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The map label for this gene is pyrC [H]

Identifier: 78065238

GI number: 78065238

Start: 658457

End: 659521

Strand: Direct

Name: pyrC [H]

Synonym: Bcep18194_A3762

Alternate gene names: 78065238

Gene position: 658457-659521 (Clockwise)

Preceding gene: 78065234

Following gene: 78065241

Centisome position: 17.82

GC content: 68.45

Gene sequence:

>1065_bases
ATGACTGCCTCGAACGCTTCTTCCCCGGCGACGCTCTCGCTCGCCCGTCCCGACGACTGGCACCTGCACCTGCGAGACGG
CGACATGCTGGCCGCCGTGCTGCCGCACACCGCACGCCAGTTCGGCCGTGCAATCGTCATGCCGAACCTGAAGCCGCCGG
TGACGACCACCGCGCAGGCGCAGGCCTATCGCGAGCGCATCCTCGCCGCGCTGCCGGCCGGGATGACGTTCGAACCGCTG
ATGACGCTGTACCTGACCGACAACACGCCGCCCGACGAGATCCGCCGCGCGCGCGAAAGCGGCTTCGTGCACGGCGTGAA
GCTGTATCCGGCCGGCGCGACGACGAATTCCGACCACGGCGTCACCGATCTCGCGAAATGCGCGAAGACGCTCGAGGCGA
TGCAGGAAACTGGCATGCCGCTGCTGGTGCACGGCGAAGTGACCGATGCGTCGATCGACCTGTTCGACCGCGAGAAGGTC
TTCATCGACCGCGTGATGACGCCGCTGCGCCGCGATTTCCCGGGCCTGAAGGTCGTGTTCGAACACATCACGACGAAGGA
TGCGGCCGACTACGTGCGCGACGCCGACGCGGCGCCCGGCCTGCTCGGCGCGACGATCACCGCGCATCACCTGCTGTACA
ACCGCAATGCGCTGTTCGTCGGCGGGATTCGCCCGCATTACTACTGCCTGCCGGTGCTGAAGCGCGAGACGCATCGCGTC
GCGCTCGTCGAGGCCGCGACGTCGGGCAACCCGCGCTTCTTCCTCGGTACCGACAGCGCGCCGCATGCGCGCGACGCGAA
GGAAACCGCGTGCGGCTGCGCGGGCTGCTACACGGCGCTGCATGCGCTCGAACTGTATGCGGAAGCGTTCGACACGGCCG
GCGCGCTCGACAAGCTGGAAGGCTTCGCGAGCTTCTTCGGCGCCGATTTCTACGGGCTGCCGCGCAGCGCCGAGACGGTC
ACGCTGCGTCGCGAGGCATGGGAGCTGCCGCGCGAGATCTTCGCAGGCGATACGCCCGTCGTGCCGCTGCGCGGCGGCGA
GACGATCGGCTGGAAACTGGCGTGA

Upstream 100 bases:

>100_bases
CGCTGGCCAAAGGCCCCGTGTTGCGGTTTGCCGTCAGTCGGCCCGCGGCACGCGTGTTCCGGCCCCGCCGACGGCCAGCC
CGTTCCTCACGACGCCTCCT

Downstream 100 bases:

>100_bases
CGGTCGCACCGCCGAGCGCGCCCGGCCACACGGCCGGCCGCGCTCGGTGCTAGAATGCGCGTCGCAAAGCAGGCCAGGCA
GTCGCGGCCTCGCCGCCTTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPL
MTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKV
FIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
ALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLEGFASFFGADFYGLPRSAETV
TLRREAWELPREIFAGDTPVVPLRGGETIGWKLA

Sequences:

>Translated_354_residues
MTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPL
MTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKV
FIDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
ALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLEGFASFFGADFYGLPRSAETV
TLRREAWELPREIFAGDTPVVPLRGGETIGWKLA
>Mature_353_residues
TASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQAQAYRERILAALPAGMTFEPLM
TLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHGVTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKVF
IDRVMTPLRRDFPGLKVVFEHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRVA
LVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLEGFASFFGADFYGLPRSAETVT
LRREAWELPREIFAGDTPVVPLRGGETIGWKLA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=56.8513119533528, Blast_Score=394, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=35.9550561797753, Blast_Score=192, Evalue=5e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38586; Mature: 38455

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQA
CCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHH
QAYRERILAALPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHG
HHHHHHHHHHCCCCCCHHCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
VTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLRRDFPGLKVVF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEHHCCHHHHHHHHHHHHHHCCCCHHHHH
EHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
HHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHCCCCEE
ALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLE
EEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFASFFGADFYGLPRSAETVTLRREAWELPREIFAGDTPVVPLRGGETIGWKLA
HHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCEECC
>Mature Secondary Structure 
TASNASSPATLSLARPDDWHLHLRDGDMLAAVLPHTARQFGRAIVMPNLKPPVTTTAQA
CCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCHHH
QAYRERILAALPAGMTFEPLMTLYLTDNTPPDEIRRARESGFVHGVKLYPAGATTNSDHG
HHHHHHHHHHCCCCCCHHCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCC
VTDLAKCAKTLEAMQETGMPLLVHGEVTDASIDLFDREKVFIDRVMTPLRRDFPGLKVVF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEHHCCHHHHHHHHHHHHHHCCCCHHHHH
EHITTKDAADYVRDADAAPGLLGATITAHHLLYNRNALFVGGIRPHYYCLPVLKRETHRV
HHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHCCCCEE
ALVEAATSGNPRFFLGTDSAPHARDAKETACGCAGCYTALHALELYAEAFDTAGALDKLE
EEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFASFFGADFYGLPRSAETVTLRREAWELPREIFAGDTPVVPLRGGETIGWKLA
HHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA