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The map label for this gene is cat1 [H]

Identifier: 78222341

GI number: 78222341

Start: 1245850

End: 1247445

Strand: Direct

Name: cat1 [H]

Synonym: Gmet_1125

Alternate gene names: 78222341

Gene position: 1245850-1247445 (Clockwise)

Preceding gene: 78222340

Following gene: 78222342

Centisome position: 31.17

GC content: 60.4

Gene sequence:

>1596_bases
ATGGCAAAATACGGAACACTGCAGGAGCGCGTGCGCTGCACGTCATTGCTGGGCAAAGTCATGAAGGCGGAAGAAACCAT
CCCCTTCTTCAAGAACGGGATGAACCTCGGCTGGTCGGGCTTCACCCCCGCCGGGTATCCCAAAGCGGTCCCCATCGCCC
TCGCCGACCATGTGGAGAAGAACAACCTCCAGGGGAAACTGCGCTTCAGCATCTTCACCGGGGCATCGGTCGGGGCCGAA
ACGGAAGACCGCTGGGCGACCCTGGACATGATCGACCGCCGCTGGCCGTACCAGACCGGCAAGAACATCGCCGCAGGGAT
CAATGAGGGACGTATCCGGATGGGGGACAAACACCTCTCCCTCTTCGCCCAGGATCTCGGTTACGGCTTTTACACAAAGG
ACACCCCGAGCGGCAAGCTGGATCTGGCGATTATCGAGGTGTCGGCAATTACGGAGGACGGCGGGCTCGTGCCGACCTCT
TCCGGCGGTGTCATCCCCGAAATCCTCATGATGTGCGACCACGTCATCGTCGAGGTCAATGTCGGGCAGCCCTCCTTCGA
GGGGATGCATGACAACATCATCTGCGACAACCCGCCGAACAGGCAGGTCCTGAACATCACGAGGGCAGATTCCCGGATCG
GCACCACCGCTGTCCCGTGCGATCCATCCAAGATCATTGCCGTTGTGGAGTCGGAGTATCGGGACAACGGCCGGGCCTTT
TCCGAACAGGACGAGACATCCGAGGCCATAGCCAACCACATCATCGACTTCTTCAGCCACGAAGTGAAGGCCGGCCGCCT
GCCGAAAAATCTCCTGCCGCTCCAGTCGGGGGTCGGCTCCATCGCCAACGCCGTCATCGGCGGCCTGGCCAAGGGGCCAT
TCAGCGATCTCAGCGTCTACACCGAGGTGTTGCAGGATACCATGCTCGACCTGATCGATTCGGGCAAGCTCAACTGCGCC
TCGTCCTGCTCGCTCTCCCTTTCCAAGGATGAGGGGTTCCCGCGCTTCTTTGCCAACATGGACAAGTATGCGAACAAAAT
CCTGCTCCGTCCGCTTTCCATCTCCAACGCACCGGAACCCATCCGGCGACTCGGTGTTATCGCCATGAACACCCCGGTGG
AGATCGATATCTACGCCCACGCCAACTCGACCCTCGTCGGTGGGACGAGGATGATCAACGGTATCGGCGGCTCCGGTGAT
TTCCTCCGCAACGGCTATCTCAAGATCATGCACACCCCGTCGAGCCGCCCCACCAAGACCGATCCCACCGGCATCACCTG
TGTCGTGCCCCACTGCTCCCACATCGACCACACGGAGCACGACCTCGATTGCGTGGTGACCGAGCAGGGTCTTGCCGATC
TGCGGGGGCTGGCGCCGAAGGAGCGCGCCCGGCGCATTATCGAGAAGTGCGCCCATCCCGACTACAAGCCGATCCTCTTC
GCGTATCTGGAAATTGCGACCAAGGAGTGCATGGCGCGGAAGGTGGGCCACGAGCCCCAGGTGTGGGATCGCGCCTTCAA
AATGCAGCTGAATCTGGCCCAGAACGGCACCATGAAGATCAAAAACTGGGATATGAAGATAGACCTGTGTGAATAA

Upstream 100 bases:

>100_bases
CCCCATGCTCGAAGAGTGGGCCGCTAAAGGTGGCCGTCTGTAGTATCCGCGGTAAATGCGTAGCTTTACCGTATACATAG
AAAACAAACAGGAGTTTACA

Downstream 100 bases:

>100_bases
CCACGCGACGCTGATAAGGAGGTGTTAATTATGGCCACAAATCCGCAAGACACGGCTGCTGTATTCGAACTGAACGATAC
GACGGCCAATCCGGCGCCGC

Product: Acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAKYGTLQERVRCTSLLGKVMKAEETIPFFKNGMNLGWSGFTPAGYPKAVPIALADHVEKNNLQGKLRFSIFTGASVGAE
TEDRWATLDMIDRRWPYQTGKNIAAGINEGRIRMGDKHLSLFAQDLGYGFYTKDTPSGKLDLAIIEVSAITEDGGLVPTS
SGGVIPEILMMCDHVIVEVNVGQPSFEGMHDNIICDNPPNRQVLNITRADSRIGTTAVPCDPSKIIAVVESEYRDNGRAF
SEQDETSEAIANHIIDFFSHEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSDLSVYTEVLQDTMLDLIDSGKLNCA
SSCSLSLSKDEGFPRFFANMDKYANKILLRPLSISNAPEPIRRLGVIAMNTPVEIDIYAHANSTLVGGTRMINGIGGSGD
FLRNGYLKIMHTPSSRPTKTDPTGITCVVPHCSHIDHTEHDLDCVVTEQGLADLRGLAPKERARRIIEKCAHPDYKPILF
AYLEIATKECMARKVGHEPQVWDRAFKMQLNLAQNGTMKIKNWDMKIDLCE

Sequences:

>Translated_531_residues
MAKYGTLQERVRCTSLLGKVMKAEETIPFFKNGMNLGWSGFTPAGYPKAVPIALADHVEKNNLQGKLRFSIFTGASVGAE
TEDRWATLDMIDRRWPYQTGKNIAAGINEGRIRMGDKHLSLFAQDLGYGFYTKDTPSGKLDLAIIEVSAITEDGGLVPTS
SGGVIPEILMMCDHVIVEVNVGQPSFEGMHDNIICDNPPNRQVLNITRADSRIGTTAVPCDPSKIIAVVESEYRDNGRAF
SEQDETSEAIANHIIDFFSHEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSDLSVYTEVLQDTMLDLIDSGKLNCA
SSCSLSLSKDEGFPRFFANMDKYANKILLRPLSISNAPEPIRRLGVIAMNTPVEIDIYAHANSTLVGGTRMINGIGGSGD
FLRNGYLKIMHTPSSRPTKTDPTGITCVVPHCSHIDHTEHDLDCVVTEQGLADLRGLAPKERARRIIEKCAHPDYKPILF
AYLEIATKECMARKVGHEPQVWDRAFKMQLNLAQNGTMKIKNWDMKIDLCE
>Mature_530_residues
AKYGTLQERVRCTSLLGKVMKAEETIPFFKNGMNLGWSGFTPAGYPKAVPIALADHVEKNNLQGKLRFSIFTGASVGAET
EDRWATLDMIDRRWPYQTGKNIAAGINEGRIRMGDKHLSLFAQDLGYGFYTKDTPSGKLDLAIIEVSAITEDGGLVPTSS
GGVIPEILMMCDHVIVEVNVGQPSFEGMHDNIICDNPPNRQVLNITRADSRIGTTAVPCDPSKIIAVVESEYRDNGRAFS
EQDETSEAIANHIIDFFSHEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSDLSVYTEVLQDTMLDLIDSGKLNCAS
SCSLSLSKDEGFPRFFANMDKYANKILLRPLSISNAPEPIRRLGVIAMNTPVEIDIYAHANSTLVGGTRMINGIGGSGDF
LRNGYLKIMHTPSSRPTKTDPTGITCVVPHCSHIDHTEHDLDCVVTEQGLADLRGLAPKERARRIIEKCAHPDYKPILFA
YLEIATKECMARKVGHEPQVWDRAFKMQLNLAQNGTMKIKNWDMKIDLCE

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=501, Percent_Identity=41.9161676646707, Blast_Score=378, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17538151, Length=233, Percent_Identity=27.0386266094421, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319456, Length=519, Percent_Identity=57.4181117533719, Blast_Score=603, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 58265; Mature: 58134

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYGTLQERVRCTSLLGKVMKAEETIPFFKNGMNLGWSGFTPAGYPKAVPIALADHVEK
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHC
NNLQGKLRFSIFTGASVGAETEDRWATLDMIDRRWPYQTGKNIAAGINEGRIRMGDKHLS
CCCCEEEEEEEEECCCCCCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHH
LFAQDLGYGFYTKDTPSGKLDLAIIEVSAITEDGGLVPTSSGGVIPEILMMCDHVIVEVN
HHHHHHCCCCEECCCCCCCEEEEEEEEEEEECCCCEEECCCCCHHHHHHHHHCEEEEEEE
VGQPSFEGMHDNIICDNPPNRQVLNITRADSRIGTTAVPCDPSKIIAVVESEYRDNGRAF
CCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCEECCCCHHHEEEEEEHHHCCCCCCC
SEQDETSEAIANHIIDFFSHEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSDLSVY
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
TEVLQDTMLDLIDSGKLNCASSCSLSLSKDEGFPRFFANMDKYANKILLRPLSISNAPEP
HHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHH
IRRLGVIAMNTPVEIDIYAHANSTLVGGTRMINGIGGSGDFLRNGYLKIMHTPSSRPTKT
HHHCCEEEECCCEEEEEEEECCCEEECCHHEEECCCCCCCHHHCCEEEEEECCCCCCCCC
DPTGITCVVPHCSHIDHTEHDLDCVVTEQGLADLRGLAPKERARRIIEKCAHPDYKPILF
CCCCEEEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCHHHH
AYLEIATKECMARKVGHEPQVWDRAFKMQLNLAQNGTMKIKNWDMKIDLCE
HHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCEEEEEECCEEEEECC
>Mature Secondary Structure 
AKYGTLQERVRCTSLLGKVMKAEETIPFFKNGMNLGWSGFTPAGYPKAVPIALADHVEK
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHC
NNLQGKLRFSIFTGASVGAETEDRWATLDMIDRRWPYQTGKNIAAGINEGRIRMGDKHLS
CCCCEEEEEEEEECCCCCCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCEEEECHHHHH
LFAQDLGYGFYTKDTPSGKLDLAIIEVSAITEDGGLVPTSSGGVIPEILMMCDHVIVEVN
HHHHHHCCCCEECCCCCCCEEEEEEEEEEEECCCCEEECCCCCHHHHHHHHHCEEEEEEE
VGQPSFEGMHDNIICDNPPNRQVLNITRADSRIGTTAVPCDPSKIIAVVESEYRDNGRAF
CCCCCCCCCCCCEEECCCCCCCEEEEEECCCCCCCEECCCCHHHEEEEEEHHHCCCCCCC
SEQDETSEAIANHIIDFFSHEVKAGRLPKNLLPLQSGVGSIANAVIGGLAKGPFSDLSVY
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
TEVLQDTMLDLIDSGKLNCASSCSLSLSKDEGFPRFFANMDKYANKILLRPLSISNAPEP
HHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCHH
IRRLGVIAMNTPVEIDIYAHANSTLVGGTRMINGIGGSGDFLRNGYLKIMHTPSSRPTKT
HHHCCEEEECCCEEEEEEEECCCEEECCHHEEECCCCCCCHHHCCEEEEEECCCCCCCCC
DPTGITCVVPHCSHIDHTEHDLDCVVTEQGLADLRGLAPKERARRIIEKCAHPDYKPILF
CCCCEEEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCHHHH
AYLEIATKECMARKVGHEPQVWDRAFKMQLNLAQNGTMKIKNWDMKIDLCE
HHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCEEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]