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The map label for this gene is czcC [H]

Identifier: 78224690

GI number: 78224690

Start: 3936875

End: 3938182

Strand: Direct

Name: czcC [H]

Synonym: Gmet_3507

Alternate gene names: 78224690

Gene position: 3936875-3938182 (Clockwise)

Preceding gene: 78224689

Following gene: 78224691

Centisome position: 98.49

GC content: 66.13

Gene sequence:

>1308_bases
TTGTCGCGAGCGTATCGTTTCGTGCCCGGAGCGGTCCATCTGCTCCTGGCGTCATTGGTTCTTTCCCCCCAGGGAGCCTC
GGGTGAAATGCACTCGCTGACCCTGCCGCAGGCTGTGGAGTATGCCCTCGTCAACAACGGCGAGCTGAAGGCGCTGCGCG
CCGAAAAGGAGGTGGCCCGGGCCGGGCTGGAGCGGGCCGCGCTCTTTCCCAACCCCACCCTGGAGTTGTCCGGAGATACC
GGTGCCCTGACCGGCAGTTCCGGCGAGAACGTCGTCTCAATCGGCCTTTCCCAGGAATTCCTCACCGGCGGCAAGCGGGC
AAAGCGCCGGGCCGTCGCCGAGGTGGAGGCGGAGGAGGTCCGCCAGCAGATTGCCGACCGGGAAAGAACCCTTGCCCTGG
AGGTGAAGAGCACGTTTGCCGAGTTCATGCTGGCCCACAAAAGGCGGGAGCTGGCCCAGCGGGCCGTGGAACTGAACGGG
AAGCTGCTGGAGATAACGCGGGAGCGCCTGGCAGCCGGGGATATCCCGGAGCTTGAGGTGAATCTCGCCCAGGTGGAGCT
GGCTCGGAGCGAAGGGCGAAAAATCGAGACCGTGCGCGGGCTCAGCCCCCTTCTGGCCCGACTGCTGACCCTCCTGGGGC
TCCCGACAGGGGATGAGGTCAATTTAGCCGACTCTCCCGAACGGCAGCCCGTAACTATCCCCCCCGATGAGCTCACCCGC
CTCGCCCTGGAAAACCGCCCCGACCTGAAGGCGCTCCAGGCTGCCCACGACAGGGGGGACGCCGCGGTGGAACTGGCCGA
GGCGGAGCGCATCCCGAATGTGATTGTTGGAGTCGGCTACACCCACGAGCAACGGGTGGACGCCACCGGCGTCGGAGAAG
AAAAGACCCGCGACAACCTCCTGGGAATGAAACTTTCCATCCCGCTCCCCGTATTCGACCGGAACCAGGCCGGCATCCTC
GAAGCCCGGGCCAGGGCGCAGAGCGCCGGGAACCGGCTGGAGTTCGCCCGCACGGGCGTGGCCCGGGAGATCGACGGGGA
CTATGCCCGGCTGGCGACGGCGGACAAGGCCCTCGACCTCTATACCGGCGGCATCCTCCCCCAGTTGGAGGAGAACCTGA
AGATCATCCAGGAGGCCTACCAGCTGGGCGAGGTGGGGATCCTCTCAGTCATCGAGGAACAGAAGAAATACATTGAGGTC
CACGACGGCTACCTCGCCGCCCTTGCCGACCGGCAGACCGCCCTGGCGCGGCTCGAAGCCTCGGTGGGGGTCGATTTCCA
GAACAAGACCAGCGGAGGTGCGCAGTGA

Upstream 100 bases:

>100_bases
AGCCGTGGGGAATTCGTGCGCCCTTAGTCCGAATTTCCACCCTTCAGCGCCACTCTGTCACCCACAATTCAACCCAGCAA
ATCAGCAAGGAGGTGCTGTC

Downstream 100 bases:

>100_bases
ACAGGAAAAACGGAATCATAATCGGCATCATCCTGGCCATGGCCGTCGGCGGTGCCTTTGTCTATCGCTCTACCCATGTG
AAAGGGGGCGCCGGCGAGCA

Product: Outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSRAYRFVPGAVHLLLASLVLSPQGASGEMHSLTLPQAVEYALVNNGELKALRAEKEVARAGLERAALFPNPTLELSGDT
GALTGSSGENVVSIGLSQEFLTGGKRAKRRAVAEVEAEEVRQQIADRERTLALEVKSTFAEFMLAHKRRELAQRAVELNG
KLLEITRERLAAGDIPELEVNLAQVELARSEGRKIETVRGLSPLLARLLTLLGLPTGDEVNLADSPERQPVTIPPDELTR
LALENRPDLKALQAAHDRGDAAVELAEAERIPNVIVGVGYTHEQRVDATGVGEEKTRDNLLGMKLSIPLPVFDRNQAGIL
EARARAQSAGNRLEFARTGVAREIDGDYARLATADKALDLYTGGILPQLEENLKIIQEAYQLGEVGILSVIEEQKKYIEV
HDGYLAALADRQTALARLEASVGVDFQNKTSGGAQ

Sequences:

>Translated_435_residues
MSRAYRFVPGAVHLLLASLVLSPQGASGEMHSLTLPQAVEYALVNNGELKALRAEKEVARAGLERAALFPNPTLELSGDT
GALTGSSGENVVSIGLSQEFLTGGKRAKRRAVAEVEAEEVRQQIADRERTLALEVKSTFAEFMLAHKRRELAQRAVELNG
KLLEITRERLAAGDIPELEVNLAQVELARSEGRKIETVRGLSPLLARLLTLLGLPTGDEVNLADSPERQPVTIPPDELTR
LALENRPDLKALQAAHDRGDAAVELAEAERIPNVIVGVGYTHEQRVDATGVGEEKTRDNLLGMKLSIPLPVFDRNQAGIL
EARARAQSAGNRLEFARTGVAREIDGDYARLATADKALDLYTGGILPQLEENLKIIQEAYQLGEVGILSVIEEQKKYIEV
HDGYLAALADRQTALARLEASVGVDFQNKTSGGAQ
>Mature_434_residues
SRAYRFVPGAVHLLLASLVLSPQGASGEMHSLTLPQAVEYALVNNGELKALRAEKEVARAGLERAALFPNPTLELSGDTG
ALTGSSGENVVSIGLSQEFLTGGKRAKRRAVAEVEAEEVRQQIADRERTLALEVKSTFAEFMLAHKRRELAQRAVELNGK
LLEITRERLAAGDIPELEVNLAQVELARSEGRKIETVRGLSPLLARLLTLLGLPTGDEVNLADSPERQPVTIPPDELTRL
ALENRPDLKALQAAHDRGDAAVELAEAERIPNVIVGVGYTHEQRVDATGVGEEKTRDNLLGMKLSIPLPVFDRNQAGILE
ARARAQSAGNRLEFARTGVAREIDGDYARLATADKALDLYTGGILPQLEENLKIIQEAYQLGEVGILSVIEEQKKYIEVH
DGYLAALADRQTALARLEASVGVDFQNKTSGGAQ

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47114; Mature: 46983

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAYRFVPGAVHLLLASLVLSPQGASGEMHSLTLPQAVEYALVNNGELKALRAEKEVAR
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHCCCCCEEHHHHHHHHHH
AGLERAALFPNPTLELSGDTGALTGSSGENVVSIGLSQEFLTGGKRAKRRAVAEVEAEEV
HCHHHHCCCCCCCEEECCCCCEEECCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHHHHH
RQQIADRERTLALEVKSTFAEFMLAHKRRELAQRAVELNGKLLEITRERLAAGDIPELEV
HHHHHCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEE
NLAQVELARSEGRKIETVRGLSPLLARLLTLLGLPTGDEVNLADSPERQPVTIPPDELTR
EHHHHHHHHHCCCEEHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LALENRPDLKALQAAHDRGDAAVELAEAERIPNVIVGVGYTHEQRVDATGVGEEKTRDNL
HHHCCCCCHHHHHHHHCCCCHHEEHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHH
LGMKLSIPLPVFDRNQAGILEARARAQSAGNRLEFARTGVAREIDGDYARLATADKALDL
CCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHCCCCHHHHHHHHHHHHH
YTGGILPQLEENLKIIQEAYQLGEVGILSVIEEQKKYIEVHDGYLAALADRQTALARLEA
HCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
SVGVDFQNKTSGGAQ
HHCCCCCCCCCCCCC
>Mature Secondary Structure 
SRAYRFVPGAVHLLLASLVLSPQGASGEMHSLTLPQAVEYALVNNGELKALRAEKEVAR
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHCCCCCEEHHHHHHHHHH
AGLERAALFPNPTLELSGDTGALTGSSGENVVSIGLSQEFLTGGKRAKRRAVAEVEAEEV
HCHHHHCCCCCCCEEECCCCCEEECCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHHHHH
RQQIADRERTLALEVKSTFAEFMLAHKRRELAQRAVELNGKLLEITRERLAAGDIPELEV
HHHHHCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEE
NLAQVELARSEGRKIETVRGLSPLLARLLTLLGLPTGDEVNLADSPERQPVTIPPDELTR
EHHHHHHHHHCCCEEHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LALENRPDLKALQAAHDRGDAAVELAEAERIPNVIVGVGYTHEQRVDATGVGEEKTRDNL
HHHCCCCCHHHHHHHHCCCCHHEEHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHH
LGMKLSIPLPVFDRNQAGILEARARAQSAGNRLEFARTGVAREIDGDYARLATADKALDL
CCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHCCCCHHHHHHHHHHHHH
YTGGILPQLEENLKIIQEAYQLGEVGILSVIEEQKKYIEVHDGYLAALADRQTALARLEA
HCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHH
SVGVDFQNKTSGGAQ
HHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]