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The map label for this gene is queC

Identifier: 78224267

GI number: 78224267

Start: 3473550

End: 3474263

Strand: Reverse

Name: queC

Synonym: Gmet_3075

Alternate gene names: 78224267

Gene position: 3474263-3473550 (Counterclockwise)

Preceding gene: 78224268

Following gene: 78224266

Centisome position: 86.91

GC content: 65.13

Gene sequence:

>714_bases
ATGCACAAAAAAGCCGTCGTCCTCTACAGCGGAGGACTCGATTCCACCACCTGTCTCGCCATCGCCCGGGCCGAAGGGTA
TGAGCCCTACGCCATGAGTTTCTCCTACGGCCAGCGCCACAGCGTTGAGCTGGAGCAGGCCAAGCGCAACGCTCGCCCCA
TGGGCGCCGTGGACCATCTGGTCGTGGAGTTCGATTACCGCCAGGTGGGGGGAAGCGCCCTCACCAGCGACATCGCCGTC
CCCAAGGAAGGTGTGGGGAGCGACATCCCGGTCACCTACGTGCCGGCCCGCAACACGGTCTTTCTCTCCTTCGCCCTGGG
ATGGGCCGAGGTGCTCGGCGCCTTCGACATCTTCATCGGCGTCAACGCCCTGGACTACTCCGGCTACCCGGACTGTCGGC
CGGAATACATCGCCGCCTTCGAGGCCATGGCCAATCTTGCCACCAAGGCCGGGGTGGAAGGGAAGGGGCGGTTCCGCATC
CACACCCCCCTGATCCACCTCACCAAGGCCGAGATCATCCGCAAGGGGCTCTCCCTCGGCGTCGACTACGGCCGGACCCA
CTCCTGCTACGACCCCACGCCCGAAGGGCTTGCCTGCGGCCTCTGCGACTCCTGCCGCCTGCGGCTCAAGGGGTTTGCGG
AGGCCGGGGTGGCGGACCCGGTTGCGTACGCAACCATCAAGAATCCAGAAGTTAGGAGTCAGGAGTCAGAATAG

Upstream 100 bases:

>100_bases
TCATCGTTCGACAACAAGCTCAACGGGGCAGCCGAGGCCGAGGGGTTCGCCCTGCTCGCGGCAGGTCACTAGTCCGACAT
TCGGGAAGGAACTACATCCG

Downstream 100 bases:

>100_bases
AAGATGCCTGGTTTTTTCTGGCTCCTGAATTCTGACTCCTGAATACCCAGAGGTTGTTATGACCACCATGCCCGACATGC
AGAAAACCTCCGACACCCGG

Product: ExsB

Products: NA

Alternate protein names: 7-cyano-7-carbaguanine synthase; PreQ(0) synthase; Queuosine biosynthesis protein queC

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MHKKAVVLYSGGLDSTTCLAIARAEGYEPYAMSFSYGQRHSVELEQAKRNARPMGAVDHLVVEFDYRQVGGSALTSDIAV
PKEGVGSDIPVTYVPARNTVFLSFALGWAEVLGAFDIFIGVNALDYSGYPDCRPEYIAAFEAMANLATKAGVEGKGRFRI
HTPLIHLTKAEIIRKGLSLGVDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVADPVAYATIKNPEVRSQESE

Sequences:

>Translated_237_residues
MHKKAVVLYSGGLDSTTCLAIARAEGYEPYAMSFSYGQRHSVELEQAKRNARPMGAVDHLVVEFDYRQVGGSALTSDIAV
PKEGVGSDIPVTYVPARNTVFLSFALGWAEVLGAFDIFIGVNALDYSGYPDCRPEYIAAFEAMANLATKAGVEGKGRFRI
HTPLIHLTKAEIIRKGLSLGVDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVADPVAYATIKNPEVRSQESE
>Mature_237_residues
MHKKAVVLYSGGLDSTTCLAIARAEGYEPYAMSFSYGQRHSVELEQAKRNARPMGAVDHLVVEFDYRQVGGSALTSDIAV
PKEGVGSDIPVTYVPARNTVFLSFALGWAEVLGAFDIFIGVNALDYSGYPDCRPEYIAAFEAMANLATKAGVEGKGRFRI
HTPLIHLTKAEIIRKGLSLGVDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVADPVAYATIKNPEVRSQESE

Specific function: Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))

COG id: COG0603

COG function: function code R; Predicted PP-loop superfamily ATPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the queC family

Homologues:

Organism=Escherichia coli, GI1786648, Length=236, Percent_Identity=37.2881355932203, Blast_Score=125, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): QUEC_GEOMG (Q39R35)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386014.1
- ProteinModelPortal:   Q39R35
- SMR:   Q39R35
- STRING:   Q39R35
- GeneID:   3740773
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3075
- NMPDR:   fig|269799.3.peg.3190
- eggNOG:   COG0603
- HOGENOM:   HBG553284
- OMA:   GWAEVLG
- PhylomeDB:   Q39R35
- ProtClustDB:   CLSK827865
- BioCyc:   GMET269799:GMET_3075-MONOMER
- HAMAP:   MF_01633_B
- InterPro:   IPR001518
- InterPro:   IPR018317
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- PIRSF:   PIRSF006293
- TIGRFAMs:   TIGR00364

Pfam domain/function: PF06508 ExsB

EC number: NA

Molecular weight: Translated: 25616; Mature: 25616

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKAVVLYSGGLDSTTCLAIARAEGYEPYAMSFSYGQRHSVELEQAKRNARPMGAVDHL
CCCCEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEHHHHHCCCCCCCCCEEE
VVEFDYRQVGGSALTSDIAVPKEGVGSDIPVTYVPARNTVFLSFALGWAEVLGAFDIFIG
EEEECHHHCCCHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEEHHHHHHHHHHHHHEEE
VNALDYSGYPDCRPEYIAAFEAMANLATKAGVEGKGRFRIHTPLIHLTKAEIIRKGLSLG
CEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEHHHHHHHHHHHHCC
VDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVADPVAYATIKNPEVRSQESE
CCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MHKKAVVLYSGGLDSTTCLAIARAEGYEPYAMSFSYGQRHSVELEQAKRNARPMGAVDHL
CCCCEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEHHHHHCCCCCCCCCEEE
VVEFDYRQVGGSALTSDIAVPKEGVGSDIPVTYVPARNTVFLSFALGWAEVLGAFDIFIG
EEEECHHHCCCHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEEEHHHHHHHHHHHHHEEE
VNALDYSGYPDCRPEYIAAFEAMANLATKAGVEGKGRFRIHTPLIHLTKAEIIRKGLSLG
CEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEHHHHHHHHHHHHCC
VDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVADPVAYATIKNPEVRSQESE
CCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA