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The map label for this gene is moaC

Identifier: 78355296

GI number: 78355296

Start: 232391

End: 232870

Strand: Direct

Name: moaC

Synonym: Dde_0249

Alternate gene names: 78355296

Gene position: 232391-232870 (Clockwise)

Preceding gene: 78355295

Following gene: 78355297

Centisome position: 6.23

GC content: 58.13

Gene sequence:

>480_bases
ATGAGCAGCGGCTTTTCACACATGGACGGCGACGGTTCCATCACCATGGTGGATGTGGGTGACAAAAAAGACACCAGACG
CACGGCCATCGTGCGCGGCAAGGTGGAAATGGCCCCTGCCACGCTGGACATGCTTGTGAAACAGGCGCTGCCCAAAGGCG
ATGTGCTTACCACGGCCAAAGTGGCAGGCATTCAGGCGGCCAAACGCACGTGGGAACTTATTCCCCTGTGCCATCCGCTG
TTTCTCAGCTATGTGGATGTGCGTTTTACCGTGGATGAATCTCTGCCCGGCGTGGTGGTGGAAGCCGAAGCCAGAACCAC
GGGGCAGACGGGTGTCGAAATGGAAGCCCTTGTGGCCGCGCAGGTTGCGGCCATGACCATTTACGACATGTGCAAGGCTG
TTCAGAAGGACATCGTGCTGCGCGACTGTCGTCTGGTGTACAAATCGGGCGGTAAAAGCGGCGAATTCAGAGCCTGCTGA

Upstream 100 bases:

>100_bases
AGCTGCTGCGCGAATTTGAGCGGCTGGAAGAGAACAGACCCCTGCGCAAGGTCAAGAATATGTTCAAAAAGGCCGGCAAG
GCCATGGGAATGGACTGAAA

Downstream 100 bases:

>100_bases
ACCACCGCGCCGACGCCGTTTCAGTAGACATGTTTCGGGCAGGGCCCCGTTCCGTCACCTGCGGAGCGGGGCCCTGTCGT
ATGTGCCGCCGTACCTGCCG

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MSSGFSHMDGDGSITMVDVGDKKDTRRTAIVRGKVEMAPATLDMLVKQALPKGDVLTTAKVAGIQAAKRTWELIPLCHPL
FLSYVDVRFTVDESLPGVVVEAEARTTGQTGVEMEALVAAQVAAMTIYDMCKAVQKDIVLRDCRLVYKSGGKSGEFRAC

Sequences:

>Translated_159_residues
MSSGFSHMDGDGSITMVDVGDKKDTRRTAIVRGKVEMAPATLDMLVKQALPKGDVLTTAKVAGIQAAKRTWELIPLCHPL
FLSYVDVRFTVDESLPGVVVEAEARTTGQTGVEMEALVAAQVAAMTIYDMCKAVQKDIVLRDCRLVYKSGGKSGEFRAC
>Mature_158_residues
SSGFSHMDGDGSITMVDVGDKKDTRRTAIVRGKVEMAPATLDMLVKQALPKGDVLTTAKVAGIQAAKRTWELIPLCHPLF
LSYVDVRFTVDESLPGVVVEAEARTTGQTGVEMEALVAAQVAAMTIYDMCKAVQKDIVLRDCRLVYKSGGKSGEFRAC

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=155, Percent_Identity=54.8387096774194, Blast_Score=165, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=42.9530201342282, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574490, Length=150, Percent_Identity=50.6666666666667, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574492, Length=137, Percent_Identity=51.8248175182482, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_DESDG (Q316U6)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386745.1
- ProteinModelPortal:   Q316U6
- SMR:   Q316U6
- STRING:   Q316U6
- GeneID:   3755070
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0249
- NMPDR:   fig|207559.3.peg.1039
- eggNOG:   COG0315
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- BioCyc:   DDES207559:DDE_0249-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 17155; Mature: 17024

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGFSHMDGDGSITMVDVGDKKDTRRTAIVRGKVEMAPATLDMLVKQALPKGDVLTTAK
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCEEECHHHHHHHHHHHCCCCCCEEHHH
VAGIQAAKRTWELIPLCHPLFLSYVDVRFTVDESLPGVVVEAEARTTGQTGVEMEALVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHH
QVAAMTIYDMCKAVQKDIVLRDCRLVYKSGGKSGEFRAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SSGFSHMDGDGSITMVDVGDKKDTRRTAIVRGKVEMAPATLDMLVKQALPKGDVLTTAK
CCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCEEECHHHHHHHHHHHCCCCCCEEHHH
VAGIQAAKRTWELIPLCHPLFLSYVDVRFTVDESLPGVVVEAEARTTGQTGVEMEALVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHH
QVAAMTIYDMCKAVQKDIVLRDCRLVYKSGGKSGEFRAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA