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The map label for this gene is ndk

Identifier: 78188187

GI number: 78188187

Start: 232987

End: 233409

Strand: Reverse

Name: ndk

Synonym: Cag_0204

Alternate gene names: 78188187

Gene position: 233409-232987 (Counterclockwise)

Preceding gene: 78188188

Following gene: 78188179

Centisome position: 9.07

GC content: 45.15

Gene sequence:

>423_bases
ATGGAAAGAACGCTAACCATTTTGAAACCCGATTGTGTGCGTAAGCAACTTATCGGCGCTGTTATTAACCACATTGAGCG
CGCTGGTTTTCGCGTTGTGGCTATGAAGAAAATCCATTTAACAAAAGAAGCGGCTGGTGAGTTTTACGCTGTTCACCGTG
AGCGCCCATTTTATGGTGAGTTAGTTGATTTTATGTCATCGGGGGCTTGCGTTCCAATGATTCTTGAAAAAGAGAATGCG
GTTGCTGATTTCCGCACGGTTATTGGTGCTACCGATCCTGCTGAGGCGGCTGAGGGCACGGTGCGTAAGCTTTATGCTGA
TAGCAAGGGTGAAAATATTATTCACGGTTCTGATTCTGTTGAAAATGCGGCTATTGAAGCGGCGTTCTTCTTTTCAACTG
AAGAAGTGGTAAGAAGCAACTAA

Upstream 100 bases:

>100_bases
AATTCTTCTCCCTTGCTCCCCCCCATTTCCATTATCTCCCGTCATTGCGTATCTTCCCGCCCCATTGTTTTTTGTAATTC
AAACTCGTACAACTACCTCC

Downstream 100 bases:

>100_bases
GTTCTTCCCTTTCTTGATGGTTCTCTCTATCCCCCTTAAAAAAAGCGGCTCGTAACAGTGCCGCTTTTTTGTTGTATGAC
GGCAAAGCTGGTGCGCTTAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MERTLTILKPDCVRKQLIGAVINHIERAGFRVVAMKKIHLTKEAAGEFYAVHRERPFYGELVDFMSSGACVPMILEKENA
VADFRTVIGATDPAEAAEGTVRKLYADSKGENIIHGSDSVENAAIEAAFFFSTEEVVRSN

Sequences:

>Translated_140_residues
MERTLTILKPDCVRKQLIGAVINHIERAGFRVVAMKKIHLTKEAAGEFYAVHRERPFYGELVDFMSSGACVPMILEKENA
VADFRTVIGATDPAEAAEGTVRKLYADSKGENIIHGSDSVENAAIEAAFFFSTEEVVRSN
>Mature_140_residues
MERTLTILKPDCVRKQLIGAVINHIERAGFRVVAMKKIHLTKEAAGEFYAVHRERPFYGELVDFMSSGACVPMILEKENA
VADFRTVIGATDPAEAAEGTVRKLYADSKGENIIHGSDSVENAAIEAAFFFSTEEVVRSN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.8529411764706, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=41.6058394160584, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=41.6058394160584, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=41.6058394160584, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=41.6058394160584, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=41.6058394160584, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=44.1176470588235, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.1764705882353, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.1764705882353, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=31.1111111111111, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=31.1111111111111, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.037037037037, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI148839372, Length=139, Percent_Identity=33.0935251798561, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=31.8518518518519, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=52.2058823529412, Blast_Score=137, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=37.037037037037, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=36.0294117647059, Blast_Score=105, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=43.3823529411765, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645457, Length=140, Percent_Identity=32.8571428571429, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CHLCH (Q3AU43)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378525.1
- ProteinModelPortal:   Q3AU43
- SMR:   Q3AU43
- STRING:   Q3AU43
- GeneID:   3746691
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0204
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK14541
- BioCyc:   CCHL340177:CAG_0204-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15433; Mature: 15433

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTLTILKPDCVRKQLIGAVINHIERAGFRVVAMKKIHLTKEAAGEFYAVHRERPFYGE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHH
LVDFMSSGACVPMILEKENAVADFRTVIGATDPAEAAEGTVRKLYADSKGENIIHGSDSV
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
ENAAIEAAFFFSTEEVVRSN
CHHHHHHHHEECHHHHHHCC
>Mature Secondary Structure
MERTLTILKPDCVRKQLIGAVINHIERAGFRVVAMKKIHLTKEAAGEFYAVHRERPFYGE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHH
LVDFMSSGACVPMILEKENAVADFRTVIGATDPAEAAEGTVRKLYADSKGENIIHGSDSV
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
ENAAIEAAFFFSTEEVVRSN
CHHHHHHHHEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA