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The map label for this gene is lpxH [H]

Identifier: 78066857

GI number: 78066857

Start: 2454155

End: 2454955

Strand: Direct

Name: lpxH [H]

Synonym: Bcep18194_A5388

Alternate gene names: 78066857

Gene position: 2454155-2454955 (Clockwise)

Preceding gene: 78066856

Following gene: 78066860

Centisome position: 66.43

GC content: 66.54

Gene sequence:

>801_bases
ATGTTGCAGGAGAGTCCGCCGCGAAGCGTCTCCGCGGGCGTGCCGGGCGAGCGCGAATACGCGCAAGCCGCACGCCCGTT
CCTGTTTCTCTCCGATCTGCACCTGAGCGAAGCGATTCCGAAGACGGTCGCCGCGTTCGAGCATTTCGTGAAATACACCG
CCGACAGCGCCGACTCGGTGTTCATCCTCGGCGACCTGTTCGAATACTGGATCGGCGACGATATCCTCGACGACGATCCG
TTCGCGGCCCGCATGGCCGCGCTGATGCACACGTTCTCGGAGCGCGGCATTGCGCTCTACGTGATGCACGGCAACCGCGA
TTTCCTGCTCGGCCGGCGCTTCATGAAGGCAGCCGGCGCGATGCTGCTACCCGACCCTTCGCTGATCATGGCGTTCGGCC
AGCGCATCGTGCTCGCGCACGGCGACGCGCAATGCACGGCCGACCGCGGCTACCAGTTGTTCCGCCGCTTCGCACGCAAC
CGCGTCGCGCAATGGCTGTTTCTCGCGTGGCCGTTCCGCTGGCGCCGCGCACTCGCGCAACGCATGCGCTCGAACAGCGA
AGCAGGCCGGATGCGACCTGCTTCGGCGATTTACGATGTCACGCGTGAAGGCGTGGCCGCGCTGTTCCGGAAAAGCCGTG
CGAGCGTGATCATTCACGGCCATACGCACCGCCCCGCGCGGCACATGGAACCGGGCGGCATCCGCTGGGTGTTGCCCGAC
TGGGATCTCGACCACGGCAAGCCGCGCGGCGGCTACCTGCGCGTCGATGCGGAAGGCATCCACGCGATGCCGCTGGACTG
A

Upstream 100 bases:

>100_bases
CAAGACGGGCAACGCTGGTTTCCACCAGGACGTGCCGGCTGACGACGTCGTGATCGAGAAGGCCGTCGTGGTCTGACGCG
CAGTATACGGAGGCACTTCG

Downstream 100 bases:

>100_bases
CACCGCCGCTGCCTGCGCACCGGCCGGCAGCCGCCGGCCTCCATCGCATTACGCCTGGCGTTCGACCGACTTGCCTTCCA
GCACGGCCGACAGCCGGCGC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MLQESPPRSVSAGVPGEREYAQAARPFLFLSDLHLSEAIPKTVAAFEHFVKYTADSADSVFILGDLFEYWIGDDILDDDP
FAARMAALMHTFSERGIALYVMHGNRDFLLGRRFMKAAGAMLLPDPSLIMAFGQRIVLAHGDAQCTADRGYQLFRRFARN
RVAQWLFLAWPFRWRRALAQRMRSNSEAGRMRPASAIYDVTREGVAALFRKSRASVIIHGHTHRPARHMEPGGIRWVLPD
WDLDHGKPRGGYLRVDAEGIHAMPLD

Sequences:

>Translated_266_residues
MLQESPPRSVSAGVPGEREYAQAARPFLFLSDLHLSEAIPKTVAAFEHFVKYTADSADSVFILGDLFEYWIGDDILDDDP
FAARMAALMHTFSERGIALYVMHGNRDFLLGRRFMKAAGAMLLPDPSLIMAFGQRIVLAHGDAQCTADRGYQLFRRFARN
RVAQWLFLAWPFRWRRALAQRMRSNSEAGRMRPASAIYDVTREGVAALFRKSRASVIIHGHTHRPARHMEPGGIRWVLPD
WDLDHGKPRGGYLRVDAEGIHAMPLD
>Mature_266_residues
MLQESPPRSVSAGVPGEREYAQAARPFLFLSDLHLSEAIPKTVAAFEHFVKYTADSADSVFILGDLFEYWIGDDILDDDP
FAARMAALMHTFSERGIALYVMHGNRDFLLGRRFMKAAGAMLLPDPSLIMAFGQRIVLAHGDAQCTADRGYQLFRRFARN
RVAQWLFLAWPFRWRRALAQRMRSNSEAGRMRPASAIYDVTREGVAALFRKSRASVIIHGHTHRPARHMEPGGIRWVLPD
WDLDHGKPRGGYLRVDAEGIHAMPLD

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=237, Percent_Identity=40.9282700421941, Blast_Score=179, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 30091; Mature: 30091

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQESPPRSVSAGVPGEREYAQAARPFLFLSDLHLSEAIPKTVAAFEHFVKYTADSADSV
CCCCCCCCCCCCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FILGDLFEYWIGDDILDDDPFAARMAALMHTFSERGIALYVMHGNRDFLLGRRFMKAAGA
EEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCC
MLLPDPSLIMAFGQRIVLAHGDAQCTADRGYQLFRRFARNRVAQWLFLAWPFRWRRALAQ
EECCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RMRSNSEAGRMRPASAIYDVTREGVAALFRKSRASVIIHGHTHRPARHMEPGGIRWVLPD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCC
WDLDHGKPRGGYLRVDAEGIHAMPLD
CCCCCCCCCCCEEEEECCCCEECCCC
>Mature Secondary Structure
MLQESPPRSVSAGVPGEREYAQAARPFLFLSDLHLSEAIPKTVAAFEHFVKYTADSADSV
CCCCCCCCCCCCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FILGDLFEYWIGDDILDDDPFAARMAALMHTFSERGIALYVMHGNRDFLLGRRFMKAAGA
EEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCC
MLLPDPSLIMAFGQRIVLAHGDAQCTADRGYQLFRRFARNRVAQWLFLAWPFRWRRALAQ
EECCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RMRSNSEAGRMRPASAIYDVTREGVAALFRKSRASVIIHGHTHRPARHMEPGGIRWVLPD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCC
WDLDHGKPRGGYLRVDAEGIHAMPLD
CCCCCCCCCCCEEEEECCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]