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The map label for this gene is gyaR [H]

Identifier: 78048432

GI number: 78048432

Start: 3269431

End: 3270543

Strand: Reverse

Name: gyaR [H]

Synonym: XCV2876

Alternate gene names: 78048432

Gene position: 3270543-3269431 (Counterclockwise)

Preceding gene: 78048433

Following gene: 78048431

Centisome position: 63.16

GC content: 67.57

Gene sequence:

>1113_bases
ATGTGGGCGAGGTGTCGCCGCGCATTCCCGGTCAGGTCGATGTCTGACGGACGTCGTCCCAGGGTGTGGGTGAGCCAGCC
GCTGTTCGACGATGTCGTCGCGCAGCTGGGCGAGCATTTCGAGCTGACCACCACGCAGCGCGTCAGCGCATATTCGCCGG
CCGAGCTGGCCGCGCAACTGGCACCGTTGGACGGCGCCCTGATCACCCTCAACGAGCGCATCGGCGCGGCCGAAATCGCC
GCCGCGCCGCAGCTGCGCGCCATCGCCAATGTCGGCGTGGGCTACAACAATCTCGACATCGACGCCTTGAGCGCGGCCGG
CATCCTGGCCAGCAACACGCCGGACGTGCTTACCGAAACCACGGCCGATCTCGGCTTTGCGTTGCTGATGGCCACCGCGC
GCCGCATCACCGAATCCGAGCGCTGGCTGCGCGACGGGCAGTGGGGGCAATGGTCGTTCAAGACCATGCTCGGCGCCGAT
ATCCACGGCAGCACGCTCGGCATCCTGGGCATGGGACGCATTGGCCAAGGCATCGCCCGGCGCGGTGCGCACGGTTTCGG
CATGCGCGTGCTGTACCACAACCGCAGCCCGTTGCCGGCCGCTACCGAACAGGCGCTGGGCGCACGGTATGTGGATTTCG
AGACGTTGCTGGCGCAGTCCGATCACCTGGTGCTGGTATTGCCGTACACCAGGGACTCTCACCACATCATCGATGCCGCG
GCGTTGGGCAAGATGCGCGCCACCGCCACGCTGGTGAACATCGCCCGCGGTGGCATCGTCGATGAGCTGGCATTGGCCGA
TGCGCTGGCCAACGGCCGCCTGGCCGGTGCCGGCCTGGATGTCTACGAAGGCGAGCCGCATGTGCGTCCGGAGCTGCTGG
CGCTGAACAACGTGGTGCTCACCCCGCACATCGGCAGCGCCAGCCTGGCCACGCGCCGCGCGATGGTGCAACTGGCGGTG
GACAACCTGATCGCTGCGCTGGGCAAGGGCCCGCATGCCGGCAACCCGCCGAGCGCGCTCAACGCCGATGCAGTTGCCGC
TGCCAAACGTGGCGGCACCGGCGTGGATGCGAAAGAAACCGGCGTCACCGGCAGCATTTCGACCAAACGATAG

Upstream 100 bases:

>100_bases
CACGACCCGTGCGTGGGCATCCGCGCCACCCCGATCGCCGAGGCGATGATGGCGCTGGTGCTGATGGACCAGGCGTTGCG
CCATCGTGCCCAGTGCGGCG

Downstream 100 bases:

>100_bases
GGAACCTCCGCGGCCAGCGTTGGAGGTTCCCCGAACCCAGCGCGCAGTGCTTCCTCATTTCCCCTTTCGATAAAGACAAA
CTCATGAGCAACGAAAACCG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MWARCRRAFPVRSMSDGRRPRVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNERIGAAEIA
AAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLTETTADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGAD
IHGSTLGILGMGRIGQGIARRGAHGFGMRVLYHNRSPLPAATEQALGARYVDFETLLAQSDHLVLVLPYTRDSHHIIDAA
ALGKMRATATLVNIARGGIVDELALADALANGRLAGAGLDVYEGEPHVRPELLALNNVVLTPHIGSASLATRRAMVQLAV
DNLIAALGKGPHAGNPPSALNADAVAAAKRGGTGVDAKETGVTGSISTKR

Sequences:

