988; Mature: 45988

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLRAMQAERRVVITGAGAVTPLGHTPQDIRQSVLTGRTVFEPTSVPAGYAQAPAQFDA
CCHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCH
DDALRGWRHRRYLNRGAAMAVHAARQAAGAAGFAAGLPGYCGIFAGSGPHLDMDSDYAQP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCHHEEECCCCCCCCCCCCCCCC
QHLPQRHDTLCALWMLRYLPNTAASAISQLLGARGESLVTGTACAASLQAVGEAFRRIRH
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
GVLPVALAGGGDSRLSYGGLLAYAKAGALAPCSEDTHAAAAAACRPFDTGRQGFAAGEGA
CCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
AFFVLESLDHAQKRGAVPLAEVCGYGCSMDGHAMTAPHPQGMHAEQAVRTALHEAGAGPA
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
DVTAVCAHGTGTRRNDTAESVMLTRLFAPTGHRPPVLALKSWTGHCASACGAVELAVLLA
CCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
CARHGFLPPVRNLQTPLCDSLSFVRRIHPCTAAELYAAGRPEKLSALTLLQSFGFGGQNA
HHHCCCCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
ALAVRPFRASTAAAIQDDNIPA
EEEEECCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MKRLRAMQAERRVVITGAGAVTPLGHTPQDIRQSVLTGRTVFEPTSVPAGYAQAPAQFDA
CCHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCH
DDALRGWRHRRYLNRGAAMAVHAARQAAGAAGFAAGLPGYCGIFAGSGPHLDMDSDYAQP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCCHHEEECCCCCCCCCCCCCCCC
QHLPQRHDTLCALWMLRYLPNTAASAISQLLGARGESLVTGTACAASLQAVGEAFRRIRH
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
GVLPVALAGGGDSRLSYGGLLAYAKAGALAPCSEDTHAAAAAACRPFDTGRQGFAAGEGA
CCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
AFFVLESLDHAQKRGAVPLAEVCGYGCSMDGHAMTAPHPQGMHAEQAVRTALHEAGAGPA
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
DVTAVCAHGTGTRRNDTAESVMLTRLFAPTGHRPPVLALKSWTGHCASACGAVELAVLLA
CCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
CARHGFLPPVRNLQTPLCDSLSFVRRIHPCTAAELYAAGRPEKLSALTLLQSFGFGGQNA
HHHCCCCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
ALAVRPFRASTAAAIQDDNIPA
EEEEECCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]