Click here to switch to the map view.

The map label for this gene is apt

Identifier: 78222634

GI number: 78222634

Start: 1589661

End: 1590176

Strand: Direct

Name: apt

Synonym: Gmet_1422

Alternate gene names: 78222634

Gene position: 1589661-1590176 (Clockwise)

Preceding gene: 78222633

Following gene: 78222635

Centisome position: 39.77

GC content: 49.81

Gene sequence:

>516_bases
ATGGATGAACTCAAAAATATAATACGTGACATACCCGATTTCCCCAAAAAAGGGATTGTCTTTAAGGATATCACGACGCT
TCTCGCAGATGCGAAGTCGTTTCAGCGTATGGTTGATCTGCTGGCGCACCGCTACGTGGGGGAGAAGATAGACAAGGTGG
TGGGGGTTGAGGCCCGGGGGTTCATCCTGGGTGCAGCCCTTGCGTACAAGCTTGGGGCTGGAGTGGTTCTTGTGCGCAAA
CCGGGGAAACTTCCTTCCGAAACCTTCAGTAAAACATATCAGCTTGAATATGGCACTGACTCCCTGGAAATTCATACTGA
CGCCATCCGAAAGGGAGAGAAAGTGCTCATTGCCGACGACGTTCTTGCTACTGGAGGGACTATGTCCGCTGTTGTTGAGA
TGGTCAGGGACCTTGGCGGTGAAATTGTAGAATGCTGCTTTTTGGCAGAACTCGATTTTCTTGGTGGAAGAAAGAAACTG
CCGGACGGGAAGGTCTTTTCACTCCTTACGTTTTGA

Upstream 100 bases:

>100_bases
AGATAGAGGCGAAATCTCTCGAAAAGCTCAGAAAATACATCGATAACAGTGATGGAAGTGCAATCGAGTGATTGATTTTG
AATTCTGTGGAGGGTAGGGA

Downstream 100 bases:

>100_bases
ACGACTAGCTGCGGCTTGAATCCCGTGTGATCATAGGGAAAAGGGTTGCAAAGCGAAGTGCGGTGGGCTATAAACAAGCT
TCTTGTCCCCGTAGCTCAGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MDELKNIIRDIPDFPKKGIVFKDITTLLADAKSFQRMVDLLAHRYVGEKIDKVVGVEARGFILGAALAYKLGAGVVLVRK
PGKLPSETFSKTYQLEYGTDSLEIHTDAIRKGEKVLIADDVLATGGTMSAVVEMVRDLGGEIVECCFLAELDFLGGRKKL
PDGKVFSLLTF

Sequences:

>Translated_171_residues
MDELKNIIRDIPDFPKKGIVFKDITTLLADAKSFQRMVDLLAHRYVGEKIDKVVGVEARGFILGAALAYKLGAGVVLVRK
PGKLPSETFSKTYQLEYGTDSLEIHTDAIRKGEKVLIADDVLATGGTMSAVVEMVRDLGGEIVECCFLAELDFLGGRKKL
PDGKVFSLLTF
>Mature_171_residues
MDELKNIIRDIPDFPKKGIVFKDITTLLADAKSFQRMVDLLAHRYVGEKIDKVVGVEARGFILGAALAYKLGAGVVLVRK
PGKLPSETFSKTYQLEYGTDSLEIHTDAIRKGEKVLIADDVLATGGTMSAVVEMVRDLGGEIVECCFLAELDFLGGRKKL
PDGKVFSLLTF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=47.3053892215569, Blast_Score=155, Evalue=1e-38,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=53.757225433526, Blast_Score=186, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=40.9356725146199, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=44.5086705202312, Blast_Score=134, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=38.0116959064327, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=42.1965317919075, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_GEOMG (Q39VR8)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384381.1
- HSSP:   P07741
- ProteinModelPortal:   Q39VR8
- SMR:   Q39VR8
- STRING:   Q39VR8
- GeneID:   3738551
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1422
- NMPDR:   fig|269799.3.peg.1263
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q39VR8
- ProtClustDB:   PRK02304
- BioCyc:   GMET269799:GMET_1422-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18722; Mature: 18722

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELKNIIRDIPDFPKKGIVFKDITTLLADAKSFQRMVDLLAHRYVGEKIDKVVGVEARG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
FILGAALAYKLGAGVVLVRKPGKLPSETFSKTYQLEYGTDSLEIHTDAIRKGEKVLIADD
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHEEEEEECCCCEEEEHHHHHCCCEEEEECC
VLATGGTMSAVVEMVRDLGGEIVECCFLAELDFLGGRKKLPDGKVFSLLTF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MDELKNIIRDIPDFPKKGIVFKDITTLLADAKSFQRMVDLLAHRYVGEKIDKVVGVEARG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
FILGAALAYKLGAGVVLVRKPGKLPSETFSKTYQLEYGTDSLEIHTDAIRKGEKVLIADD
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHEEEEEECCCCEEEEHHHHHCCCEEEEECC
VLATGGTMSAVVEMVRDLGGEIVECCFLAELDFLGGRKKLPDGKVFSLLTF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA