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The map label for this gene is pcaK [H]

Identifier: 78065386

GI number: 78065386

Start: 824526

End: 825887

Strand: Direct

Name: pcaK [H]

Synonym: Bcep18194_A3912

Alternate gene names: 78065386

Gene position: 824526-825887 (Clockwise)

Preceding gene: 78065385

Following gene: 78065387

Centisome position: 22.32

GC content: 69.97

Gene sequence:

>1362_bases
ATGAGCGCGGCGCCGGCCGACGCGCGCGTGCTCGAAGTCGAGAGCGTGATCGACGACACCCATCGCCCGGGTTTTCACTG
GATGCTGCTCGTGTTGTGCGGGCTGTGCCTCGTGATCGACGGTTTCGATGCGCAGGCGATGGGCTACGTCGCGCCGAGCG
TGATCGCCGAATGGGGCGTGCCGAAGCAGGCGCTCGGGCCCGTGTTCAGCGCGAGCCTGTTCGGGATGCTGCTCGGCGCG
CTCGGGCTGTCGGTGCTGGCCGACCGGATCGGGCGGCGCCCGGTGCTGATCGGCTCGACGCTGTTCTTCGCGGTGACGAT
GCTCGCGACGCCGTTCGCGGGTTCGATCCCGGTGCTGATGGCGCTGCGCTTCGTCACGGGCCTCGGCCTCGGCTGCATCA
TGCCGAACGCGATGGCGCTGGTCGGCGAGTTCAGCCCGGCCACGCATCGCGTGAAGCGGATGATGATCGTGTCGTGCGGC
TTCACGCTCGGCGCGGCGCTCGGCGGCTTCATCAGCGCCGCGCTGATTCCGGCGCTCGGCTGGCGGTCGGTGTTCTTCGT
CGGCGGCGCGGTGCCGCTCGTGCTGACGATCGCGATGGTTGCGCGGCTGCCCGAATCGCTGCAGTTCCTGGTGCTGAAAG
GGCGCGTCGCGCAGGCACGCGACTGGCTCGCGCACTTCGCGCCGCAGGCCGGCATCGATGCGAATACGCGGCTCGTGGTA
CGCGAGCGCGCCGCGACCGGCGCGCCGGTCGCCGAGCTGTTCAGCCACGGCCGCCTGCCGGTCACGCTGCTGTTGTGGGC
GATCAGCTTCATGAACCTGATCGATCTGTATTTCCTGTCGAACTGGCTGCCGACCGTGATGCGCGACGCCGGCTATTCGC
AGGGCACGGCGGTGATCGTCGGCACGGTGCTGCAGACGGGCGGCGTGATCGGCACGCTGTCGCTCGGCTGGTTCATCGAA
CGCTACGGCTTCGTGCGCGTGCTGTTCGCATGCTTCGCGTGCGCGGCCGTGTCGGTGGGGCTGATCGGCTCGGTCGCGCA
TGCGCTGCCGTGGCTGCTGGTGGTGGTGTTCGCGGGCGGGTTCTGCGTGGTCGGCGGGCAGCCGGCCGTGAACGCGCTCG
CGGGCCAGTATTACCCGACGTCGCTGCGCTCGACGGGCATCGGCTGGAGCCTCGGCATCGGCCGGATCGGCTCGGTGCTC
GGGCCGCTCGTCGGCGGACAACTGATTGCGCTCAACTGGTCGAACGGTGCGCTGTTCCACGCGGCCGCGGTGCCCGTGCT
GTGCTCGGCGCTGTTCGTCCTCGGGCTTGCCGGTGTGACGCGGCGCAATGGCGCGCAGGCGCCGAACGCCGCGATGAATT
GA

Upstream 100 bases:

>100_bases
TCGCGAACCAGATCGGCGACGCCGGCGTGCTGCGCGAAGCGATGGCGCTCGCGCGCCAGGGCGTGACACCGCCCGTGCAT
CCGGCCGCCGAGGTGACGCA

Downstream 100 bases:

>100_bases
GGGAGAAAGGAAACGATGACGCTTGACCTGTCGAAACCGGCGAACGCCGGCTACCAGAGCGGTTTCGCGAACGAATTCGC
GACCGAGGCACTGCCCGGCG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSAAPADARVLEVESVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGA
LGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPATHRVKRMMIVSCG
FTLGAALGGFISAALIPALGWRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLAHFAPQAGIDANTRLVV
RERAATGAPVAELFSHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSQGTAVIVGTVLQTGGVIGTLSLGWFIE
RYGFVRVLFACFACAAVSVGLIGSVAHALPWLLVVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVL
GPLVGGQLIALNWSNGALFHAAAVPVLCSALFVLGLAGVTRRNGAQAPNAAMN

Sequences:

>Translated_453_residues
MSAAPADARVLEVESVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGA
LGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPATHRVKRMMIVSCG
FTLGAALGGFISAALIPALGWRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLAHFAPQAGIDANTRLVV
RERAATGAPVAELFSHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSQGTAVIVGTVLQTGGVIGTLSLGWFIE
RYGFVRVLFACFACAAVSVGLIGSVAHALPWLLVVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVL
GPLVGGQLIALNWSNGALFHAAAVPVLCSALFVLGLAGVTRRNGAQAPNAAMN
>Mature_452_residues
SAAPADARVLEVESVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGAL
GLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPATHRVKRMMIVSCGF
TLGAALGGFISAALIPALGWRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLAHFAPQAGIDANTRLVVR
ERAATGAPVAELFSHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSQGTAVIVGTVLQTGGVIGTLSLGWFIER
YGFVRVLFACFACAAVSVGLIGSVAHALPWLLVVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLG
PLVGGQLIALNWSNGALFHAAAVPVLCSALFVLGLAGVTRRNGAQAPNAAMN

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=427, Percent_Identity=26.2295081967213, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI8923870, Length=370, Percent_Identity=27.5675675675676, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI166064021, Length=351, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI213021148, Length=461, Percent_Identity=23.4273318872017, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI7662270, Length=220, Percent_Identity=24.0909090909091, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87081723, Length=418, Percent_Identity=33.2535885167464, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1786229, Length=387, Percent_Identity=21.9638242894057, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082231, Length=429, Percent_Identity=22.1445221445221, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788068, Length=455, Percent_Identity=23.956043956044, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082404, Length=385, Percent_Identity=21.2987012987013, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=24.2268041237113, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788074, Length=247, Percent_Identity=25.5060728744939, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=422, Percent_Identity=23.2227488151659, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17565978, Length=277, Percent_Identity=25.9927797833935, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71980582, Length=343, Percent_Identity=23.0320699708455, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI19922874, Length=435, Percent_Identity=22.9885057471264, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI161077756, Length=461, Percent_Identity=23.2104121475054, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24640198, Length=227, Percent_Identity=25.9911894273128, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640196, Length=227, Percent_Identity=25.9911894273128, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640200, Length=227, Percent_Identity=25.9911894273128, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922616, Length=368, Percent_Identity=24.1847826086957, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47317; Mature: 47185

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAAPADARVLEVESVIDDTHRPGFHWMLLVLCGLCLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PKQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHH
ALRFVTGLGLGCIMPNAMALVGEFSPATHRVKRMMIVSCGFTLGAALGGFISAALIPALG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRSVFFVGGAVPLVLTIAMVARLPESLQFLVLKGRVAQARDWLAHFAPQAGIDANTRLVV
HHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEE
RERAATGAPVAELFSHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSQGTAVIV
EECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEE
GTVLQTGGVIGTLSLGWFIERYGFVRVLFACFACAAVSVGLIGSVAHALPWLLVVVFAGG
HHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWSNGALFH
EEEECCCHHHHHHHCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCCCCHH
AAAVPVLCSALFVLGLAGVTRRNGAQAPNAAMN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]