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The map label for this gene is moeA [H]

Identifier: 78065692

GI number: 78065692

Start: 1154203

End: 1155501

Strand: Reverse

Name: moeA [H]

Synonym: Bcep18194_A4220

Alternate gene names: 78065692

Gene position: 1155501-1154203 (Counterclockwise)

Preceding gene: 78065693

Following gene: 78065691

Centisome position: 31.28

GC content: 72.06

Gene sequence:

>1299_bases
ATGATCACGCAATCCTCGCCCGCCCCCCGAACCGCACCCGATTCCGATGCCCCGCTGTCGCTCGCCGACGCGCAGGCGCT
CGCGTGCCGCTTCGCGGTGCCGGTCGACGCGTGTGACACGGTGACGCTGCGCGATGCACTCGACCGCGTGCTCGCGGCCA
ACGTGAACGCACCGTTCGACATTCCCGCATACGACAACTCGGCGATGGACGGCTATGCGTTCGACGGCAGCGCCGGCACG
CATGCATCGCAGCCAGCGGAGGTCGCGCTGACGGTCGCCGGCACCGCGCTCGCCGGCCATCCGTTCGACGGCGCCGTGGC
GTCCGGATCATGCGTGCGCATCATGACGGGCGCGCCGATGCCGGCCGGCTGCGATACGGTGATTCCGCAGGAACGCGTGC
GCGCCGACGGCGACACGATCCACTTCTCCTCGCACGACATCGCGCGCGGCGCGAACTGCCGCAAGGCCGGCGAGGATCTC
GCGCGCGGCGCGTGCGCGCTTGCCGCGGGCCGCATCCTGCGGCCGTCCGATCTCGGCCTGCTTGCGTCGTTCGGTGTCAC
CGAGGTTTCGGTGCGCCGGCGCGTGCGCGTCGCCGTGTTCTCCACCGGCGACGAACTGCGCGAGCCCGGCGAGCCGCTCG
GCCCCGGCGCACTGTACGACAGCAATCGCGGGATGCTGATCGCGATGCTCGAAAGGCTGCATGTCGACGCGGTCGATCTC
GGGATCGTCCGCGACGATCCCGCCGCGCTCGAAGCCGCATTGCGCGGTGCCGTCGCCGCGCAGGCCGATGCGGTGATCAC
GTCGGGCGGCGTATCGGTCGGCGAAGCCGACTTCACGCGCGACGTCATGGCCCGGCTCGGCGACGTGACGTTCGCGAGCC
TCGCGCTGCGTCCCGGCCGGCCGCTCGCGTGCGGCACGCTCGCACGCGCGGCCGATGGCGCCGGTCACACACTGTTTTTC
GGGCTGCCCGGCAACCCGGTCGCGTCTGCCGTGACGTTCTACGCGATCGTGCGCCCCGCGCTGCTGACGCTGGCCGGCGC
ACAGGCCCAGCCGCCGTCGATGCATACAGCACTCAGCACGCATGCGCTGAAGACGCGCCCGGGCCGCACCGACTACCTGC
GCGGCATCGCGACACGCGCCGCCGACGGCCGCTGGCACGTCGCGCCGGCCGGCTCGCAGAGTTCCGCATCGCTGAGCGGC
CTGTCGGCCGCCAACTGTTTCATCGTCCTGGGCCACGATACCGCGGCAGTCGACGCGGGCACCCCGGTCGACATCCTGCC
GCTCGACGGCCTGATCTGA

Upstream 100 bases:

>100_bases
CCCGTACGGTTCCCGCCCGCCGCACGCGAAACCCGCGCCCAGGCACCCTCCTCGCGCCACCGGCCACGAACCCGATACGC
CTTGCGGCGCAGTCCGACTG

Downstream 100 bases:

>100_bases
ATTCCACTATCGGTATATCTCTACGGGGGCAATCCACACATGAAGAAGCAAATTTCGTCGATCGCCGCGGGGCAGACCGC
AAAGGCGCTGATCCTGGTCT

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MITQSSPAPRTAPDSDAPLSLADAQALACRFAVPVDACDTVTLRDALDRVLAANVNAPFDIPAYDNSAMDGYAFDGSAGT
HASQPAEVALTVAGTALAGHPFDGAVASGSCVRIMTGAPMPAGCDTVIPQERVRADGDTIHFSSHDIARGANCRKAGEDL
ARGACALAAGRILRPSDLGLLASFGVTEVSVRRRVRVAVFSTGDELREPGEPLGPGALYDSNRGMLIAMLERLHVDAVDL
GIVRDDPAALEAALRGAVAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLACGTLARAADGAGHTLFF
GLPGNPVASAVTFYAIVRPALLTLAGAQAQPPSMHTALSTHALKTRPGRTDYLRGIATRAADGRWHVAPAGSQSSASLSG
LSAANCFIVLGHDTAAVDAGTPVDILPLDGLI

Sequences:

>Translated_432_residues
MITQSSPAPRTAPDSDAPLSLADAQALACRFAVPVDACDTVTLRDALDRVLAANVNAPFDIPAYDNSAMDGYAFDGSAGT
HASQPAEVALTVAGTALAGHPFDGAVASGSCVRIMTGAPMPAGCDTVIPQERVRADGDTIHFSSHDIARGANCRKAGEDL
ARGACALAAGRILRPSDLGLLASFGVTEVSVRRRVRVAVFSTGDELREPGEPLGPGALYDSNRGMLIAMLERLHVDAVDL
GIVRDDPAALEAALRGAVAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLACGTLARAADGAGHTLFF
GLPGNPVASAVTFYAIVRPALLTLAGAQAQPPSMHTALSTHALKTRPGRTDYLRGIATRAADGRWHVAPAGSQSSASLSG
LSAANCFIVLGHDTAAVDAGTPVDILPLDGLI
>Mature_432_residues
MITQSSPAPRTAPDSDAPLSLADAQALACRFAVPVDACDTVTLRDALDRVLAANVNAPFDIPAYDNSAMDGYAFDGSAGT
HASQPAEVALTVAGTALAGHPFDGAVASGSCVRIMTGAPMPAGCDTVIPQERVRADGDTIHFSSHDIARGANCRKAGEDL
ARGACALAAGRILRPSDLGLLASFGVTEVSVRRRVRVAVFSTGDELREPGEPLGPGALYDSNRGMLIAMLERLHVDAVDL
GIVRDDPAALEAALRGAVAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLACGTLARAADGAGHTLFF
GLPGNPVASAVTFYAIVRPALLTLAGAQAQPPSMHTALSTHALKTRPGRTDYLRGIATRAADGRWHVAPAGSQSSASLSG
LSAANCFIVLGHDTAAVDAGTPVDILPLDGLI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=428, Percent_Identity=33.6448598130841, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI66932975, Length=428, Percent_Identity=33.6448598130841, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787049, Length=381, Percent_Identity=45.4068241469816, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI25147659, Length=400, Percent_Identity=28.25, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=229, Percent_Identity=28.82096069869, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136978, Length=392, Percent_Identity=30.3571428571429, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=392, Percent_Identity=30.3571428571429, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44096; Mature: 44096

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITQSSPAPRTAPDSDAPLSLADAQALACRFAVPVDACDTVTLRDALDRVLAANVNAPFD
CCCCCCCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCC
IPAYDNSAMDGYAFDGSAGTHASQPAEVALTVAGTALAGHPFDGAVASGSCVRIMTGAPM
CCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCEECCCCCCCCCCCCCEEEEEECCCC
PAGCDTVIPQERVRADGDTIHFSSHDIARGANCRKAGEDLARGACALAAGRILRPSDLGL
CCCCCCCCCHHHHCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
LASFGVTEVSVRRRVRVAVFSTGDELREPGEPLGPGALYDSNRGMLIAMLERLHVDAVDL
HHHCCCHHHHHHCEEEEEEEECCHHHHCCCCCCCCCCEEECCCCCHHHHHHHHCCCCEEE
GIVRDDPAALEAALRGAVAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGR
EEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PLACGTLARAADGAGHTLFFGLPGNPVASAVTFYAIVRPALLTLAGAQAQPPSMHTALST
CCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
HALKTRPGRTDYLRGIATRAADGRWHVAPAGSQSSASLSGLSAANCFIVLGHDTAAVDAG
HHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCC
TPVDILPLDGLI
CCEEEECCCCCC
>Mature Secondary Structure
MITQSSPAPRTAPDSDAPLSLADAQALACRFAVPVDACDTVTLRDALDRVLAANVNAPFD
CCCCCCCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCC
IPAYDNSAMDGYAFDGSAGTHASQPAEVALTVAGTALAGHPFDGAVASGSCVRIMTGAPM
CCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCEECCCCCCCCCCCCCEEEEEECCCC
PAGCDTVIPQERVRADGDTIHFSSHDIARGANCRKAGEDLARGACALAAGRILRPSDLGL
CCCCCCCCCHHHHCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
LASFGVTEVSVRRRVRVAVFSTGDELREPGEPLGPGALYDSNRGMLIAMLERLHVDAVDL
HHHCCCHHHHHHCEEEEEEEECCHHHHCCCCCCCCCCEEECCCCCHHHHHHHHCCCCEEE
GIVRDDPAALEAALRGAVAAQADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGR
EEECCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
PLACGTLARAADGAGHTLFFGLPGNPVASAVTFYAIVRPALLTLAGAQAQPPSMHTALST
CCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
HALKTRPGRTDYLRGIATRAADGRWHVAPAGSQSSASLSGLSAANCFIVLGHDTAAVDAG
HHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCC
TPVDILPLDGLI
CCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]