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The map label for this gene is manC [H]

Identifier: 78222322

GI number: 78222322

Start: 1227267

End: 1228340

Strand: Direct

Name: manC [H]

Synonym: Gmet_1104

Alternate gene names: 78222322

Gene position: 1227267-1228340 (Clockwise)

Preceding gene: 78222321

Following gene: 78222323

Centisome position: 30.7

GC content: 65.64

Gene sequence:

>1074_bases
ATGTACGTCGTCATCCTCGCCGGCGGCTCCGGCACCCGTTTCTGGCCCCTGTCCCGCAAACTCCATCCCAAGCAACTCAT
GTCGGTCTTCGGCGGCAAGTCGATGCTCCAGCGAACCGCGGAACGGGTTCTCCCCCTTAACCCCAAGCGAATACTCGTGA
TCACCAACCACCTCCAGGCCGAGGAAACCCGGCGCCAGCTGGAGTATCTGCGGGGCGTCCGGATCGAGGTGATCGAGGAA
CCCCTGGGGCGCAACACGGCCCCCGCCATCTGCCTCGCCGCCACCCTCATTGCCCGCCACGACCCCGAAGCGGTGATGGC
GGTGCTCCCCGCTGACCATTTCATCCGTGACGAGGATGCATTCTGTGCCACCATCCAGAAGGGGAGGGAGGCGGCCCTGA
ACGGCTACCTGGTCACCCTGGGAATCACCCCTGACCGCCCCGAGACCGGTTACGGCTACATCGAGGCCGAGACATCGCTG
CGGGGTGACGGGCCCTACCCGGTAAAGAGGTTCGTGGAAAAGCCCGACCGCGAGAGGGCCCTGGAGTTCCTTGCCGCCGG
CACCTTCTTCTGGAACAGCGGCATGTTCCTCTGGCGTGCCGACGTGATCCTTGGCCAGATGGCAGCCCATATGCCGGAAC
TGGCTCAGGCCTTTGCCGGCATCACCTTTTCCCCCGACATCTGGGAACCGGCCGACCTGGCCCCCCAGATCGAGGCGGTT
TACGCCATGGTCAAAGGGGAGTCCATCGACTATGGCGTCATGGAGAAGGCCGATAGTGTGGCCATGATCCCGGCTTCCTT
CGGGTGGAGCGACGTGGGGAGCTGGAGCGCGCTCCCCGAGGTGATGGAGCCCGACGCGGCCGGCAACGTGGTCATCGGCG
CGCCGGAAACGGTCATTGCCGATGCCGCCGGCTGCATCCTCCGTGGCGAGAAGCTCATGGCACTGGTCGGGGTTCGGGAT
CTCGTGGTGGTCGATACCCCCGACGCCCTCCTGGTCTGCGCCAAGGACAGGGCCCAGGACGTGAAGAAAGTGGTGGAGGA
GCTGGAGCGGCGCGGCCTGAGGCGCTGCCTCTGA

Upstream 100 bases:

>100_bases
AAACCAGGAGTCAGAATTCAGAATGGGTAAACCGCCTGGCTTCTGAATCCTGAATTCTGACTCCTGACTCCTGGATTCTT
AAACTCAGGAGGTTCTCCCC

Downstream 100 bases:

>100_bases
TGAGTTACGAAGTCCTCAAAGATCTGGAGATCCTGTTCGGCCTGGCCGTGTTCACGGTGGTGCTCCTGCGCCGGTTCATG
CTCCCCTCCATCATTGGCTT

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MYVVILAGGSGTRFWPLSRKLHPKQLMSVFGGKSMLQRTAERVLPLNPKRILVITNHLQAEETRRQLEYLRGVRIEVIEE
PLGRNTAPAICLAATLIARHDPEAVMAVLPADHFIRDEDAFCATIQKGREAALNGYLVTLGITPDRPETGYGYIEAETSL
RGDGPYPVKRFVEKPDRERALEFLAAGTFFWNSGMFLWRADVILGQMAAHMPELAQAFAGITFSPDIWEPADLAPQIEAV
YAMVKGESIDYGVMEKADSVAMIPASFGWSDVGSWSALPEVMEPDAAGNVVIGAPETVIADAAGCILRGEKLMALVGVRD
LVVVDTPDALLVCAKDRAQDVKKVVEELERRGLRRCL

Sequences:

>Translated_357_residues
MYVVILAGGSGTRFWPLSRKLHPKQLMSVFGGKSMLQRTAERVLPLNPKRILVITNHLQAEETRRQLEYLRGVRIEVIEE
PLGRNTAPAICLAATLIARHDPEAVMAVLPADHFIRDEDAFCATIQKGREAALNGYLVTLGITPDRPETGYGYIEAETSL
RGDGPYPVKRFVEKPDRERALEFLAAGTFFWNSGMFLWRADVILGQMAAHMPELAQAFAGITFSPDIWEPADLAPQIEAV
YAMVKGESIDYGVMEKADSVAMIPASFGWSDVGSWSALPEVMEPDAAGNVVIGAPETVIADAAGCILRGEKLMALVGVRD
LVVVDTPDALLVCAKDRAQDVKKVVEELERRGLRRCL
>Mature_357_residues
MYVVILAGGSGTRFWPLSRKLHPKQLMSVFGGKSMLQRTAERVLPLNPKRILVITNHLQAEETRRQLEYLRGVRIEVIEE
PLGRNTAPAICLAATLIARHDPEAVMAVLPADHFIRDEDAFCATIQKGREAALNGYLVTLGITPDRPETGYGYIEAETSL
RGDGPYPVKRFVEKPDRERALEFLAAGTFFWNSGMFLWRADVILGQMAAHMPELAQAFAGITFSPDIWEPADLAPQIEAV
YAMVKGESIDYGVMEKADSVAMIPASFGWSDVGSWSALPEVMEPDAAGNVVIGAPETVIADAAGCILRGEKLMALVGVRD
LVVVDTPDALLVCAKDRAQDVKKVVEELERRGLRRCL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=360, Percent_Identity=41.9444444444444, Blast_Score=238, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 39201; Mature: 39201

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00559 MOLYBDOPTERIN_EUK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVILAGGSGTRFWPLSRKLHPKQLMSVFGGKSMLQRTAERVLPLNPKRILVITNHLQA
CEEEEEECCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCH
EETRRQLEYLRGVRIEVIEEPLGRNTAPAICLAATLIARHDPEAVMAVLPADHFIRDEDA
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEECCHHHCCCCCH
FCATIQKGREAALNGYLVTLGITPDRPETGYGYIEAETSLRGDGPYPVKRFVEKPDRERA
HHHHHHHCHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCHHHH
LEFLAAGTFFWNSGMFLWRADVILGQMAAHMPELAQAFAGITFSPDIWEPADLAPQIEAV
HHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
YAMVKGESIDYGVMEKADSVAMIPASFGWSDVGSWSALPEVMEPDAAGNVVIGAPETVIA
HHHHCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCEEECCCHHHHH
DAAGCILRGEKLMALVGVRDLVVVDTPDALLVCAKDRAQDVKKVVEELERRGLRRCL
HCCHHHEECCHHHEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYVVILAGGSGTRFWPLSRKLHPKQLMSVFGGKSMLQRTAERVLPLNPKRILVITNHLQA
CEEEEEECCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCH
EETRRQLEYLRGVRIEVIEEPLGRNTAPAICLAATLIARHDPEAVMAVLPADHFIRDEDA
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHEEEECCHHHCCCCCH
FCATIQKGREAALNGYLVTLGITPDRPETGYGYIEAETSLRGDGPYPVKRFVEKPDRERA
HHHHHHHCHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCHHHH
LEFLAAGTFFWNSGMFLWRADVILGQMAAHMPELAQAFAGITFSPDIWEPADLAPQIEAV
HHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
YAMVKGESIDYGVMEKADSVAMIPASFGWSDVGSWSALPEVMEPDAAGNVVIGAPETVIA
HHHHCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCEEECCCHHHHH
DAAGCILRGEKLMALVGVRDLVVVDTPDALLVCAKDRAQDVKKVVEELERRGLRRCL
HCCHHHEECCHHHEEECCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]