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The map label for this gene is msrAB [H]

Identifier: 78357525

GI number: 78357525

Start: 2502566

End: 2503207

Strand: Direct

Name: msrAB [H]

Synonym: Dde_2482

Alternate gene names: 78357525

Gene position: 2502566-2503207 (Clockwise)

Preceding gene: 78357524

Following gene: 78357526

Centisome position: 67.09

GC content: 58.72

Gene sequence:

>642_bases
ATGCTCCGTCATTTCCCGGGAATAATACTGGCTGCCGCACTCATCATCATACCGCTCACGACGCTGTACGCCACAGCAAA
ACTGCCGCCCGGCAAGCTGCCGGACTCTCCGCCGGAGGGGCTGGCGTATGCCACATTTGCCGGCGGATGCTTCTGGTGCA
TGGAACCGCCCTTTGACCGGACTCCCGGAGTGCTTGAAACAATTTCAGGCTATACCGGCGGCCACACGGAACATCCGAGC
TATGAACAGGTTTCCGCAGGCGGCACAGGACACTACGAAGCGCTGCGTGTGGTCTTTGATCCGCGTCAGGTCAGCTATGA
CACACTGCTGACCATTTTCTGGAGTAACATAGACCCTTATGATGCATCGGGCCAGTTCTGCGACAGAGGCGATCAATACC
GGTCCGCCGTTTTCTGGCACGACGACGGGCAGAAAGAAGCAGCCCTGCGTTCCGTGGCGCACGGTCTGCAGGACGGCAGC
CTTGACAAAGCCCCCGCCACTGAAATCCTGCCCGCACAGGATTTCTGGCAGGCCGAAGACTACCATCAGGACTACTACCG
CAAGAACCCCGTGCGTTATAAGTTCTACCGCTTCAGCTGCGGACGCGACCAGCGGCTGGAAGAACTGCACGACAAACGCT
GA

Upstream 100 bases:

>100_bases
CTGCCTGTGCAGGCGTGCAAAAAACAACCTCGTGTGGTACATACGGGTACCCTCTGACCACACAAGGCAGAATTTTGCCG
CCGCAACCGCAGGAGGACTC

Downstream 100 bases:

>100_bases
GCGACAAAAAAGCAGGCCGGAGAGATATGCCTCCGGCCTGCGTCTGTTACGATGGCAGCTGCGGCGATTCCGCACGCAGC
GTGCAAAACGTCGGCAACTG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MLRHFPGIILAAALIIIPLTTLYATAKLPPGKLPDSPPEGLAYATFAGGCFWCMEPPFDRTPGVLETISGYTGGHTEHPS
YEQVSAGGTGHYEALRVVFDPRQVSYDTLLTIFWSNIDPYDASGQFCDRGDQYRSAVFWHDDGQKEAALRSVAHGLQDGS
LDKAPATEILPAQDFWQAEDYHQDYYRKNPVRYKFYRFSCGRDQRLEELHDKR

Sequences:

>Translated_213_residues
MLRHFPGIILAAALIIIPLTTLYATAKLPPGKLPDSPPEGLAYATFAGGCFWCMEPPFDRTPGVLETISGYTGGHTEHPS
YEQVSAGGTGHYEALRVVFDPRQVSYDTLLTIFWSNIDPYDASGQFCDRGDQYRSAVFWHDDGQKEAALRSVAHGLQDGS
LDKAPATEILPAQDFWQAEDYHQDYYRKNPVRYKFYRFSCGRDQRLEELHDKR
>Mature_213_residues
MLRHFPGIILAAALIIIPLTTLYATAKLPPGKLPDSPPEGLAYATFAGGCFWCMEPPFDRTPGVLETISGYTGGHTEHPS
YEQVSAGGTGHYEALRVVFDPRQVSYDTLLTIFWSNIDPYDASGQFCDRGDQYRSAVFWHDDGQKEAALRSVAHGLQDGS
LDKAPATEILPAQDFWQAEDYHQDYYRKNPVRYKFYRFSCGRDQRLEELHDKR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=164, Percent_Identity=42.0731707317073, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI208609995, Length=164, Percent_Identity=42.0731707317073, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=42.4778761061947, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1790665, Length=177, Percent_Identity=41.8079096045198, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=32.6530612244898, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=32.484076433121, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=36.1111111111111, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=35.036496350365, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 24040; Mature: 24040

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRHFPGIILAAALIIIPLTTLYATAKLPPGKLPDSPPEGLAYATFAGGCFWCMEPPFDR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCC
TPGVLETISGYTGGHTEHPSYEQVSAGGTGHYEALRVVFDPRQVSYDTLLTIFWSNIDPY
CCCHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHEEEEEECCCHHCHHHHHHHHHCCCCCC
DASGQFCDRGDQYRSAVFWHDDGQKEAALRSVAHGLQDGSLDKAPATEILPAQDFWQAED
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
YHQDYYRKNPVRYKFYRFSCGRDQRLEELHDKR
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure
MLRHFPGIILAAALIIIPLTTLYATAKLPPGKLPDSPPEGLAYATFAGGCFWCMEPPFDR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCC
TPGVLETISGYTGGHTEHPSYEQVSAGGTGHYEALRVVFDPRQVSYDTLLTIFWSNIDPY
CCCHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHEEEEEECCCHHCHHHHHHHHHCCCCCC
DASGQFCDRGDQYRSAVFWHDDGQKEAALRSVAHGLQDGSLDKAPATEILPAQDFWQAED
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
YHQDYYRKNPVRYKFYRFSCGRDQRLEELHDKR
HHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]