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The map label for this gene is folK [H]

Identifier: 78188213

GI number: 78188213

Start: 263926

End: 264432

Strand: Reverse

Name: folK [H]

Synonym: Cag_0230

Alternate gene names: 78188213

Gene position: 264432-263926 (Counterclockwise)

Preceding gene: 78188214

Following gene: 78188208

Centisome position: 10.28

GC content: 48.32

Gene sequence:

>507_bases
ATGCAGCAACACACCGTTTACATTGGCATAGGCTCCAATATTGGCGATAGAATGAGCCACTTGCGTGAAGCTCTTGCCAT
GCTCAATAATCTTGAAAGCACCTCTGTAACCGCTATTTCCGCTATTTACATGACGGAGCCTGTTGGCGAAATCAATCAAG
AGCGCTTTTACAACGGCGTGCTTGCCGTAACAACCTCCATGCAACCTGAAGCATTACGCCAAGAATGTAAAGCTATTGAG
CGCACCATTGGGCGTCCTGCAACCTATCAGCGCTGGAGCCCTCGTGTTATTGATTTGGACTTGCTGCTTTTTGACACGCT
TGTGTGCCAAACCGACACACTTGCCATTCCCCACCCCGAACTGCACCACCGCAACTTTGTGCTCATTCCGTTACTAGATA
TTGCCAATCCTACCCATCCATTGCTTGGCAAAAGTATTCGTGAACTGCTCGCCTTGTGCCCCGATCGCTCGGTACTTATT
AAGTTACAAGAGAACATAGCGTTGTAA

Upstream 100 bases:

>100_bases
AATTGCCAACCATAGAACAACTAGAAAACCAACTCAATACCTATCAACAATGACCCTGCCCCCCATTGAAAGCGTTGTTA
ATATTCAAGCAATATAAAAT

Downstream 100 bases:

>100_bases
GATACATTGCATCGTATATACCCGATGGCGAACAAAACATTTTCCCCATAAAAACCAAAAACCCTCTGGATTGCAGAGGG
TTTTTAAGTTTAGATGTTGC

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MQQHTVYIGIGSNIGDRMSHLREALAMLNNLESTSVTAISAIYMTEPVGEINQERFYNGVLAVTTSMQPEALRQECKAIE
RTIGRPATYQRWSPRVIDLDLLLFDTLVCQTDTLAIPHPELHHRNFVLIPLLDIANPTHPLLGKSIRELLALCPDRSVLI
KLQENIAL

Sequences:

>Translated_168_residues
MQQHTVYIGIGSNIGDRMSHLREALAMLNNLESTSVTAISAIYMTEPVGEINQERFYNGVLAVTTSMQPEALRQECKAIE
RTIGRPATYQRWSPRVIDLDLLLFDTLVCQTDTLAIPHPELHHRNFVLIPLLDIANPTHPLLGKSIRELLALCPDRSVLI
KLQENIAL
>Mature_168_residues
MQQHTVYIGIGSNIGDRMSHLREALAMLNNLESTSVTAISAIYMTEPVGEINQERFYNGVLAVTTSMQPEALRQECKAIE
RTIGRPATYQRWSPRVIDLDLLLFDTLVCQTDTLAIPHPELHHRNFVLIPLLDIANPTHPLLGKSIRELLALCPDRSVLI
KLQENIAL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=130, Percent_Identity=36.1538461538462, Blast_Score=100, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=139, Percent_Identity=36.6906474820144, Blast_Score=91, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18879; Mature: 18879

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQHTVYIGIGSNIGDRMSHLREALAMLNNLESTSVTAISAIYMTEPVGEINQERFYNGV
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCE
LAVTTSMQPEALRQECKAIERTIGRPATYQRWSPRVIDLDLLLFDTLVCQTDTLAIPHPE
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEECCCCC
LHHRNFVLIPLLDIANPTHPLLGKSIRELLALCPDRSVLIKLQENIAL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEECCCCC
>Mature Secondary Structure
MQQHTVYIGIGSNIGDRMSHLREALAMLNNLESTSVTAISAIYMTEPVGEINQERFYNGV
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCE
LAVTTSMQPEALRQECKAIERTIGRPATYQRWSPRVIDLDLLLFDTLVCQTDTLAIPHPE
EEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEECCCCC
LHHRNFVLIPLLDIANPTHPLLGKSIRELLALCPDRSVLIKLQENIAL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]