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The map label for this gene is icfA [H]

Identifier: 78224700

GI number: 78224700

Start: 3951277

End: 3951912

Strand: Direct

Name: icfA [H]

Synonym: Gmet_3517

Alternate gene names: 78224700

Gene position: 3951277-3951912 (Clockwise)

Preceding gene: 78224699

Following gene: 78224701

Centisome position: 98.85

GC content: 57.55

Gene sequence:

>636_bases
GTGATTACCACGCTTCTGGAAGGAAACCGGCGCTTCGTGGCCGAGACGTTCGAGAAGGAGAAGGAGTTGTTTGTCGAACT
GACGCGGGGACAGAAACCGACAGTTCTCTGGATCGGTTGCTCCGACTCGCGGGTGCCGGTCAACACCATCACCCAGACCA
AGGCCGGCGAGGTCTTCGTCCACCGCAACGTGGGGAATATCGTCGCCGCCAACGACTGGAACCTCTCCGCTGTCCTGGAA
TTCTCCATCAACCACCTGAAGATCCCCGACATCGTCATCTGCGGCCACTACGGCTGTGGCGGCATCCAGGCCCTCGACGA
GGAAAACAGCGACGACAAATACATTCCCATCTGGCTCATCAACGCCTACAAGGCAAAGGAACGGGTCGACGAAAAGCTCC
GGGCGCTCCACATAGATATTCCCCATGAGCAGCGGATGAAGCTGATCGTGGAGGAGAATGTCCGCCTCCAGCTGGAACAC
CTGCGCGAATACCCCTTTGTCCGCAGGGCCGTGGAAGAGGGAAAACTAACCCTTAACGGCTGGGTCTACGACATGGGCAA
CGGCGAGATCAGGATAGTCGCCACCGAGAGTGCGCCCAGGATCGGGAAGGGGACATGCAGCATTAAAATAAAATAA

Upstream 100 bases:

>100_bases
CCGTCCGGCTTTCCTTTGTGGATGCAGACTATACCCGGCGCCTGGAGCCCGCCGCAATCCTCGACACCCTCCGGGCAATG
CGGGATGTGGGGGGTATTCC

Downstream 100 bases:

>100_bases
CATCGTTATATTTTTCAGAAAATTTACGAACCAGCCTATTGCAATAGCCTTTCACTACTTATACAATCAACAAAACACAA
CATCAAAATCGGCTTAGCGA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MITTLLEGNRRFVAETFEKEKELFVELTRGQKPTVLWIGCSDSRVPVNTITQTKAGEVFVHRNVGNIVAANDWNLSAVLE
FSINHLKIPDIVICGHYGCGGIQALDEENSDDKYIPIWLINAYKAKERVDEKLRALHIDIPHEQRMKLIVEENVRLQLEH
LREYPFVRRAVEEGKLTLNGWVYDMGNGEIRIVATESAPRIGKGTCSIKIK

Sequences:

>Translated_211_residues
MITTLLEGNRRFVAETFEKEKELFVELTRGQKPTVLWIGCSDSRVPVNTITQTKAGEVFVHRNVGNIVAANDWNLSAVLE
FSINHLKIPDIVICGHYGCGGIQALDEENSDDKYIPIWLINAYKAKERVDEKLRALHIDIPHEQRMKLIVEENVRLQLEH
LREYPFVRRAVEEGKLTLNGWVYDMGNGEIRIVATESAPRIGKGTCSIKIK
>Mature_211_residues
MITTLLEGNRRFVAETFEKEKELFVELTRGQKPTVLWIGCSDSRVPVNTITQTKAGEVFVHRNVGNIVAANDWNLSAVLE
FSINHLKIPDIVICGHYGCGGIQALDEENSDDKYIPIWLINAYKAKERVDEKLRALHIDIPHEQRMKLIVEENVRLQLEH
LREYPFVRRAVEEGKLTLNGWVYDMGNGEIRIVATESAPRIGKGTCSIKIK

Specific function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation [H]

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=220, Percent_Identity=35.9090909090909, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786318, Length=200, Percent_Identity=36.5, Blast_Score=130, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324292, Length=197, Percent_Identity=32.48730964467, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 24024; Mature: 24024

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTLLEGNRRFVAETFEKEKELFVELTRGQKPTVLWIGCSDSRVPVNTITQTKAGEVFV
CEEEEEECCCEEEHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCEECCCCCCEEEE
HRNVGNIVAANDWNLSAVLEFSINHLKIPDIVICGHYGCGGIQALDEENSDDKYIPIWLI
EECCCCEEEECCCCEEEEEEEECCEEECCCEEEECCCCCCCCEECCCCCCCCCEEEEEEE
NAYKAKERVDEKLRALHIDIPHEQRMKLIVEENVRLQLEHLREYPFVRRAVEEGKLTLNG
ECHHHHHHHHHHHHEEEECCCCHHHEEEEEECCCEEEEHHHHCCHHHHHHHHCCCEEEEE
WVYDMGNGEIRIVATESAPRIGKGTCSIKIK
EEEECCCCEEEEEEECCCCCCCCCEEEEEEC
>Mature Secondary Structure
MITTLLEGNRRFVAETFEKEKELFVELTRGQKPTVLWIGCSDSRVPVNTITQTKAGEVFV
CEEEEEECCCEEEHHHHHHHHHEEEEECCCCCCEEEEEECCCCCCCCCEECCCCCCEEEE
HRNVGNIVAANDWNLSAVLEFSINHLKIPDIVICGHYGCGGIQALDEENSDDKYIPIWLI
EECCCCEEEECCCCEEEEEEEECCEEECCCEEEECCCCCCCCEECCCCCCCCCEEEEEEE
NAYKAKERVDEKLRALHIDIPHEQRMKLIVEENVRLQLEHLREYPFVRRAVEEGKLTLNG
ECHHHHHHHHHHHHEEEECCCCHHHEEEEEECCCEEEEHHHHCCHHHHHHHHCCCEEEEE
WVYDMGNGEIRIVATESAPRIGKGTCSIKIK
EEEECCCCEEEEEEECCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584776 [H]