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The map label for this gene is moeA [H]

Identifier: 78066622

GI number: 78066622

Start: 2198150

End: 2199397

Strand: Reverse

Name: moeA [H]

Synonym: Bcep18194_A5153

Alternate gene names: 78066622

Gene position: 2199397-2198150 (Counterclockwise)

Preceding gene: 78066623

Following gene: 78066621

Centisome position: 59.54

GC content: 71.39

Gene sequence:

>1248_bases
ATGTCGAACCCGAATCCCGCGGCGCCGCGTGCGCCGATGCTGTCGACCGCCGAGGCACTCGCCGCGCTGCTCGATGCCGC
GAAGCCGTTGCCCGGCGCCGAAACCGTCGCCACGCTCGACGCGCTCGGCCGCGTGCTGGCGGCCGACGTGAGCTCGCCGC
TCGACGTGCCGCCGATGCACACGAGCGCGATGGACGGCTATGCGGTGCGCGTCGCCGACCTGCTGCATGGCGACCGGCGT
TTGCCGGTGTCGCAGCGCATTCCGGCCGGTCACCCGGCCGCGCCGCTCGCTGCTGGCACGGCCGCACGGATCTTCACCGG
CGCGACGGTGCCGCCCGGCGCCGACGCCGTCGTGATGCAGGAGCAGACGGCGGCCGACGGCGATGCGGTCGAGATCCTGC
ACACGCCGAAGGCCGGTGAATGGATCACCGCGCAGGGCGCGGATATCCGGCAGGGCTCGGTGATCCTGCCGGCCGGCACG
CGGCTCACGCCGCAGGCGCTCGGCCTGGCCGCGTCGGTCGGCTGCGCGCAATTGGCGGTCGCGCGGCGGATTCGTGTCGC
GGTGTTCTTCACCGGTGACGAACTGACGATGCCCGGCGAGCCGCTGAAGCCCGGCGCAATCTACAACTCGAACCGCTTCA
CGCTGCGCGGGCTGCTGGAACGGCTCGGCTGCCACGTGACCGACTACGGGATCGTGCCCGATTCGCTCGCCGCGACGCGC
GATACGCTGCGCGCGGCTGCCCGCGATCACGACGTGATCCTGACGAGCGGCGGCGTGTCGGTCGGTGACGAGGATCACGT
GAAGCCGGCCGTCGAGGCCGAAGGGCGGCTCGCGCTGTGGCAGATCGCGATGAAGCCCGGCAAGCCGCTAGCTTACGGCG
CGGTGCGCCGCGGCGACGATCGCGCCGATGCGCACTTCATCGGGCTGCCCGGCAACCCGGTGTCGAGCTTCGTCACGTTC
CTGCTGTTCGTGCGGCCGTTCCTGCTGCGCCTGTCCGGCGTGCGCGACGTCGCGCCGCGCGCACTGTCGCTGCGTGCCGA
CTTTTCGCAAAACAAGGGCGACCGGCGCAACGAATTCCTGCGCGCGCGCGTCAACGCGGCCGGCGGCCTCGACCTGTTCC
CGAACCAGAGCTCGGCGGTGCTGACGTCGACGGTGTGGGGCGATGGCCTGATCGACAACCCGCCGCAGCACGCGATCAGC
GCCGGCGAGACCGTGCGTTTCATTCCGTTTTCCGAACTGCTGTCGTAA

Upstream 100 bases:

>100_bases
TTCGCGCGAATCACAGTTTCCGCATGTCGGCCATATCGCGCGCCCGCGCGACGGCGTCGCTACAATGACGTATTGAATCC
AACGATCCCCGATTCCATCG

Downstream 100 bases:

>100_bases
CGCGACGGCTTCCCGAACCATGAAGATTCAACTGAAATTTTTTGCAAGCGTACGCGAGGCACTGGGTGTCGCCGACGAGC
AGGCCGACGTGCCGGACAGC

Product: molybdopterin binding protein, MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMHTSAMDGYAVRVADLLHGDRR
LPVSQRIPAGHPAAPLAAGTAARIFTGATVPPGADAVVMQEQTAADGDAVEILHTPKAGEWITAQGADIRQGSVILPAGT
RLTPQALGLAASVGCAQLAVARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDDRADAHFIGLPGNPVSSFVTF
LLFVRPFLLRLSGVRDVAPRALSLRADFSQNKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAIS
AGETVRFIPFSELLS

Sequences:

>Translated_415_residues
MSNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMHTSAMDGYAVRVADLLHGDRR
LPVSQRIPAGHPAAPLAAGTAARIFTGATVPPGADAVVMQEQTAADGDAVEILHTPKAGEWITAQGADIRQGSVILPAGT
RLTPQALGLAASVGCAQLAVARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDDRADAHFIGLPGNPVSSFVTF
LLFVRPFLLRLSGVRDVAPRALSLRADFSQNKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAIS
AGETVRFIPFSELLS
>Mature_414_residues
SNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMHTSAMDGYAVRVADLLHGDRRL
PVSQRIPAGHPAAPLAAGTAARIFTGATVPPGADAVVMQEQTAADGDAVEILHTPKAGEWITAQGADIRQGSVILPAGTR
LTPQALGLAASVGCAQLAVARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATRD
TLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDDRADAHFIGLPGNPVSSFVTFL
LFVRPFLLRLSGVRDVAPRALSLRADFSQNKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAISA
GETVRFIPFSELLS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=401, Percent_Identity=35.1620947630923, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI66932975, Length=401, Percent_Identity=35.1620947630923, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=42.5974025974026, Blast_Score=275, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI25147659, Length=382, Percent_Identity=30.6282722513089, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=359, Percent_Identity=27.0194986072423, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136978, Length=405, Percent_Identity=34.320987654321, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24638841, Length=405, Percent_Identity=34.320987654321, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43492; Mature: 43361

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMH
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TSAMDGYAVRVADLLHGDRRLPVSQRIPAGHPAAPLAAGTAARIFTGATVPPGADAVVMQ
CCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHEEECCCCCCCCCEEEEE
EQTAADGDAVEILHTPKAGEWITAQGADIRQGSVILPAGTRLTPQALGLAASVGCAQLAV
CCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
ARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
HCEEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHHH
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDD
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEHHHCCCCC
RADAHFIGLPGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQNKGDRRNEFL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHH
RARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAISAGETVRFIPFSELLS
HHHHCCCCCCEECCCCCCCEEEEECCCCCCCCCCHHHHHCCCCEEEEECHHHHHC
>Mature Secondary Structure 
SNPNPAAPRAPMLSTAEALAALLDAAKPLPGAETVATLDALGRVLAADVSSPLDVPPMH
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TSAMDGYAVRVADLLHGDRRLPVSQRIPAGHPAAPLAAGTAARIFTGATVPPGADAVVMQ
CCCCCCHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHEEECCCCCCCCCEEEEE
EQTAADGDAVEILHTPKAGEWITAQGADIRQGSVILPAGTRLTPQALGLAASVGCAQLAV
CCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHH
ARRIRVAVFFTGDELTMPGEPLKPGAIYNSNRFTLRGLLERLGCHVTDYGIVPDSLAATR
HCEEEEEEEEECCEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHHH
DTLRAAARDHDVILTSGGVSVGDEDHVKPAVEAEGRLALWQIAMKPGKPLAYGAVRRGDD
HHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEHHHCCCCC
RADAHFIGLPGNPVSSFVTFLLFVRPFLLRLSGVRDVAPRALSLRADFSQNKGDRRNEFL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEECCCCCCCCCHHHHHH
RARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPQHAISAGETVRFIPFSELLS
HHHHCCCCCCEECCCCCCCEEEEECCCCCCCCCCHHHHHCCCCEEEEECHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]