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The map label for this gene is bioA [H]

Identifier: 78357698

GI number: 78357698

Start: 2670067

End: 2671446

Strand: Direct

Name: bioA [H]

Synonym: Dde_2656

Alternate gene names: 78357698

Gene position: 2670067-2671446 (Clockwise)

Preceding gene: 78357697

Following gene: 78357699

Centisome position: 71.58

GC content: 62.97

Gene sequence:

>1380_bases
ATGAACGCACTTCAACCCGACACGGAACGGCTGCGCGCACTGGACACGGCCCATGTATGGCACCCCTTCACCCAGATGGC
GACGTGGCACGAAGACGCGCCGCTGATAATCGAAAAAGCCCGCGGCAACTGGCTGGTGGATACCGACGGCAACCGCTATC
TGGACGGTGTTTCTTCGCTGTGGACCAACGTGCACGGCCACAGACACCCGCATATTGATGCGGCCATACGCGCCCAGCTG
GACAACGTGGCACATTCCACGCTGCTGGGCCTATCGAGCCGCCCTGCCATTGAGCTTGCGGCCATGCTGGCCCGGGTAGC
CCCGCAGGGACTGAACCGCGTCTTCTATTCCGACAGCGGCTCCACTGCGGTGGAAGTGGCGCTGAAGATAGCCTACCAGT
ACCAGAAGCAACGCGGCCCCGCCGGAGAAGGTCGCAGCAAGTTTTTATGCCTGCGGGGAGCGTACCACGGCGACACCGTG
GGGGCCGTTTCGCTGGGCGGCATAGACCTGTTTCATGCCGTGTACGGCGGGCTGCTGTTTAAAACCGTACGGGCCGAGGC
GCCGTACTGCTACCGGTGCCCCTTCGGCCGGCAGAAAGAATCATGCCGCCACGAGTGCTTCACCCATCTGGAAGAAACGG
CCACACGCCACGCGCCGGAACTGGCCGCCATGGTCATAGAGCCGCTGGTTCAGGGTGCCGCCGGTCAGATAACACACCCC
GACGGTTATCTGGCCCACGCCCGCGCCCTGTGCGACAGGCTCGGTATTCTGCTTATCGCCGACGAAGTGGCCGTGGGTTT
CGGCAAAACCGGAACCATGTTTGCCTGCGAACAGGAAAAAGTGACTCCCGACCTGCTGTGTCTGGCCAAAGGCATTTCCG
GCGGTTATCTGCCGCTGGCAGCCACCATGGTGACCGACGCCGTATACGAGGCTTTTCTGGGCGACCACGCGCAATGCCGC
ACGTTTTTCCACGGGCACACCTATACCGGTAATGCGCTGGCATGTGCCGCAGGCATAGCCAGCCTGCAGCTTTTCCGCAC
CGAAGGCACACTGGAGCGGCTGCAGCATATCATCACCATATACGATGCACTGCTGCGGCAGCTGGAAACACTGCCCCATG
TGGGCGATATCCGCCGCAGGGGCATCATGACCGGCATAGAGCTGGTGGAAGACCGCGCCACACGCCGTCCGTATCCTTTT
GCCCTGCGCACCGCGCACAAGGTGGTGCTGGCAGCACGCAGGAGAGGAGTTATCATCCGGCCGCTGGGCGACGTGCTGGT
GCTCATGCCGCCCCTGAGCATCACCGCGCAGGAGTGCGGCCTGCTGGTCGAAGCCACGGCGGAAGCCATACAGGAAGTGA
CCGGAGGCCCCCGTGTCTGA

Upstream 100 bases:

>100_bases
TCAGCGGCGCCAACGGGCTGATGGTGGGCAATTATCTGACAACCGCGGGCCGCAGCACCGCTGACGACTACACCATGCTG
CGCCATATGGGAGTACTCCG

Downstream 100 bases:

>100_bases
AAAAAATATGCCTGAAAAAACTGTGTCTGAGCGGGACGGGGAAAGTTCGGACGCCCCCCGTGATACCGCCATGTCCGGCG
CGCAAAAACACTCCGCAGAA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MNALQPDTERLRALDTAHVWHPFTQMATWHEDAPLIIEKARGNWLVDTDGNRYLDGVSSLWTNVHGHRHPHIDAAIRAQL
DNVAHSTLLGLSSRPAIELAAMLARVAPQGLNRVFYSDSGSTAVEVALKIAYQYQKQRGPAGEGRSKFLCLRGAYHGDTV
GAVSLGGIDLFHAVYGGLLFKTVRAEAPYCYRCPFGRQKESCRHECFTHLEETATRHAPELAAMVIEPLVQGAAGQITHP
DGYLAHARALCDRLGILLIADEVAVGFGKTGTMFACEQEKVTPDLLCLAKGISGGYLPLAATMVTDAVYEAFLGDHAQCR
TFFHGHTYTGNALACAAGIASLQLFRTEGTLERLQHIITIYDALLRQLETLPHVGDIRRRGIMTGIELVEDRATRRPYPF
ALRTAHKVVLAARRRGVIIRPLGDVLVLMPPLSITAQECGLLVEATAEAIQEVTGGPRV

Sequences:

>Translated_459_residues
MNALQPDTERLRALDTAHVWHPFTQMATWHEDAPLIIEKARGNWLVDTDGNRYLDGVSSLWTNVHGHRHPHIDAAIRAQL
DNVAHSTLLGLSSRPAIELAAMLARVAPQGLNRVFYSDSGSTAVEVALKIAYQYQKQRGPAGEGRSKFLCLRGAYHGDTV
GAVSLGGIDLFHAVYGGLLFKTVRAEAPYCYRCPFGRQKESCRHECFTHLEETATRHAPELAAMVIEPLVQGAAGQITHP
DGYLAHARALCDRLGILLIADEVAVGFGKTGTMFACEQEKVTPDLLCLAKGISGGYLPLAATMVTDAVYEAFLGDHAQCR
TFFHGHTYTGNALACAAGIASLQLFRTEGTLERLQHIITIYDALLRQLETLPHVGDIRRRGIMTGIELVEDRATRRPYPF
ALRTAHKVVLAARRRGVIIRPLGDVLVLMPPLSITAQECGLLVEATAEAIQEVTGGPRV
>Mature_459_residues
MNALQPDTERLRALDTAHVWHPFTQMATWHEDAPLIIEKARGNWLVDTDGNRYLDGVSSLWTNVHGHRHPHIDAAIRAQL
DNVAHSTLLGLSSRPAIELAAMLARVAPQGLNRVFYSDSGSTAVEVALKIAYQYQKQRGPAGEGRSKFLCLRGAYHGDTV
GAVSLGGIDLFHAVYGGLLFKTVRAEAPYCYRCPFGRQKESCRHECFTHLEETATRHAPELAAMVIEPLVQGAAGQITHP
DGYLAHARALCDRLGILLIADEVAVGFGKTGTMFACEQEKVTPDLLCLAKGISGGYLPLAATMVTDAVYEAFLGDHAQCR
TFFHGHTYTGNALACAAGIASLQLFRTEGTLERLQHIITIYDALLRQLETLPHVGDIRRRGIMTGIELVEDRATRRPYPF
ALRTAHKVVLAARRRGVIIRPLGDVLVLMPPLSITAQECGLLVEATAEAIQEVTGGPRV

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=457, Percent_Identity=28.8840262582057, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI4557809, Length=443, Percent_Identity=26.86230248307, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=28.0742459396752, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=27.2935779816514, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI226442709, Length=404, Percent_Identity=27.970297029703, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=27.1428571428571, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI284507298, Length=336, Percent_Identity=27.6785714285714, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI188536080, Length=433, Percent_Identity=22.6327944572748, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679950, Length=433, Percent_Identity=22.6327944572748, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679946, Length=433, Percent_Identity=22.6327944572748, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786991, Length=449, Percent_Identity=38.5300668151448, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI145693181, Length=417, Percent_Identity=33.3333333333333, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789016, Length=416, Percent_Identity=34.375, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788044, Length=412, Percent_Identity=28.8834951456311, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789759, Length=425, Percent_Identity=28.4705882352941, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787560, Length=409, Percent_Identity=28.6063569682152, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786349, Length=358, Percent_Identity=29.0502793296089, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=456, Percent_Identity=29.6052631578947, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144271, Length=427, Percent_Identity=25.9953161592506, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=451, Percent_Identity=27.0509977827051, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=234, Percent_Identity=31.6239316239316, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=319, Percent_Identity=26.0188087774295, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=480, Percent_Identity=30.625, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6323470, Length=443, Percent_Identity=27.765237020316, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324432, Length=448, Percent_Identity=25.6696428571429, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321456, Length=309, Percent_Identity=27.1844660194175, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI161085790, Length=460, Percent_Identity=30.4347826086957, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28574759, Length=453, Percent_Identity=30.9050772626932, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21357415, Length=430, Percent_Identity=28.6046511627907, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356575, Length=438, Percent_Identity=28.5388127853881, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281366494, Length=319, Percent_Identity=26.9592476489028, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667139, Length=319, Percent_Identity=26.9592476489028, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667143, Length=319, Percent_Identity=26.9592476489028, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50130; Mature: 50130

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALQPDTERLRALDTAHVWHPFTQMATWHEDAPLIIEKARGNWLVDTDGNRYLDGVSSL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCCCEEEECCCCHHHHHHHHH
WTNVHGHRHPHIDAAIRAQLDNVAHSTLLGLSSRPAIELAAMLARVAPQGLNRVFYSDSG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCEEEECCCC
STAVEVALKIAYQYQKQRGPAGEGRSKFLCLRGAYHGDTVGAVSLGGIDLFHAVYGGLLF
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHH
KTVRAEAPYCYRCPFGRQKESCRHECFTHLEETATRHAPELAAMVIEPLVQGAAGQITHP
HHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
DGYLAHARALCDRLGILLIADEVAVGFGKTGTMFACEQEKVTPDLLCLAKGISGGYLPLA
CCHHHHHHHHHHHCCEEEEECHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHH
ATMVTDAVYEAFLGDHAQCRTFFHGHTYTGNALACAAGIASLQLFRTEGTLERLQHIITI
HHHHHHHHHHHHHCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YDALLRQLETLPHVGDIRRRGIMTGIELVEDRATRRPYPFALRTAHKVVLAARRRGVIIR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEE
PLGDVLVLMPPLSITAQECGLLVEATAEAIQEVTGGPRV
ECCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNALQPDTERLRALDTAHVWHPFTQMATWHEDAPLIIEKARGNWLVDTDGNRYLDGVSSL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCCCEEEECCCCHHHHHHHHH
WTNVHGHRHPHIDAAIRAQLDNVAHSTLLGLSSRPAIELAAMLARVAPQGLNRVFYSDSG
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCEEEECCCC
STAVEVALKIAYQYQKQRGPAGEGRSKFLCLRGAYHGDTVGAVSLGGIDLFHAVYGGLLF
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHH
KTVRAEAPYCYRCPFGRQKESCRHECFTHLEETATRHAPELAAMVIEPLVQGAAGQITHP
HHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
DGYLAHARALCDRLGILLIADEVAVGFGKTGTMFACEQEKVTPDLLCLAKGISGGYLPLA
CCHHHHHHHHHHHCCEEEEECHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHH
ATMVTDAVYEAFLGDHAQCRTFFHGHTYTGNALACAAGIASLQLFRTEGTLERLQHIITI
HHHHHHHHHHHHHCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YDALLRQLETLPHVGDIRRRGIMTGIELVEDRATRRPYPFALRTAHKVVLAARRRGVIIR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEE
PLGDVLVLMPPLSITAQECGLLVEATAEAIQEVTGGPRV
ECCCEEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]