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The map label for this gene is hmgA [H]

Identifier: 78065387

GI number: 78065387

Start: 825903

End: 827237

Strand: Direct

Name: hmgA [H]

Synonym: Bcep18194_A3913

Alternate gene names: 78065387

Gene position: 825903-827237 (Clockwise)

Preceding gene: 78065386

Following gene: 78065388

Centisome position: 22.36

GC content: 67.72

Gene sequence:

>1335_bases
ATGACGCTTGACCTGTCGAAACCGGCGAACGCCGGCTACCAGAGCGGTTTCGCGAACGAATTCGCGACCGAGGCACTGCC
CGGCGCGTTGCCGCACGGCCGCAACTCACCGCAGCGCGCGCCGTACGGGCTGTATGCGGAGCAGCTGTCGGGCACCGCGT
TTACCGCGCCGCGCGGCCACAACCGCCGCTCGTGGCTGTACCGCATCCGCCCGGCGGCCGTGCACCGGCCGTTCGAGCCG
TATGCGGGCCCGCAGCGCCTCGTGTCGGAATTCGGCGACTCGGCCGACGTGCCGCCGACGCCGCCGGACCAGCTGCGCTG
GGATCCGCTGCCGATGCCGGTCGAGCCGACCGATTTCGTCGACGGGCTCGTGACGATGGCCGGCAATGGCTCGGCCGCAG
CGATGAACGGCTGCGCGATCCACCTGTACGCGGCGAACCGCTCGATGCAGGACCGCTTCTTCTACAGCGCGGACGGCGAA
CTGCTGATCGTGCCGCAGCAGGGGCGCCTGTTCATCGCGACCGAATTCGGCCGGGTCGAGGTCGAGCCGTTCGAGATCGC
GGTGATCCCGCGTGGCGTGCGTTTTTCCGTCACGCTGCCGGACGGCGACGCGCGCGGCTACATCTGCGAAAACTTCGGCG
CGCAATTGCGCCTGCCGGATCTCGGCCCGATCGGCTCGAACGGTCTCGCGAACCCGCGCGACTTCCTGACGCCGCAAGCC
GCGTACGAAGACCGCGAAGGCGCATTCGAGCTGATCGCGAAGCTGAACGGCCGCCTGTGGCGCGCGGACATCGGTCATTC
GCCGCTCGACGTCGTCGCATGGCACGGCAACTACGCGCCTTACAAGTACGACCTGCGCCTGTTCAACACGATCGGCTCGA
TCAGCTTCGACCATCCCGATCCGTCGATCTTCCTGGTGCTGCAGTCGCAGAGCGACACGCCGGGCGTCGACACGATCGAC
TTCGTGATCTTCCCGCCGCGCTGGCTCGCGGCCGAGGACACGTTCCGCCCGCCCTGGTTCCACCGCAACGTCGCGAGCGA
ATTCATGGGGCTCGTGCACGGCGCGTACGACGCGAAGGCCGAAGGCTTCGTGCCGGGCGGCGCGAGCCTGCACAACTGCA
TGTCGGGCCACGGGCCCGACGCGGATACGTTCGAGAAGGCGTCCGCGAGCGACACGACGAAGCCGCACAAGGTCGACGCG
ACGATGGCGTTCATGTTCGAAACCCGCACGCTGATCCGGCCGACGCGCTATGCGCTCGACACCGCGCAGCTGCAGGCGGA
CTACTTCGAATGCTGGCAAGGCATCAAGAAACACTTCAATCCGGAGCAACGATGA

Upstream 100 bases:

>100_bases
GCTGTGCTCGGCGCTGTTCGTCCTCGGGCTTGCCGGTGTGACGCGGCGCAATGGCGCGCAGGCGCCGAACGCCGCGATGA
ATTGAGGGAGAAAGGAAACG

Downstream 100 bases:

>100_bases
GCGATACCCAAGACTGGCGCGCGACGCTCGACCCGGCTCGCAAGAGCTGGGTCGAGACGGCGAACGATTCCGCCTGCGAT
TTCCCGATCCAGAACCTGCC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTLDLSKPANAGYQSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEP
YAGPQRLVSEFGDSADVPPTPPDQLRWDPLPMPVEPTDFVDGLVTMAGNGSAAAMNGCAIHLYAANRSMQDRFFYSADGE
LLIVPQQGRLFIATEFGRVEVEPFEIAVIPRGVRFSVTLPDGDARGYICENFGAQLRLPDLGPIGSNGLANPRDFLTPQA
AYEDREGAFELIAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLQSQSDTPGVDTID
FVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDA
TMAFMFETRTLIRPTRYALDTAQLQADYFECWQGIKKHFNPEQR

Sequences:

>Translated_444_residues
MTLDLSKPANAGYQSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEP
YAGPQRLVSEFGDSADVPPTPPDQLRWDPLPMPVEPTDFVDGLVTMAGNGSAAAMNGCAIHLYAANRSMQDRFFYSADGE
LLIVPQQGRLFIATEFGRVEVEPFEIAVIPRGVRFSVTLPDGDARGYICENFGAQLRLPDLGPIGSNGLANPRDFLTPQA
AYEDREGAFELIAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLQSQSDTPGVDTID
FVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDA
TMAFMFETRTLIRPTRYALDTAQLQADYFECWQGIKKHFNPEQR
>Mature_443_residues
TLDLSKPANAGYQSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGHNRRSWLYRIRPAAVHRPFEPY
AGPQRLVSEFGDSADVPPTPPDQLRWDPLPMPVEPTDFVDGLVTMAGNGSAAAMNGCAIHLYAANRSMQDRFFYSADGEL
LIVPQQGRLFIATEFGRVEVEPFEIAVIPRGVRFSVTLPDGDARGYICENFGAQLRLPDLGPIGSNGLANPRDFLTPQAA
YEDREGAFELIAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPDPSIFLVLQSQSDTPGVDTIDF
VIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDAT
MAFMFETRTLIRPTRYALDTAQLQADYFECWQGIKKHFNPEQR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=444, Percent_Identity=52.7027027027027, Blast_Score=463, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17507969, Length=432, Percent_Identity=53.9351851851852, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24583650, Length=434, Percent_Identity=51.8433179723502, Blast_Score=440, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 49094; Mature: 48962

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDLSKPANAGYQSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGH
CEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHRPFEPYAGPQRLVSEFGDSADVPPTPPDQLRWDPLPMPVEPTDFV
CCCCEEEEECHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
DGLVTMAGNGSAAAMNGCAIHLYAANRSMQDRFFYSADGELLIVPQQGRLFIATEFGRVE
HHHEEECCCCCCEEECCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCEEEEEECCEEE
VEPFEIAVIPRGVRFSVTLPDGDARGYICENFGAQLRLPDLGPIGSNGLANPRDFLTPQA
ECCEEEEEECCCEEEEEECCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCHHHCCCCH
AYEDREGAFELIAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPD
HCCCCCHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCCEEEEEEEEECCCCCEECCCC
PSIFLVLQSQSDTPGVDTIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKA
CEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
EGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDATMAFMFETRTLIRPTRYALD
CCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHCCHHHHHH
TAQLQADYFECWQGIKKHFNPEQR
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLDLSKPANAGYQSGFANEFATEALPGALPHGRNSPQRAPYGLYAEQLSGTAFTAPRGH
EECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCC
NRRSWLYRIRPAAVHRPFEPYAGPQRLVSEFGDSADVPPTPPDQLRWDPLPMPVEPTDFV
CCCCEEEEECHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
DGLVTMAGNGSAAAMNGCAIHLYAANRSMQDRFFYSADGELLIVPQQGRLFIATEFGRVE
HHHEEECCCCCCEEECCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCEEEEEECCEEE
VEPFEIAVIPRGVRFSVTLPDGDARGYICENFGAQLRLPDLGPIGSNGLANPRDFLTPQA
ECCEEEEEECCCEEEEEECCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCHHHCCCCH
AYEDREGAFELIAKLNGRLWRADIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISFDHPD
HCCCCCHHHHHHHHHCCEEEEECCCCCCCEEEEECCCCCCEEEEEEEEECCCCCEECCCC
PSIFLVLQSQSDTPGVDTIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGAYDAKA
CEEEEEEECCCCCCCCCEEEEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
EGFVPGGASLHNCMSGHGPDADTFEKASASDTTKPHKVDATMAFMFETRTLIRPTRYALD
CCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHCCHHHHHH
TAQLQADYFECWQGIKKHFNPEQR
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA