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The map label for this gene is 78065388

Identifier: 78065388

GI number: 78065388

Start: 827234

End: 828538

Strand: Direct

Name: 78065388

Synonym: Bcep18194_A3914

Alternate gene names: NA

Gene position: 827234-828538 (Clockwise)

Preceding gene: 78065387

Following gene: 78065394

Centisome position: 22.39

GC content: 65.67

Gene sequence:

>1305_bases
ATGAGCGATACCCAAGACTGGCGCGCGACGCTCGACCCGGCTCGCAAGAGCTGGGTCGAGACGGCGAACGATTCCGCCTG
CGATTTCCCGATCCAGAACCTGCCGTTCGGGATCTTCAGCGATGCGAAACAAGCGTCGCGCCGTGCCGGCGTGGCGCTCG
GCGACCAGATCGTCGATCTTGCAGCGCTCGCTCGTGCTGGCCTCGTGACGCTGCCGGCCGGCGCCGATGTGTTTGCCGCA
CCGACGCTCAACGCGTTCATCGCGCTCGGCCGCGACGCATGGCGCAGCGTGCGCGTGCAGCTGTCGGACCTGTTCTCGCG
CGACAACGCGAAGCTGCGTGACGATGCTTCGTTGCGAGCACAGGTGCTCGTCGCGCAGCGCGACGCGACGCTGCATCTGC
CGGTCGAGATTCCCGGCTACACCGATTTCTATTCGTCGAAGGAGCACGCGACCAACGTCGGCTCGATGTTCCGTGATCCG
AAGAATGCACTGCTGCCGAACTGGTCGGAGATGCCGATCGGCTACAACGGCCGTGCGTCGTCGGTGATCGTGAGCGGTAC
GCCGGTGCGGCGTCCGAACGGGCAACTGAAGCTGCCCGACCAGGAGCGTCCGGTGTTCGGTGCATGCCGCAAGCTCGACA
TCGAACTGGAGACAGGTTTCATCGTCGGCCAGGGCAACGCGCTCGGCGAGCCGATCGCGTGCGAGGACGCGGAAGCGCAT
ATCTTCGGGATGGTGCTGCTGAACGACTGGAGCGCGCGCGACATCCAGCAATGGGAATACGTGCCGCTCGGCCCGTTCAA
TGCGAAGACGTTCGCGACGACGATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAACCGTTCCGCGTCGCGCAGCCGG
AGCAGTCGCCGCAGCCGCTCGCGTATCTGCAGCACGCAGGCAAGCATGCGTTCGACATTGCACTCGAAGTGACGCTGCGC
GAGGAAGGGGCGGCCGAAGCGACGTCGATCAGCCGCACGAACTTCAAGCACATGTACTGGACGATGGCGCAGCAGCTCGC
GCATCACACGGTCGCGGGCTGCAACACGCGTGTGGGCGACCTGATGGGTTCGGGGACGATCAGCGGGCCGACGAAGGATT
CGTTCGGCAGCCTGCTCGAACTGACGTGGAACGGCAAGGAGCCGGTTGCGCTGAACGGCGGCGGCAGCCGCGCGTTCATC
GAGGACGGCGACGAGCTCACGCTCGCCGGATGGTGCCAGGGTGATGGCTATCGCGTCGGCTTCGGTGCGTGTGTCGGCAA
GATCCTGCCGGCGTTGAAGGCGTAA

Upstream 100 bases:

>100_bases
TGATCCGGCCGACGCGCTATGCGCTCGACACCGCGCAGCTGCAGGCGGACTACTTCGAATGCTGGCAAGGCATCAAGAAA
CACTTCAATCCGGAGCAACG

Downstream 100 bases:

>100_bases
CGCGCAACGTAGCGCGTCCGTGAGCACGACGGCCCGCATTGCGCGGGCCGTCGTCGTTTATGCAGTGTGATCGGCGTATC
CGTCGCCGGGCGGCGCGCTT

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSDTQDWRATLDPARKSWVETANDSACDFPIQNLPFGIFSDAKQASRRAGVALGDQIVDLAALARAGLVTLPAGADVFAA
PTLNAFIALGRDAWRSVRVQLSDLFSRDNAKLRDDASLRAQVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVIVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGQGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLQHAGKHAFDIALEVTLR
EEGAAEATSISRTNFKHMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRAFI
EDGDELTLAGWCQGDGYRVGFGACVGKILPALKA

Sequences:

>Translated_434_residues
MSDTQDWRATLDPARKSWVETANDSACDFPIQNLPFGIFSDAKQASRRAGVALGDQIVDLAALARAGLVTLPAGADVFAA
PTLNAFIALGRDAWRSVRVQLSDLFSRDNAKLRDDASLRAQVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDP
KNALLPNWSEMPIGYNGRASSVIVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGQGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLQHAGKHAFDIALEVTLR
EEGAAEATSISRTNFKHMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRAFI
EDGDELTLAGWCQGDGYRVGFGACVGKILPALKA
>Mature_433_residues
SDTQDWRATLDPARKSWVETANDSACDFPIQNLPFGIFSDAKQASRRAGVALGDQIVDLAALARAGLVTLPAGADVFAAP
TLNAFIALGRDAWRSVRVQLSDLFSRDNAKLRDDASLRAQVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDPK
NALLPNWSEMPIGYNGRASSVIVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGQGNALGEPIACEDAEAHI
FGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLQHAGKHAFDIALEVTLRE
EGAAEATSISRTNFKHMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRAFIE
DGDELTLAGWCQGDGYRVGFGACVGKILPALKA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=419, Percent_Identity=57.9952267303103, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17568863, Length=418, Percent_Identity=55.9808612440191, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24657182, Length=418, Percent_Identity=51.4354066985646, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46995; Mature: 46864

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTQDWRATLDPARKSWVETANDSACDFPIQNLPFGIFSDAKQASRRAGVALGDQIVDL
CCCCCCHHHHCCHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
AALARAGLVTLPAGADVFAAPTLNAFIALGRDAWRSVRVQLSDLFSRDNAKLRDDASLRA
HHHHHCCEEEECCCCCEEECCHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
QVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
SVIVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGQGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHCCEEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPEQSPQPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCHHEEECCCEEEEEECCCCCCCCCCCCCCCHH
AYLQHAGKHAFDIALEVTLREEGAAEATSISRTNFKHMYWTMAQQLAHHTVAGCNTRVGD
HHHHHCCCCEEEEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRAFIEDGDELTLAGWCQGDGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCEEEEECCCEEEEEEEECCCCEEEE
FGACVGKILPALKA
HHHHHHHHHHHHCC
>Mature Secondary Structure 
SDTQDWRATLDPARKSWVETANDSACDFPIQNLPFGIFSDAKQASRRAGVALGDQIVDL
CCCCCHHHHCCHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
AALARAGLVTLPAGADVFAAPTLNAFIALGRDAWRSVRVQLSDLFSRDNAKLRDDASLRA
HHHHHCCEEEECCCCCEEECCHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
QVLVAQRDATLHLPVEIPGYTDFYSSKEHATNVGSMFRDPKNALLPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCC
SVIVSGTPVRRPNGQLKLPDQERPVFGACRKLDIELETGFIVGQGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHCCEEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNAKTFATTISPWIVTLDALEPFRVAQPEQSPQPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCHHEEECCCEEEEEECCCCCCCCCCCCCCCHH
AYLQHAGKHAFDIALEVTLREEGAAEATSISRTNFKHMYWTMAQQLAHHTVAGCNTRVGD
HHHHHCCCCEEEEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPVALNGGGSRAFIEDGDELTLAGWCQGDGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCEEEEECCCEEEEEEEECCCCEEEE
FGACVGKILPALKA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA