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The map label for this gene is purM [H]

Identifier: 78065322

GI number: 78065322

Start: 755441

End: 756496

Strand: Direct

Name: purM [H]

Synonym: Bcep18194_A3848

Alternate gene names: 78065322

Gene position: 755441-756496 (Clockwise)

Preceding gene: 78065315

Following gene: 78065323

Centisome position: 20.45

GC content: 65.91

Gene sequence:

>1056_bases
ATGAATCCTCCGAAATCCGCTCCTGACGCTCAGGGTCTGTCCTATCGCGACGCAGGTGTCGACATCGACGCGGGCGACGC
GCTCATCGACAAGATCAAGCCTTTTGCGAAGAAAACCCTGCGCGACGGCGTGCTCGGCGGCATCGGCGGGTTCGGCGCGC
TGTTCGAAGTGCCGAAGAAGTACAAGGAGCCCGTGCTCGTGTCGGGTACCGACGGCGTGGGCACCAAGCTCAAGCTGGCG
TTTCATCTGAACAAACACGACACCGTCGGCCAGGATCTCGTCGCGATGAGCGTGAACGACATCCTCGTGCAGGGCGCCGA
GCCGCTGTTCTTCCTCGACTACTTCGCGTGCGGCAAGCTCGACGTCGACACCGCGGCAACGGTCGTCAAGGGCATCGCGC
AGGGTTGCGAACTGTCGGGCTGCGCGCTGATCGGCGGTGAAACGGCCGAAATGCCGGGCATGTACCCGGACGGCGAATAC
GACCTGGCAGGCTTCGCGGTCGGCGCGGTCGAGAAGAGCAAGATCATCGACGGCAGCACGATCGCCGAAGGCGACGTGGT
GCTGGGCCTCGCATCGAGCGGCATCCACTCGAACGGCTTCTCGCTCGTGCGCAAGATCATCGAGCGCGCGAACCCCGACC
TGTCGGCCGATTTCCACGGCCGCTCGCTGGCCGACGCGCTGATGGCGCCGACCCGCATCTACGTGAAGCCGCTGCTCGCG
CTGATGCAGAAGCTGACGGTGAAGGGCATGGCGCACATCACGGGCGGCGGTCTCGTCGAGAACATTCCGCGCGTGCTGCG
CGAAGGCCTCACCGCCGAGCTCGACCAGGACGCATGGCCGCTGCCGCCGCTGTTCAAGTGGCTGCAGGAGCACGGCGGTG
TTGCCGATGCGGAAATGCACCGCGTGTTCAACTGCGGCATCGGCATGGCCGTGATCGTGTCGGCGGCCGATGCCGACGCA
GCGATCGCCGACCTGACCGCCGCCGGCGAACAGGTGTGGAAGATCGGTACCGTGCGTGCGACCCGCGAAGGCGAGGCGCA
GACGGTCGTGGTCTGA

Upstream 100 bases:

>100_bases
TTGACCAAGATGCAATCCCTGACGATTCGGTGCTGGGAATTCCGGCCAACGGGCCGGCTTCGGGTAAAATCGCATTTTAC
CGACCTTCTCGCATTCCCCC

Downstream 100 bases:

>100_bases
CGCGCTGCCAGCAGCAGATGCAGCAAGGAAAGCCGCCCGGAGTCGATCCGGGCGGCTTTTTTTTCGGGCGTTGCGTGGCA
TGCGGGCGCGCGCCGATGAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMQKLTVKGMAHITGGGLVENIPRVLREGLTAELDQDAWPLPPLFKWLQEHGGVADAEMHRVFNCGIGMAVIVSAADADA
AIADLTAAGEQVWKIGTVRATREGEAQTVVV

Sequences:

>Translated_351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMQKLTVKGMAHITGGGLVENIPRVLREGLTAELDQDAWPLPPLFKWLQEHGGVADAEMHRVFNCGIGMAVIVSAADADA
AIADLTAAGEQVWKIGTVRATREGEAQTVVV
>Mature_351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMQKLTVKGMAHITGGGLVENIPRVLREGLTAELDQDAWPLPPLFKWLQEHGGVADAEMHRVFNCGIGMAVIVSAADADA
AIADLTAAGEQVWKIGTVRATREGEAQTVVV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=54.1547277936963, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=54.1547277936963, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=54.1547277936963, Blast_Score=373, Evalue=1e-103,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=59.4752186588921, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567511, Length=344, Percent_Identity=44.4767441860465, Blast_Score=265, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=48.955223880597, Blast_Score=320, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24582400, Length=303, Percent_Identity=43.2343234323432, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36809; Mature: 36809

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YKEPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGST
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCCCCCC
IAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LMQKLTVKGMAHITGGGLVENIPRVLREGLTAELDQDAWPLPPLFKWLQEHGGVADAEMH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
RVFNCGIGMAVIVSAADADAAIADLTAAGEQVWKIGTVRATREGEAQTVVV
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHEECCEEECCCCCCCEEEC
>Mature Secondary Structure
MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YKEPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVDTAATVVKGIAQGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGST
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCCCCCC
IAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LMQKLTVKGMAHITGGGLVENIPRVLREGLTAELDQDAWPLPPLFKWLQEHGGVADAEMH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
RVFNCGIGMAVIVSAADADAAIADLTAAGEQVWKIGTVRATREGEAQTVVV
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHEECCEEECCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA