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The map label for this gene is dxr

Identifier: 78222470

GI number: 78222470

Start: 1415278

End: 1416432

Strand: Direct

Name: dxr

Synonym: Gmet_1256

Alternate gene names: 78222470

Gene position: 1415278-1416432 (Clockwise)

Preceding gene: 78222469

Following gene: 78222471

Centisome position: 35.4

GC content: 59.22

Gene sequence:

>1155_bases
ATGAAAAAACTCACCATTCTTGGCTCAACCGGTTCCATCGGGACCAGCACTCTGGAGATCGTCGCAGCGCACCCGGACCG
ATTCCAGGTGATTGCCCTCACGGCGGGGAGTAACCTGGAGCTTCTCAAACAACAGGTTGAAGTGTTTCGGCCCAGGCTTG
TCAGCGTTCTGACCGCTGACCTGGCCCGACAGTTGGACCGGATGCTCTCGGATCCGAAACCGGAAATCCATCATGGGATT
CCCGGTCTTATCGCCGCTGCCACTGCCGGTGAGGCCGATGTCGTGGTTGCCGCTATTGTTGGGGCTGCCGGCCTCGTGCC
GACCGCCGCCGCAATCAAGGCCGGCAAGGACGTCGCCTTGGCAAATAAGGAGACCCTTGTCACCGCCGGCCGGATCATGA
TGGACCTCGTCAGGGAAAACGGGGTCAGGCTCTATCCTGTCGACAGCGAGCACTCGGCGGTCTTTCAGTCCCTGGAGGGG
CAGAGCGGAAAGGATGTGAAGCGGATTATTCTGACCGCATCGGGGGGACCATTTCTGAATCTTCCCCTTGACCGCCTTTC
ACGGGTTTCGGTCGCCGATGCCCTCAATCACCCCAACTGGAGCATGGGGCAAAAGATAACCATCGACTCGGCCACCATGA
TGAACAAGGGATTGGAGGTGATCGAGGCCCGCTGGCTTTTTGACACGCCGGCGGAGCGGATTGCCGTGAATATTCACCCC
CAGAGCATCATTCACTCCATGGTTGAGTATGTGGACGGCTGTGTTATGGCCCAGTTGGGGGTTCCCGACATGAAGGCCCC
CATTGCCTATGCCTTGACCTATCCGGAACGGATTCCTACGGGGGTGAAGCCCCTTGACCTGACCGCGTTGTCCGGACTCA
CCTTCCTGGCTCCCGACTATCAGCGCTTCCCCGCCTTGAAACTGGCCTACGATGCCCTTGCCGCTGGAGAAAGCATGCCG
GCGGTCATGAACGCCGCCAACGAGGTGGCTGTCGAGGCCTTCCTCAAGGGGAAAATCGGGTTTACCGGTATCGCCACTTC
TATCGCTCGAACCATGGATGCACACGAGCCCCATACCCTTGCCACCATCGAGGATGTCCTTTCCTCTGACCTCTGGGCGA
GGGAGAAGAGCAGGGAGCTCATAGGGTTGTCCTGA

Upstream 100 bases:

>100_bases
CATCCTCGACCGGCTCGACAGCATTCTTTTTGCCGCACCCGCACTGTATTACTATGCCTATCTGGTGGTCATGGCCCGAT
AGGTTTCCTGACGAGGGAAC

Downstream 100 bases:

>100_bases
CGGGATGTCCGTCACCTTTATCGAGGCACCAGATGACCAGTATCGTTTCGGCAATTATTGTTCTCGGCATACTCATCTTT
GTTCACGAGTTTGGGCACTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTADLARQLDRMLSDPKPEIHHGI
PGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVALANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEG
QSGKDVKRIILTASGGPFLNLPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHP
QSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDYQRFPALKLAYDALAAGESMP
AVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTLATIEDVLSSDLWAREKSRELIGLS

Sequences:

>Translated_384_residues
MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTADLARQLDRMLSDPKPEIHHGI
PGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVALANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEG
QSGKDVKRIILTASGGPFLNLPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHP
QSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDYQRFPALKLAYDALAAGESMP
AVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTLATIEDVLSSDLWAREKSRELIGLS
>Mature_384_residues
MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTADLARQLDRMLSDPKPEIHHGI
PGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVALANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEG
QSGKDVKRIILTASGGPFLNLPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHP
QSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDYQRFPALKLAYDALAAGESMP
AVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTLATIEDVLSSDLWAREKSRELIGLS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=50.7575757575758, Blast_Score=365, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_GEOMG (Q39W82)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384217.1
- ProteinModelPortal:   Q39W82
- SMR:   Q39W82
- STRING:   Q39W82
- GeneID:   3738799
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1256
- NMPDR:   fig|269799.3.peg.1934
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q39W82
- ProtClustDB:   PRK05447
- BioCyc:   GMET269799:GMET_1256-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 40966; Mature: 40966

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTAD
CCEEEEEECCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LARQLDRMLSDPKPEIHHGIPGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVAL
HHHHHHHHHCCCCCHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEE
ANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEGQSGKDVKRIILTASGGPFLN
CCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEE
LPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHEEECCCCCCCHHEEEEECH
QSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDY
HHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECHHHCCCCCCCCCHHHHCCCEEECCCH
QRFPALKLAYDALAAGESMPAVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTL
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHH
ATIEDVLSSDLWAREKSRELIGLS
HHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTAD
CCEEEEEECCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LARQLDRMLSDPKPEIHHGIPGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVAL
HHHHHHHHHCCCCCHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEE
ANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEGQSGKDVKRIILTASGGPFLN
CCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCEEE
LPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHEEECCCCCCCHHEEEEECH
QSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDY
HHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECHHHCCCCCCCCCHHHHCCCEEECCCH
QRFPALKLAYDALAAGESMPAVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTL
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHH
ATIEDVLSSDLWAREKSRELIGLS
HHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA