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The map label for this gene is lon [H]

Identifier: 78066691

GI number: 78066691

Start: 2275597

End: 2278020

Strand: Reverse

Name: lon [H]

Synonym: Bcep18194_A5222

Alternate gene names: 78066691

Gene position: 2278020-2275597 (Counterclockwise)

Preceding gene: 78066692

Following gene: 78066690

Centisome position: 61.67

GC content: 62.91

Gene sequence:

>2424_bases
ATGTCAGGCACCCAACTTCTCCCGCCGGAACGCATCACGCTCCCGCTGCTGCCGCTGCGGGATGTCGTCGTTTTCCCGCA
CATGGTGATTCCGCTCTTCGTGGGCCGGCCGAAATCGATCAAGGCCCTCGAAGCAGCGATGGAAGGCGGCAAGCACATCA
TGCTCGTCGCCCAGAAAACCGCGGCCAAGGACGAACCGACCGAAAAGGACATGTACGAGGTCGGTTGTATCGCCAACATC
CTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTCGTCGAGGGCCTGCAGCGCGCGAAGGCGTTGTCGATCGA
AGAGCAGGAAACGCAATTCTCCTGCGAAGTGATGCCGCTCGAGCCCGATCACGCCGACAGCGCTGAAACGGAAGCGCTGC
GCCGCGCGATCGTGTCGCAGTTCGACCAGTATGTGAAGCTGAACAAGAAGATCCCGCCGGAGATCCTCACGTCGCTGTCG
GGCATCGACGAAGCAGGCCGCCTCGCCGACATGATCGCCGAGCGCCTGCCGCTGAAACTCGACCAGAAGCAGCACATCCT
CGAGATGTTCCCGGTCATCGAGCGCCTCGAGCACCTGCTCGCGCAGCTCGAAGCCGAGATCGACATCCTGCAGGTCGAAA
AGCGCATCCGCGGGCGCGTGAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAACAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAAGGCGAAGAGGGTGCCGATCTCGAGGAACTCGAGAAGCGCATCAACGCTGCGCGCATGCCGAA
GGAAGCGAAGAAGAAGGCCGACGCCGAGCTGAAGAAGCTGAAGCTGATGTCGCCGATGTCGGCGGAAGCCACCGTCGTGC
GCAACTACATCGACACGCTGATCGGCCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTGTCGAACGCCGAGCAG
GTGCTTGACGAGGATCACTTCGGCCTCGAGAAGGTGAAGGAACGGATCCTCGAGTATCTCGCGGTCCAGCAGCGCGTCGA
CAAGGTCAAGGCACCGATCCTGTGCCTCGTCGGGCCTCCGGGCGTCGGCAAGACCTCGCTCGGCCAGTCGATCGCCCGTG
CGACGAACCGCAAGTTCGTCCGGATGGCGCTCGGCGGCGTGCGTGACGAAGCCGAGATCCGCGGCCACCGCCGTACGTAC
ATCGGTTCGATGCCGGGCAAGATCCTGCAGAGCCTCACGAAGGTCGGCGTGCGCAATCCGCTCTTCCTGCTCGACGAAGT
CGACAAGATGGGCATGGATTTCCGCGGCGATCCGTCGTCGGCGCTGCTCGAAGTGCTCGATCCGGAACAGAACCACACGT
TCGCCGACCACTACATCGAAGTCGACTTCGACCTGTCGGACGTGATGTTCGTCGCGACGTCGAACTCGCTGAACATCCCG
CCGCCGCTGCTCGACCGGATGGAAGTGATCCGTCTGTCGGGTTACACGGAAGACGAGAAGGTCAGCATCGCCCAGCGTTA
CCTGCTGCCGAAGCAGAAGAAGAACAACGGGCTGAAGGAAGGCGAGATCGAGGTCACCGAGCAGGCGATCCGCGACATCA
TCCGCTACTACACGCGTGAAGCCGGTGTGCGTTCGCTCGAGCGGGAAGTGTCGAAGATCTGCCGCAAGGTCGTGAAGATG
TTGCTGCTGAAGAAGGCATCGGGCGCGATCAAGGTCGACGGCGAAAACCTCGACACGTTCCTCGGCGTGCGCAAGTACGA
CTTCGGCCTCGCGGCGAAGGAAAACCAGGTCGGTCAGGTGACGGGCCTCGCGTGGACGGAAGTCGGTGGCGATCTGCTGA
CGATCGAAGCCGCGGTGATGCCGGGCAAGGGCAACGTGATCCGTACGGGTTCGCTCGGCGACGTGATGAAGGAGTCGGTC
GAGGCGGCACGTTCGGTCGTGCGCTCGCGTTCGCGTCGTCTCGGCATCAAGGACGAAGCGTTCGAGAAGCAGGACATCCA
CATCCACGTGCCGGAAGGCGCGACGCCGAAGGACGGTCCGTCTGCCGGTGGTGCGATGACGACCGCGCTGGTATCGGTGC
TGACGGGTATCCCCGTGCGTGCCGATGTCGCGATGACGGGCGAAATCACGCTGCGTGGTGAAGTCCTGCCGATCGGCGGC
CTGAAGGAGAAGCTGCTCGCAGCGCATCGCGGTGGCATCAAGCTCGTGCTGATCCCGGAAGAGAACGTGAAGGATCTCGC
CGAGATTCCGGACAACGTGAAGAACGCGATCGAGATCGTGCCGGTCCGCTGGATCGACAAGGTGCTGGAACTCGCGCTCG
AGCGTTCGCCGACCCCGCTGCCGCCGGAAGAAGAGGCGAAGGCGGCGGCACCGGTCGCCGATGCGGCGAAGGATGCCGGC
TCGACGGAATTCGTCAAGCACTAA

Upstream 100 bases:

>100_bases
TGGTTACTTTCTTACCGAATATTTCCCGCACTTGAAGGCTTGCAATTCGTTGTGGCGGCCTCAATTACCGAACAATTGAT
TCCACTCATGGGGAAATGAA

Downstream 100 bases:

>100_bases
GCATCGGAACACCGTCCTTCCTGACGGTTGTTCACGAAACCCGCGGCATGGCCGCGGGTTTTTTTATGCGTCTTGAAATC
GTGCGCGCGAGTGTTAAAAA

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERSPTPLPPEEEAKAAAPVADAAKDAG
STEFVKH

Sequences:

>Translated_807_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERSPTPLPPEEEAKAAAPVADAAKDAG
STEFVKH
>Mature_806_residues
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANIL
QMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQV
LDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKML
LLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERSPTPLPPEEEAKAAAPVADAAKDAGS
TEFVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=568, Percent_Identity=46.4788732394366, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=684, Percent_Identity=40.4970760233918, Blast_Score=504, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=69.8701298701299, Blast_Score=1080, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.4508670520231, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=41.4814814814815, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=40.4166666666667, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=671, Percent_Identity=41.7287630402384, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24666867, Length=671, Percent_Identity=41.7287630402384, Blast_Score=509, Evalue=1e-144,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89372; Mature: 89241

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADMIAERLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERSPTPL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHCCCCCC
PPEEEAKAAAPVADAAKDAGSTEFVKH
CCCHHHHHHCCHHHHHHCCCCCHHHCC
>Mature Secondary Structure 
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADMIAERLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGENLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERSPTPL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHCCCCCC
PPEEEAKAAAPVADAAKDAGSTEFVKH
CCCHHHHHHCCHHHHHHCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]