Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 78065579

GI number: 78065579

Start: 1035836

End: 1036519

Strand: Direct

Name: gmk

Synonym: Bcep18194_A4107

Alternate gene names: 78065579

Gene position: 1035836-1036519 (Clockwise)

Preceding gene: 161702965

Following gene: 78065580

Centisome position: 28.04

GC content: 64.91

Gene sequence:

>684_bases
ATGACCCAATCCACCCACGACGGCCACGCCGCGCATTCGCTGCACGGCGGCGTCTATCCCGGCAACCTGTTCATGGTCGT
CGCGCCGTCGGGCGCCGGCAAGTCGACGCTCGTGAATGCGCTGCTGTCGAAGGACAGCGACATCTGCCTGTCGATCTCGT
ACACGACGCGCAAACCGCGCCCGGGCGAGCAGGACGGCCAGCACTATCACTTCACGACGGTCGAGGATTTCCGCACGCGT
CACGCGGCGCATGAATTCCTCGAGAGCGCGGAAGTGCACGGCAACTACTACGGCACGTCGCGCGTCTGGATCGAAGAGCA
GATGAAGAACGGCCACGACGTGCTGCTCGAAATCGACTGGCAGGGTGCGCTGCAGGTGAAGAAGCAGTTCCGCAACGCGG
TCGGCATCTTCATCCTGCCGCCGTCGCTCGACGCGCTCGAGGAGCGCCTGAAGAAGCGCGGCCAGGACGAACCGAAAGTG
ATCACGCGCCGCCTGCTGGCCGCCGGCAGCGAGATCGCGCACGCGCCCGAAGCGGAATACGTGGTGATCAACGAGAATTT
CGAGCGTGCGCTCGCGGAGCTCGAATGCATCGTCGCGGCCACGCGCCTGCGCTTTGCTTCGCAGTACGCGCGACACACGG
AGCTGTTCATCGAGCTCGGCATCCATCTGCCCCACGCGGAATGA

Upstream 100 bases:

>100_bases
CTCGAAGGCGGCGGCGAAGGAACTCGCCGACGCATCGATGGCGCTCAAGCTGTTGATCGAGCAGATGCGCGAGCAAGTGC
AAAACCTGGAGTAAAGCAAC

Downstream 100 bases:

>100_bases
CGCGGGGGACGAGGGACATAAGGTAGAATAAGGACTATATTCAGAAGGAATTACCAACATGGCTCGCATTACCGTCGAAG
ACTGCCTGAAGCAAATCCCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTQSTHDGHAAHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRTR
HAAHEFLESAEVHGNYYGTSRVWIEEQMKNGHDVLLEIDWQGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPKV
ITRRLLAAGSEIAHAPEAEYVVINENFERALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE

Sequences:

>Translated_227_residues
MTQSTHDGHAAHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRTR
HAAHEFLESAEVHGNYYGTSRVWIEEQMKNGHDVLLEIDWQGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPKV
ITRRLLAAGSEIAHAPEAEYVVINENFERALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE
>Mature_226_residues
TQSTHDGHAAHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRTRH
AAHEFLESAEVHGNYYGTSRVWIEEQMKNGHDVLLEIDWQGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPKVI
TRRLLAAGSEIAHAPEAEYVVINENFERALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=38.8571428571429, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=38.8571428571429, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=38.8571428571429, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI262118259, Length=134, Percent_Identity=31.3432835820896, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4505237, Length=134, Percent_Identity=31.3432835820896, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI262118255, Length=134, Percent_Identity=31.3432835820896, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI262118263, Length=134, Percent_Identity=31.3432835820896, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=26.4367816091954, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=26.5, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=47.7611940298507, Blast_Score=195, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=37.2222222222222, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=37.2222222222222, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=37.3626373626374, Blast_Score=128, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.3626373626374, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25419; Mature: 25288

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSTHDGHAAHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPR
CCCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
PGEQDGQHYHFTTVEDFRTRHAAHEFLESAEVHGNYYGTSRVWIEEQMKNGHDVLLEIDW
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEECC
QGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPKVITRRLLAAGSEIAHAPEAEY
CHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFERALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure 
TQSTHDGHAAHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDICLSISYTTRKPR
CCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
PGEQDGQHYHFTTVEDFRTRHAAHEFLESAEVHGNYYGTSRVWIEEQMKNGHDVLLEIDW
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEECC
QGALQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPKVITRRLLAAGSEIAHAPEAEY
CHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFERALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA