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The map label for this gene is fmt

Identifier: 78188465

GI number: 78188465

Start: 568475

End: 569419

Strand: Reverse

Name: fmt

Synonym: Cag_0487

Alternate gene names: 78188465

Gene position: 569419-568475 (Counterclockwise)

Preceding gene: 78188466

Following gene: 78188462

Centisome position: 22.14

GC content: 51.22

Gene sequence:

>945_bases
ATGCGAATTATTGTTATGGGCACCCCCGATTTTGCTGTGCCATCGCTACAAGCAATTGCCGCAATGGGCAACGGCTTTGA
TATTGTGCTGGTGGTTACAGGGCAGGACAAACCACGCAAAAGCAAACATGCGGCGGCTGAAGCCTCCCCTATCAAACAAG
CCGCATTAGCACTAAACTTGCCCGTGCATGAAGTGGATGATGTAAACGATCCCCACTTTGCTGAAATTGTTGCCGCTTAC
AAACCTGACGTTATTGTTGTTGCCGCTTTCCGCATTTTACCGCCAGCCGTCTATAGCCAAGCACGCCTTGGAGCATTTAA
CCTCCACGCATCCCTTCTCCCCGCCTATCGAGGCGCTGCACCCGTAAATTGGGCAATTATGAATGGTGAAGAGGAAACAG
GTGTTACCACCTTTTTTTTGCAACAGCGGGTGGATACTGGCACCATTATTATGCAGCAAAAAACAGCAATTGCGCCCGAA
GAGAATGCCACCGAATTAATAGTACGCCTTGCGAACATTGGTGCTGACGTAGTGGTGGAAACCTTGCGCCGCATTGCAGC
CAAAAACGCTGCCACTGCCCCGCAAGATGATTCACTTGCCTCCCGTGCCCCTAAGCTAACCCGTATCAACACCCGCATTA
ATTGGGAACAACCCGTTGCCACTCTCCACAACTTTATTCGTGGTTTAGCGCTCAAACCCTCCGCATGGACAACGTTTAAC
GATAAAACGCTCAAAATCTTCCGTACTACATTAAGCACACCCGAGCACGACCACCCTTCGGCACCAGCAGGGAGCTTGCT
GGTAAGCCACGGAAAACTGTACGTTCACGGCAGTGATGGATGGCTTGAGCTTCTTGCATTGCAGCTTGAAGGACGCAAGC
CAATGGAGGCGGCTGATTTTGCGCGTGGGCTTCATGTTGAAGGCGAAGCGCTGAGGTTGGTATGA

Upstream 100 bases:

>100_bases
GCAGAATAAAACCATTGCTCAATTGATTACAAGAGGCAATGAATGATTGATGAATCGGCAGAGCAGCAGGATGAGTACTC
TGCACATGAAGAGAGGAACT

Downstream 100 bases:

>100_bases
GTGACTGAGAGGTTGGTTGCAACAATCGCTCTTACATAAAAGTGATACATTTTAATGCAGCAAATGCAAGAAAGTGGTAC
ATTTGGCTGCTAATCACTCA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRIIVMGTPDFAVPSLQAIAAMGNGFDIVLVVTGQDKPRKSKHAAAEASPIKQAALALNLPVHEVDDVNDPHFAEIVAAY
KPDVIVVAAFRILPPAVYSQARLGAFNLHASLLPAYRGAAPVNWAIMNGEEETGVTTFFLQQRVDTGTIIMQQKTAIAPE
ENATELIVRLANIGADVVVETLRRIAAKNAATAPQDDSLASRAPKLTRINTRINWEQPVATLHNFIRGLALKPSAWTTFN
DKTLKIFRTTLSTPEHDHPSAPAGSLLVSHGKLYVHGSDGWLELLALQLEGRKPMEAADFARGLHVEGEALRLV

Sequences:

>Translated_314_residues
MRIIVMGTPDFAVPSLQAIAAMGNGFDIVLVVTGQDKPRKSKHAAAEASPIKQAALALNLPVHEVDDVNDPHFAEIVAAY
KPDVIVVAAFRILPPAVYSQARLGAFNLHASLLPAYRGAAPVNWAIMNGEEETGVTTFFLQQRVDTGTIIMQQKTAIAPE
ENATELIVRLANIGADVVVETLRRIAAKNAATAPQDDSLASRAPKLTRINTRINWEQPVATLHNFIRGLALKPSAWTTFN
DKTLKIFRTTLSTPEHDHPSAPAGSLLVSHGKLYVHGSDGWLELLALQLEGRKPMEAADFARGLHVEGEALRLV
>Mature_314_residues
MRIIVMGTPDFAVPSLQAIAAMGNGFDIVLVVTGQDKPRKSKHAAAEASPIKQAALALNLPVHEVDDVNDPHFAEIVAAY
KPDVIVVAAFRILPPAVYSQARLGAFNLHASLLPAYRGAAPVNWAIMNGEEETGVTTFFLQQRVDTGTIIMQQKTAIAPE
ENATELIVRLANIGADVVVETLRRIAAKNAATAPQDDSLASRAPKLTRINTRINWEQPVATLHNFIRGLALKPSAWTTFN
DKTLKIFRTTLSTPEHDHPSAPAGSLLVSHGKLYVHGSDGWLELLALQLEGRKPMEAADFARGLHVEGEALRLV

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=221, Percent_Identity=31.2217194570136, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI164663775, Length=321, Percent_Identity=28.6604361370716, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI238814322, Length=292, Percent_Identity=28.7671232876712, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789683, Length=301, Percent_Identity=33.5548172757475, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788589, Length=314, Percent_Identity=30.8917197452229, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1788846, Length=123, Percent_Identity=31.7073170731707, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI133930964, Length=320, Percent_Identity=26.875, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550868, Length=318, Percent_Identity=32.0754716981132, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28571984, Length=235, Percent_Identity=34.0425531914894, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24585660, Length=308, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_CHLCH (Q3ATB5)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378803.1
- HSSP:   P77398
- ProteinModelPortal:   Q3ATB5
- SMR:   Q3ATB5
- STRING:   Q3ATB5
- GeneID:   3746356
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0487
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- ProtClustDB:   CLSK637772
- BioCyc:   CCHL340177:CAG_0487-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33971; Mature: 33971

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIVMGTPDFAVPSLQAIAAMGNGFDIVLVVTGQDKPRKSKHAAAEASPIKQAALALNL
CEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCHHHHHHEEECC
PVHEVDDVNDPHFAEIVAAYKPDVIVVAAFRILPPAVYSQARLGAFNLHASLLPAYRGAA
CCHHCCCCCCCHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHCCEEEHHHHHHHHHCCCC
PVNWAIMNGEEETGVTTFFLQQRVDTGTIIMQQKTAIAPEENATELIVRLANIGADVVVE
CCEEEEECCCCCCCCEEEEEHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHH
TLRRIAAKNAATAPQDDSLASRAPKLTRINTRINWEQPVATLHNFIRGLALKPSAWTTFN
HHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEC
DKTLKIFRTTLSTPEHDHPSAPAGSLLVSHGKLYVHGSDGWLELLALQLEGRKPMEAADF
CCEEEEEEECCCCCCCCCCCCCCCCEEEECCEEEEECCCCCEEEEEEEECCCCCCCHHHH
ARGLHVEGEALRLV
HCCCCCCCCEEECC
>Mature Secondary Structure
MRIIVMGTPDFAVPSLQAIAAMGNGFDIVLVVTGQDKPRKSKHAAAEASPIKQAALALNL
CEEEEEECCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCHHHHHHEEECC
PVHEVDDVNDPHFAEIVAAYKPDVIVVAAFRILPPAVYSQARLGAFNLHASLLPAYRGAA
CCHHCCCCCCCHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHCCEEEHHHHHHHHHCCCC
PVNWAIMNGEEETGVTTFFLQQRVDTGTIIMQQKTAIAPEENATELIVRLANIGADVVVE
CCEEEEECCCCCCCCEEEEEHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHH
TLRRIAAKNAATAPQDDSLASRAPKLTRINTRINWEQPVATLHNFIRGLALKPSAWTTFN
HHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEC
DKTLKIFRTTLSTPEHDHPSAPAGSLLVSHGKLYVHGSDGWLELLALQLEGRKPMEAADF
CCEEEEEEECCCCCCCCCCCCCCCCEEEECCEEEEECCCCCEEEEEEEECCCCCCCHHHH
ARGLHVEGEALRLV
HCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA