Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 78066624

GI number: 78066624

Start: 2201105

End: 2202433

Strand: Reverse

Name: hom [H]

Synonym: Bcep18194_A5155

Alternate gene names: 78066624

Gene position: 2202433-2201105 (Counterclockwise)

Preceding gene: 78066625

Following gene: 78066623

Centisome position: 59.62

GC content: 66.82

Gene sequence:

>1329_bases
ATGGAACCGATCAAAGTTGGCCTGTTGGGCTTCGGCACGGTGGGCAGCGGCACCTTCACGGTGCTGGGCCGCAACCAGGA
AGAAATCAAGCGACGCGCGGGGCGCGGCATCGAGGTGACGCGCATTGCGGTGCGCAACCCGGCCAAGGCGCTGGCTGCGC
TCGGCGGCGACGCCGGCGCCGCGCAAATCACCGACGATTTCAACGCAGTCGTCGATGATCCGTCGATCGCGATCATCGCC
GAGATGATTGGCGGCACGGGCATCGCACGCGAGCTCGTGCTGCGCGCGATCGCGAACGGCAAGCACGTCGTGACGGCCAA
CAAGGCGCTGCTCGCGGTGCACGGCACCGAGATCTTCGAGGCCGCGCGCGCGAAGGGCGTGATGGTCGCGTTCGAGGCGG
CCGTCGCCGGCGGCATCCCGATCATCAAGGCGCTGCGCGAAGGCCTGACCGCGAACCGCATCCAGTACATCGCGGGCATC
ATCAACGGCACGACCAACTACATCCTGTCGGAAATGCGCGATCGCGGGCTCGACTTCGCGACCGCGCTGAAGGCCGCGCA
GGAGCTCGGCTACGCGGAAGCCGATCCGACCTTCGACATCGAAGGCGTCGACGCCGCGCACAAGGCGACGATCATGAGCG
CGATCGCGTTCGGCGTGCCGGTGCAGTTCGAGCGCGCGTACGTCGAGGGCATCAGCAAGCTGGATGCGACCGACATTCGC
TACGCGGAAGAACTCGGCTACCGGATCAAGCTGCTCGGCATCACGCGCCGCGCCGAAAACGGCATCGAGCTGCGCGTGCA
TCCGACGCTGATCCCGGAGAAGCGCCTGCTCGCGAACGTCGAGGGCGCGATGAACGCGGTCGTCGTGCACGGCGACGCGG
TCGGCACGACGCTGTACTACGGCAAGGGCGCGGGCGCGGAGCCGACCGCATCGGCCGTGGTCGCGGATCTCGTCGACGTC
ACGCGCCTGCACACGGCGGACCCGGAGCATCGCGTGCCGCACCTCGCGTTCCAGCCGGACAGCCTGTCGAACACGCCGAT
CCTGCCGATCGAGGAAGTGACGAGCGGCTACTACCTGCGCCTGCGCGTCGCCGATCAAACCGGCGTGCTGGCCGACATCA
CGCGCATCCTCGCCGCATCGGGTATCTCGATCGACGCGCTGCTGCAGAAGGAATCGGAGCAGGTCGACGACGCGAAGGGC
GAAACCGACATCATCCTGATCACGCACGTCACGGTCGAGAAGAACGTGAATGCGGCGATCGCGCAGATCGAGAGCCTTGC
GACGGTGGTATCGAAGGTGACGAAGCTGCGCATGGAAGCGCTGAACTGA

Upstream 100 bases:

>100_bases
CGGATCGCACGTTTCCTCGACGGCTACCGCAAGCGCCATTCGGCCTGAGCGGCAGGGCCACACGGCACTCACTAATTCTT
ACTCATCGATCACACGCAGC

Downstream 100 bases:

>100_bases
GCTGAGGACGACATGAATTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGCCACACGTTCTCCGACATCCTGCTCGG
CGGTCTCGCGAAGGACGGCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEPIKVGLLGFGTVGSGTFTVLGRNQEEIKRRAGRGIEVTRIAVRNPAKALAALGGDAGAAQITDDFNAVVDDPSIAIIA
EMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLDATDIR
YAEELGYRIKLLGITRRAENGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAASGISIDALLQKESEQVDDAKG
ETDIILITHVTVEKNVNAAIAQIESLATVVSKVTKLRMEALN

Sequences:

>Translated_442_residues
MEPIKVGLLGFGTVGSGTFTVLGRNQEEIKRRAGRGIEVTRIAVRNPAKALAALGGDAGAAQITDDFNAVVDDPSIAIIA
EMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLDATDIR
YAEELGYRIKLLGITRRAENGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAASGISIDALLQKESEQVDDAKG
ETDIILITHVTVEKNVNAAIAQIESLATVVSKVTKLRMEALN
>Mature_442_residues
MEPIKVGLLGFGTVGSGTFTVLGRNQEEIKRRAGRGIEVTRIAVRNPAKALAALGGDAGAAQITDDFNAVVDDPSIAIIA
EMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFEAARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLDATDIR
YAEELGYRIKLLGITRRAENGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLADITRILAASGISIDALLQKESEQVDDAKG
ETDIILITHVTVEKNVNAAIAQIESLATVVSKVTKLRMEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=253, Percent_Identity=27.6679841897233, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=140, Percent_Identity=33.5714285714286, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46835; Mature: 46835

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLGRNQEEIKRRAGRGIEVTRIAVRNPAKALAALGGDAGA
CCCEEEEEEEECCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCCC
AQITDDFNAVVDDPSIAIIAEMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFE
CEECCCCHHEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLDATDIR
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHH
YAEELGYRIKLLGITRRAENGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADQTGVLADITRILAASGISIDALLQKESEQVDDAKGETDIILITHVTVEKNVNAAI
EEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHH
AQIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLGRNQEEIKRRAGRGIEVTRIAVRNPAKALAALGGDAGA
CCCEEEEEEEECCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCCC
AQITDDFNAVVDDPSIAIIAEMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFE
CEECCCCHHEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AARAKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLDATDIR
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHH
YAEELGYRIKLLGITRRAENGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADQTGVLADITRILAASGISIDALLQKESEQVDDAKGETDIILITHVTVEKNVNAAI
EEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHH
AQIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]