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The map label for this gene is dsbC [C]

Identifier: 78222366

GI number: 78222366

Start: 1276759

End: 1277562

Strand: Direct

Name: dsbC [C]

Synonym: Gmet_1150

Alternate gene names: 78222366

Gene position: 1276759-1277562 (Clockwise)

Preceding gene: 78222363

Following gene: 78222367

Centisome position: 31.94

GC content: 56.72

Gene sequence:

>804_bases
ATGCGACTTCAACTGTTACGATTCGTGGGGGCACTTTCCCTGACAGCGTGCCTCGCTGCACCGACTGCCTTTGCGGCGCC
GAAAGAACAAGCCAAGGGGGAAACCCCTGAGGCGGCCGTAAAACGGCTCTTTCCGAAGCTTCCCGCCACCGCGGTGAAAA
AAACCGATATCGACGGGTTCTATGAGGTTGTGGCTGACGGGAATATTCTCTATGTCAACGTGAAGACCGGTCACGTGTTT
GTGGGTGACATTTTTACGCGGGAGGGGAAAAACCTGACGGCCGAGGCTCGCACCCGCCTCACTGCCGAGCGCTATAAGCT
CATTACCGAGGCCGACAAAGAGAAGGCGGTGAAGGTGGGGAACGGCAAGCATGTGGTCATCGAGATCACCGACCCCGACT
GCCCCTTCTGCCGCAAGATGCATGAGTACTGGGGAAACCGTCCCGATGTGACGCGTTATGTTTTCTTCCTCCCCCTTGCG
ATGCATAAGGATGCTGAAAAGAAGGCCCGCTATATCCTGGCGGCCGACAATAAGGAACAAGCCCTCTGGGAGGTCTATTC
GGGGGAACTCGACAATAACCGCGAGAAGCTGAACAAGCCCTATGACGACAAGGGGTTGCTCTCCGCGCACAAGGCGGTGG
TGGCAAAGCTCGGCATCCAGTCGACCCCTGCCTTCTGGGTAGACGGTACTTTTGTGAATGGCGCGAATATCCCGCTTATC
GAAAAGATCATCGGCAAGTGCAACCTCCGGCAAGGAACTGCTCCAGGTGAGCCGAAGGTGTGCGATGATGAGCAGGGGAA
GTGA

Upstream 100 bases:

>100_bases
TATCGGCACAGATGTAACTTGATGAATATGGTATTAAATGGTATCAATTTGCCTGAAGGATATGGTTGCGAAATTACCCA
GAAATTCTTTCGGAGGATCT

Downstream 100 bases:

>100_bases
CCGGGGAGCAGGTTAACCATCAGTGATCCCGATAAAGGACTATAATCCGACGCGACGCTTTCCCTTGGTGAGCGTCGCTT
TTATCGTTCTGAATGTCATC

Product: hypothetical protein

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: ThiolDisulphide Interchange Protein; ThiolDisulfide Interchange Protein DsbC; ThiolDisulfide Interchange Protein; Thiol-Disulfide Interchange Protein DsbC; Disulfide Bond Isomerase DsbC/G-Like Protein; Protein-Disulfide Isomerase-Like Protein; Protein Disulfide-Isomerase; Protein Disulfide Bond Isomerase DsbC/DsbG-Like Protein; ThiolDisulfide Interchange Protein DsbA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MRLQLLRFVGALSLTACLAAPTAFAAPKEQAKGETPEAAVKRLFPKLPATAVKKTDIDGFYEVVADGNILYVNVKTGHVF
VGDIFTREGKNLTAEARTRLTAERYKLITEADKEKAVKVGNGKHVVIEITDPDCPFCRKMHEYWGNRPDVTRYVFFLPLA
MHKDAEKKARYILAADNKEQALWEVYSGELDNNREKLNKPYDDKGLLSAHKAVVAKLGIQSTPAFWVDGTFVNGANIPLI
EKIIGKCNLRQGTAPGEPKVCDDEQGK

Sequences:

>Translated_267_residues
MRLQLLRFVGALSLTACLAAPTAFAAPKEQAKGETPEAAVKRLFPKLPATAVKKTDIDGFYEVVADGNILYVNVKTGHVF
VGDIFTREGKNLTAEARTRLTAERYKLITEADKEKAVKVGNGKHVVIEITDPDCPFCRKMHEYWGNRPDVTRYVFFLPLA
MHKDAEKKARYILAADNKEQALWEVYSGELDNNREKLNKPYDDKGLLSAHKAVVAKLGIQSTPAFWVDGTFVNGANIPLI
EKIIGKCNLRQGTAPGEPKVCDDEQGK
>Mature_267_residues
MRLQLLRFVGALSLTACLAAPTAFAAPKEQAKGETPEAAVKRLFPKLPATAVKKTDIDGFYEVVADGNILYVNVKTGHVF
VGDIFTREGKNLTAEARTRLTAERYKLITEADKEKAVKVGNGKHVVIEITDPDCPFCRKMHEYWGNRPDVTRYVFFLPLA
MHKDAEKKARYILAADNKEQALWEVYSGELDNNREKLNKPYDDKGLLSAHKAVVAKLGIQSTPAFWVDGTFVNGANIPLI
EKIIGKCNLRQGTAPGEPKVCDDEQGK

Specific function: Required For Disulfide Bond Formation In Some Periplasmic Proteins. Acts By Transferring Its Disulfide Bond To Other Proteins And Is Reduced In The Process. Dsbc Is Reoxidized By A Yet Uncharacterized Protein. Also Acts As A Disulfide Isomerase. [C]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789260, Length=236, Percent_Identity=27.1186440677966, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 29604; Mature: 29604

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLQLLRFVGALSLTACLAAPTAFAAPKEQAKGETPEAAVKRLFPKLPATAVKKTDIDGF
CHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCHH
YEVVADGNILYVNVKTGHVFVGDIFTREGKNLTAEARTRLTAERYKLITEADKEKAVKVG
HHHEECCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHEEEEC
NGKHVVIEITDPDCPFCRKMHEYWGNRPDVTRYVFFLPLAMHKDAEKKARYILAADNKEQ
CCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCEEEEEECCCHH
ALWEVYSGELDNNREKLNKPYDDKGLLSAHKAVVAKLGIQSTPAFWVDGTFVNGANIPLI
HHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCEEECCCCCHHH
EKIIGKCNLRQGTAPGEPKVCDDEQGK
HHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLQLLRFVGALSLTACLAAPTAFAAPKEQAKGETPEAAVKRLFPKLPATAVKKTDIDGF
CHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCHH
YEVVADGNILYVNVKTGHVFVGDIFTREGKNLTAEARTRLTAERYKLITEADKEKAVKVG
HHHEECCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHEEEEC
NGKHVVIEITDPDCPFCRKMHEYWGNRPDVTRYVFFLPLAMHKDAEKKARYILAADNKEQ
CCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCEEEEEECCCHH
ALWEVYSGELDNNREKLNKPYDDKGLLSAHKAVVAKLGIQSTPAFWVDGTFVNGANIPLI
HHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCEEECCCCCHHH
EKIIGKCNLRQGTAPGEPKVCDDEQGK
HHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA