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The map label for this gene is nuoD [H]

Identifier: 78048406

GI number: 78048406

Start: 3243672

End: 3244979

Strand: Reverse

Name: nuoD [H]

Synonym: XCV2850

Alternate gene names: 78048406

Gene position: 3244979-3243672 (Counterclockwise)

Preceding gene: 78048407

Following gene: 78048405

Centisome position: 62.66

GC content: 60.78

Gene sequence:

>1308_bases
GTGAGTGAGTTCCGCCAGGCAACCGATGCCTTCGCGAGCAATCCTGTCGAAAGCAAGCAGGAAATCCGCAATTACACGAT
GAACTTCGGCCCGCAGCATCCTGCGGCGCACGGCGTGTTGCGCCTGATCCTGGAAATGGATGGCGAGACCGTGGTGCGTG
CCGATCCGCATATCGGCCTGCTGCACCGTGGCACCGAGAAGCTGGCCGAGTCCAAGCCGTTCAACCAGTCGGTTCCGTAC
ATGGATCGTCTGGATTACGTCTCGATGATGTGCAACGAGCACGCCTATGTGCGCGCGATCGAATCCCTGATGGGGATCGA
AGCACCCGAGCGTGCGCAGTACATCCGCACCATGTTCGACGAGATCACCCGCATCAAGAACCATTTGATGTGGGTCGGTT
CCAATGCGCTCGATCTGGGTGCGATGGCGGTGATGCTGTATGCATTCCGCGAGCGCGAAGAACTGATGGACGTCTACGAG
GCGGTCAGTGGCGCGCGCATGCACGCGGCCTACTACCGTCCCGGCGGCGTCTACCGCGATCTACCCGATCGCATGCCGCA
GTACAAGGAGTCGCGTTGGCACAAGGGCGGGGCGCTGAAGAAGCGCAATGCCGGTCGCGAAGGCACCATGCTGGACTTCC
TCGAGGAGTTCACCAATACCTTCCCGGCACGCGTGGACGAGTACGAGACCCTGCTGACCGATAACCGCATCTGGAAGCAG
CGTACCGTCGACGTCGGCATAATCAGCCCGGATCTGGCACGCGCCTGGGGCATGACCGGTCCGATGTTGCGTGGCTCGGG
CATCGAGTGGGATCTGCGCAAGAAGCAGCCCTACGCCAAGTACGACGCGGTGGATTTCGATATCCCCGTCGGCACCAACG
GCGACTGCTATGACCGCTACCTGGTGCGCGTGGCCGAGATGCGCGAATCCAACCGCATCATCAAACAGTGCGTGAAGTGG
CTGAAGGCCAACCCGGGCCCGGTCATGGTCACCAATTTCAAGGTCGCTCCGCCCAGCCGAGAAGGCATGAAGGACGACAT
GGAAGCGCTGATCCATCACTTCAAGCTGTTCAGTGAAGGCTATTGCGTGCCGGCCGGCGAAACCTATAGCGCGGTGGAAG
CACCCAAGGGCGAGTTCGGTTGCTACTTGATGTCCGACGGCGCCAACAAGCCGTTCCGCGTGCATCTGCGCGCGCCGGGT
TTTGCGCATCTGTCGTCGATGGATGCGGTGGTGCGTGGCTATTTGCTGGCCGACGTCGTGGCGATGATCGGTACTTACGA
TTTGGTTTTCGGTGAGGTTGACCGATGA

Upstream 100 bases:

>100_bases
TGACCTCGGTCGAGCCGCGCGTCGGCGTGCCGCGCGTCATTCGCGACGATGCCCGTTATGAGACTGCCGCTGGTGAAGTG
GGCAAGTCGGAGACTGCCAA

Downstream 100 bases:

>100_bases
AGGCGACGGGTAATTTCGAAGCGGCGCGCGACGTCGATCCGCAGGTGGTGCTGAGCGACAAGACGCGCGCGCACATCGAT
CACTGGCTGACCAAGTTCCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSEFRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPY
MDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYE
AVSGARMHAAYYRPGGVYRDLPDRMPQYKESRWHKGGALKKRNAGREGTMLDFLEEFTNTFPARVDEYETLLTDNRIWKQ
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKW
LKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPG
FAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR

Sequences:

>Translated_435_residues
MSEFRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPY
MDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYE
AVSGARMHAAYYRPGGVYRDLPDRMPQYKESRWHKGGALKKRNAGREGTMLDFLEEFTNTFPARVDEYETLLTDNRIWKQ
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKW
LKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPG
FAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR
>Mature_434_residues
SEFRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPYM
DRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEA
VSGARMHAAYYRPGGVYRDLPDRMPQYKESRWHKGGALKKRNAGREGTMLDFLEEFTNTFPARVDEYETLLTDNRIWKQR
TVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKWL
KANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPGF
AHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=57.2463768115942, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=56.3725490196078, Blast_Score=472, Evalue=1e-133,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.2926829268293, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1789076, Length=439, Percent_Identity=26.879271070615, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788832, Length=407, Percent_Identity=26.7813267813268, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17555284, Length=431, Percent_Identity=52.6682134570766, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17568379, Length=419, Percent_Identity=52.5059665871122, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24638644, Length=422, Percent_Identity=58.0568720379147, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221459469, Length=414, Percent_Identity=54.1062801932367, Blast_Score=463, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49446; Mature: 49315

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGL
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCH
LHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFD
HHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
EITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRD
HHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCC
LPDRMPQYKESRWHKGGALKKRNAGREGTMLDFLEEFTNTFPARVDEYETLLTDNRIWKQ
CHHHCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRY
HCCEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHH
LVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
YCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVV
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AMIGTYDLVFGEVDR
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEFRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGL
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCH
LHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFD
HHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
EITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRD
HHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCC
LPDRMPQYKESRWHKGGALKKRNAGREGTMLDFLEEFTNTFPARVDEYETLLTDNRIWKQ
CHHHCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRY
HCCEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHH
LVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
YCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVV
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AMIGTYDLVFGEVDR
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]