>Translated_370_residues
MWARCRRAFPVRSMSDGRRPRVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNERIGAAEIA
AAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLTETTADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGAD
IHGSTLGILGMGRIGQGIARRGAHGFGMRVLYHNRSPLPAATEQALGARYVDFETLLAQSDHLVLVLPYTRDSHHIIDAA
ALGKMRATATLVNIARGGIVDELALADALANGRLAGAGLDVYEGEPHVRPELLALNNVVLTPHIGSASLATRRAMVQLAV
DNLIAALGKGPHAGNPPSALNADAVAAAKRGGTGVDAKETGVTGSISTKR
>Mature_370_residues
MWARCRRAFPVRSMSDGRRPRVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQLAPLDGALITLNERIGAAEIA
AAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLTETTADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGAD
IHGSTLGILGMGRIGQGIARRGAHGFGMRVLYHNRSPLPAATEQALGARYVDFETLLAQSDHLVLVLPYTRDSHHIIDAA
ALGKMRATATLVNIARGGIVDELALADALANGRLAGAGLDVYEGEPHVRPELLALNNVVLTPHIGSASLATRRAMVQLAV
DNLIAALGKGPHAGNPPSALNADAVAAAKRGGTGVDAKETGVTGSISTKR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=40.9448818897638, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI23308577, Length=279, Percent_Identity=32.258064516129, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557497, Length=303, Percent_Identity=34.983498349835, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI61743967, Length=303, Percent_Identity=34.983498349835, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI145580578, Length=318, Percent_Identity=34.5911949685535, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4557499, Length=318, Percent_Identity=34.5911949685535, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI145580575, Length=242, Percent_Identity=39.2561983471074, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI87082289, Length=310, Percent_Identity=43.8709677419355, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1787645, Length=265, Percent_Identity=30.9433962264151, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789279, Length=299, Percent_Identity=31.1036789297659, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081824, Length=169, Percent_Identity=34.3195266272189, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=298, Percent_Identity=29.1946308724832, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=315, Percent_Identity=26.031746031746, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=38.0753138075314, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=313, Percent_Identity=29.073482428115, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=307, Percent_Identity=28.3387622149837, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=32, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=272, Percent_Identity=25.3676470588235, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=25.1851851851852, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45552429, Length=324, Percent_Identity=38.2716049382716, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45551003, Length=324, Percent_Identity=38.2716049382716, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574284, Length=324, Percent_Identity=38.2716049382716, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=38.1987577639752, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=38.1987577639752, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28571528, Length=320, Percent_Identity=37.8125, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=42.0849420849421, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=33.201581027668, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19921140, Length=326, Percent_Identity=30.0613496932515, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646446, Length=351, Percent_Identity=30.4843304843305, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24646448, Length=351, Percent_Identity=30.4843304843305, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24646452, Length=351, Percent_Identity=30.4843304843305, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24646450, Length=351, Percent_Identity=30.4843304843305, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI62472511, Length=351, Percent_Identity=30.4843304843305, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 39059; Mature: 39059

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWARCRRAFPVRSMSDGRRPRVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQL
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHH
APLDGALITLNERIGAAEIAAAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLTET
CCCCCEEEEECCCCCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCEEECCCCHHHHHH
TADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRIGQGIAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCHHHHHHHH
RGAHGFGMRVLYHNRSPLPAATEQALGARYVDFETLLAQSDHLVLVLPYTRDSHHIIDAA
CCCCCCEEEEEEECCCCCCHHHHHHHCCEECCHHHHHCCCCCEEEEEECCCCCCCEEHHH
ALGKMRATATLVNIARGGIVDELALADALANGRLAGAGLDVYEGEPHVRPELLALNNVVL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCCCCEEEECCEEE
TPHIGSASLATRRAMVQLAVDNLIAALGKGPHAGNPPSALNADAVAAAKRGGTGVDAKET
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHC
GVTGSISTKR
CCCCCCCCCC
>Mature Secondary Structure
MWARCRRAFPVRSMSDGRRPRVWVSQPLFDDVVAQLGEHFELTTTQRVSAYSPAELAAQL
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHH
APLDGALITLNERIGAAEIAAAPQLRAIANVGVGYNNLDIDALSAAGILASNTPDVLTET
CCCCCEEEEECCCCCHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHCCEEECCCCHHHHHH
TADLGFALLMATARRITESERWLRDGQWGQWSFKTMLGADIHGSTLGILGMGRIGQGIAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCHHHHHHHH
RGAHGFGMRVLYHNRSPLPAATEQALGARYVDFETLLAQSDHLVLVLPYTRDSHHIIDAA
CCCCCCEEEEEEECCCCCCHHHHHHHCCEECCHHHHHCCCCCEEEEEECCCCCCCEEHHH
ALGKMRATATLVNIARGGIVDELALADALANGRLAGAGLDVYEGEPHVRPELLALNNVVL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEECCCCEEECCCCCCCCCEEEECCEEE
TPHIGSASLATRRAMVQLAVDNLIAALGKGPHAGNPPSALNADAVAAAKRGGTGVDAKET
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHC
GVTGSISTKR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA