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The map label for this gene is nhaC [H]

Identifier: 78355508

GI number: 78355508

Start: 470937

End: 472388

Strand: Direct

Name: nhaC [H]

Synonym: Dde_0461

Alternate gene names: 78355508

Gene position: 470937-472388 (Clockwise)

Preceding gene: 78355504

Following gene: 78355509

Centisome position: 12.62

GC content: 61.71

Gene sequence:

>1452_bases
ATGAGCGGGTCTAACAACAGAAACACGCAGGACGCCGGTGCCGGTCCCAGACCGGGATTGCTCTGGGCCGTGCTGTGCTT
CACGCTGCCTGTGGGCGTCATCCTGTACGGAACCGTTTTTGTGGGAGTGCGCCCGCCCGTGCTGCCGTTGCTGGCCGCCG
TGGCGCTGGCCGGATTGATGTGCCTGCCTGTGGGCTACACATGGAAAGAGCTGCAGGAAGGCATGCTGGAGTCTCTGGGC
AGGGTGCAGCTTGCCGTGGCCATTCTGGTCATGGTGGGCATGACCATCAGCGCGTGGCTGGCATCGGGCACCATTCCGGC
CATCATCTACTGGGGGCTTAAACTTATCGCTCCGCAGTATTTTTTTGCATCGGCTTTTGTGCTGTGCGCCGTTGCTTCTG
TGGCCACAGGAACATCGTTCGGCACCATGGGCACCATCGGTGTCGCCCTGCTGGGCGTGGGCGGAGTGATGGGTTTTTCG
CCCGCCATGACCGTGGGGGCCATCGTTTCCGGAGCCTATTTCGGTGACAAAATGTCTCCGGTTTCCGACTCCACCAACAT
TACCGCCACCATCTGCGAAACTCCGCTTTTCACGCATATCAGTTCCATGATGTGGACCACCGTGCCCGCCGCGCTGGTGG
CCATGGCCGGCTTTATGCTGCTGGGGGCCACGCAGACGGCTGCCTCCGGCAGTCTGGAAAGCCTTTCCGGCATTCTGGCG
GGCCTTGAAAACGGCTTCAACCTGTCGCCGGTGGTATTCATTCCTCCGGTGCTCATGGTGATACTGGCTTACAGAAGATA
CCCCGTGCTGCCGGTCATGGGCGTATGTCTGCTGAGCGCGCTGCTCATCGCGCTGGCAGGCGGCGCCACGCTGGATGTGC
TGGCAAAGCAGCTGACCACCGGCTACAAGGCCGCCACGGAATCGGCACAGCTTAACAAGCTGCTTTCGCGCGGGGGGCTT
ATGTCTGTCATGCCCACCATTCTGCTGCTGACTTCGGGTATGGCTTTCGGCGGCATTCTGGAGCGCGCCCGCGTGCTGGA
AGTGCTTCTTGATGCCATGCTGCGCGGTTCCAGGTCGCCTGTGCGGCTTGTGGCGTCCACGCTGGGGTCCGCATATATCA
TACTGCTGGGCACCGGCAGCCAGATGCTGGCTGCCATTATTCCCGGCCGTGCCTTTCTGCATGCCTACGATGAAAACGAC
CTGCACCGCTCCGTGCTTTCGCGCACCTGCGAAGACGCCGGTACGCTTGGCTGCCCGCTGGTGCCGTGGAGCGTGCACGC
ATTTTATATAATGGGGGTGCTGGGTGTCAGCGCCTATGAATTTGCCCCGTACGCTTTGCTTAACTGGGGCGTTCCCGTGT
TCTCCATTCTGTGCGCCATGACCGGCATCGGCATGCGCAGGCGCGACGGTTCGCCCGTGCGCCGTGCACCCGCACAGGTG
GAAAACGCCTGA

Upstream 100 bases:

>100_bases
TCCGGCGCGCGGAAGCTGCCTGAAAGCGGCGGACCGGCCGCACGGACGCGTGCGGAGAACCGGTTGATGTTGCGCAACTT
TTACTACGCGAGGAGTGGAT

Downstream 100 bases:

>100_bases
CAAAACATGAAAAAACGGGAGACCGGTGTATAGTATGGCTTCAGAATCCATAAAGAACGTCATCTTCATCATGCTGGATA
CTCTGCAGTTCAACTATCTG

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSGSNNRNTQDAGAGPRPGLLWAVLCFTLPVGVILYGTVFVGVRPPVLPLLAAVALAGLMCLPVGYTWKELQEGMLESLG
RVQLAVAILVMVGMTISAWLASGTIPAIIYWGLKLIAPQYFFASAFVLCAVASVATGTSFGTMGTIGVALLGVGGVMGFS
PAMTVGAIVSGAYFGDKMSPVSDSTNITATICETPLFTHISSMMWTTVPAALVAMAGFMLLGATQTAASGSLESLSGILA
GLENGFNLSPVVFIPPVLMVILAYRRYPVLPVMGVCLLSALLIALAGGATLDVLAKQLTTGYKAATESAQLNKLLSRGGL
MSVMPTILLLTSGMAFGGILERARVLEVLLDAMLRGSRSPVRLVASTLGSAYIILLGTGSQMLAAIIPGRAFLHAYDEND
LHRSVLSRTCEDAGTLGCPLVPWSVHAFYIMGVLGVSAYEFAPYALLNWGVPVFSILCAMTGIGMRRRDGSPVRRAPAQV
ENA

Sequences:

>Translated_483_residues
MSGSNNRNTQDAGAGPRPGLLWAVLCFTLPVGVILYGTVFVGVRPPVLPLLAAVALAGLMCLPVGYTWKELQEGMLESLG
RVQLAVAILVMVGMTISAWLASGTIPAIIYWGLKLIAPQYFFASAFVLCAVASVATGTSFGTMGTIGVALLGVGGVMGFS
PAMTVGAIVSGAYFGDKMSPVSDSTNITATICETPLFTHISSMMWTTVPAALVAMAGFMLLGATQTAASGSLESLSGILA
GLENGFNLSPVVFIPPVLMVILAYRRYPVLPVMGVCLLSALLIALAGGATLDVLAKQLTTGYKAATESAQLNKLLSRGGL
MSVMPTILLLTSGMAFGGILERARVLEVLLDAMLRGSRSPVRLVASTLGSAYIILLGTGSQMLAAIIPGRAFLHAYDEND
LHRSVLSRTCEDAGTLGCPLVPWSVHAFYIMGVLGVSAYEFAPYALLNWGVPVFSILCAMTGIGMRRRDGSPVRRAPAQV
ENA
>Mature_482_residues
SGSNNRNTQDAGAGPRPGLLWAVLCFTLPVGVILYGTVFVGVRPPVLPLLAAVALAGLMCLPVGYTWKELQEGMLESLGR
VQLAVAILVMVGMTISAWLASGTIPAIIYWGLKLIAPQYFFASAFVLCAVASVATGTSFGTMGTIGVALLGVGGVMGFSP
AMTVGAIVSGAYFGDKMSPVSDSTNITATICETPLFTHISSMMWTTVPAALVAMAGFMLLGATQTAASGSLESLSGILAG
LENGFNLSPVVFIPPVLMVILAYRRYPVLPVMGVCLLSALLIALAGGATLDVLAKQLTTGYKAATESAQLNKLLSRGGLM
SVMPTILLLTSGMAFGGILERARVLEVLLDAMLRGSRSPVRLVASTLGSAYIILLGTGSQMLAAIIPGRAFLHAYDENDL
HRSVLSRTCEDAGTLGCPLVPWSVHAFYIMGVLGVSAYEFAPYALLNWGVPVFSILCAMTGIGMRRRDGSPVRRAPAQVE
NA

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50359; Mature: 50228

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSNNRNTQDAGAGPRPGLLWAVLCFTLPVGVILYGTVFVGVRPPVLPLLAAVALAGLM
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
CLPVGYTWKELQEGMLESLGRVQLAVAILVMVGMTISAWLASGTIPAIIYWGLKLIAPQY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FFASAFVLCAVASVATGTSFGTMGTIGVALLGVGGVMGFSPAMTVGAIVSGAYFGDKMSP
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
VSDSTNITATICETPLFTHISSMMWTTVPAALVAMAGFMLLGATQTAASGSLESLSGILA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHH
GLENGFNLSPVVFIPPVLMVILAYRRYPVLPVMGVCLLSALLIALAGGATLDVLAKQLTT
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GYKAATESAQLNKLLSRGGLMSVMPTILLLTSGMAFGGILERARVLEVLLDAMLRGSRSP
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
VRLVASTLGSAYIILLGTGSQMLAAIIPGRAFLHAYDENDLHRSVLSRTCEDAGTLGCPL
HHHHHHHCCCEEEEEEECCHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHHCCCCCCCC
VPWSVHAFYIMGVLGVSAYEFAPYALLNWGVPVFSILCAMTGIGMRRRDGSPVRRAPAQV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCC
ENA
CCC
>Mature Secondary Structure 
SGSNNRNTQDAGAGPRPGLLWAVLCFTLPVGVILYGTVFVGVRPPVLPLLAAVALAGLM
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
CLPVGYTWKELQEGMLESLGRVQLAVAILVMVGMTISAWLASGTIPAIIYWGLKLIAPQY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FFASAFVLCAVASVATGTSFGTMGTIGVALLGVGGVMGFSPAMTVGAIVSGAYFGDKMSP
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
VSDSTNITATICETPLFTHISSMMWTTVPAALVAMAGFMLLGATQTAASGSLESLSGILA
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHH
GLENGFNLSPVVFIPPVLMVILAYRRYPVLPVMGVCLLSALLIALAGGATLDVLAKQLTT
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GYKAATESAQLNKLLSRGGLMSVMPTILLLTSGMAFGGILERARVLEVLLDAMLRGSRSP
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
VRLVASTLGSAYIILLGTGSQMLAAIIPGRAFLHAYDENDLHRSVLSRTCEDAGTLGCPL
HHHHHHHCCCEEEEEEECCHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHHCCCCCCCC
VPWSVHAFYIMGVLGVSAYEFAPYALLNWGVPVFSILCAMTGIGMRRRDGSPVRRAPAQV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCC
ENA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]