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The map label for this gene is nuoE [H]

Identifier: 78048405

GI number: 78048405

Start: 3243148

End: 3243675

Strand: Reverse

Name: nuoE [H]

Synonym: XCV2849

Alternate gene names: 78048405

Gene position: 3243675-3243148 (Counterclockwise)

Preceding gene: 78048406

Following gene: 78048404

Centisome position: 62.64

GC content: 62.12

Gene sequence:

>528_bases
ATGAAGGCGACGGGTAATTTCGAAGCGGCGCGCGACGTCGATCCGCAGGTGGTGCTGAGCGACAAGACGCGCGCGCACAT
CGATCACTGGCTGACCAAGTTCCCGCCGGACCGCAAGCGTTCGGCGGTGCTGCAGGGTCTGCACGCCGCGCAAGAGCAGA
ACCAGGGCTGGCTGACCGACGAATTGATCGTGGGCGTAGCCAAGTACCTGGAGCTGCCGCCGGTATGGGCTTATGAGGTC
GCCAGCTTTTACTCGATGTTCGAGACCGAACGCGTCGGCCGCCATAACGTGGCGTTCTGCACCAATATCAGCTGCTGGCT
CAATGGCGCCGAGGATCTGCTGGCCCACGCGGAAAAGAAGCTGGGTTGCAAGCTGGGGCAGTCGACGGCCGATGGTCGCG
TCTACCTCAAGCGCGAAGAAGAGTGCCTGGCTGCCTGCTCCGCGGCGCCGATGATGGTCATCAATGGCCACTATCACGAG
CATCTGACGAAAGAAAAGGTCGACGCGCTGCTGGACGGGCTGGAGTAA

Upstream 100 bases:

>100_bases
CGCATCTGTCGTCGATGGATGCGGTGGTGCGTGGCTATTTGCTGGCCGACGTCGTGGCGATGATCGGTACTTACGATTTG
GTTTTCGGTGAGGTTGACCG

Downstream 100 bases:

>100_bases
GACATGGCACATCATCACGCACCCTCAGGCCCGGTCGGTCCGGCGCCGCAGCCGCATCAGGTCGTCTACACGACCCTGCA
CTATGACACTCCGTGGTCGT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MKATGNFEAARDVDPQVVLSDKTRAHIDHWLTKFPPDRKRSAVLQGLHAAQEQNQGWLTDELIVGVAKYLELPPVWAYEV
ASFYSMFETERVGRHNVAFCTNISCWLNGAEDLLAHAEKKLGCKLGQSTADGRVYLKREEECLAACSAAPMMVINGHYHE
HLTKEKVDALLDGLE

Sequences:

>Translated_175_residues
MKATGNFEAARDVDPQVVLSDKTRAHIDHWLTKFPPDRKRSAVLQGLHAAQEQNQGWLTDELIVGVAKYLELPPVWAYEV
ASFYSMFETERVGRHNVAFCTNISCWLNGAEDLLAHAEKKLGCKLGQSTADGRVYLKREEECLAACSAAPMMVINGHYHE
HLTKEKVDALLDGLE
>Mature_175_residues
MKATGNFEAARDVDPQVVLSDKTRAHIDHWLTKFPPDRKRSAVLQGLHAAQEQNQGWLTDELIVGVAKYLELPPVWAYEV
ASFYSMFETERVGRHNVAFCTNISCWLNGAEDLLAHAEKKLGCKLGQSTADGRVYLKREEECLAACSAAPMMVINGHYHE
HLTKEKVDALLDGLE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=149, Percent_Identity=38.9261744966443, Blast_Score=117, Evalue=8e-27,
Organism=Escherichia coli, GI1788621, Length=154, Percent_Identity=36.3636363636364, Blast_Score=94, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17561328, Length=157, Percent_Identity=39.4904458598726, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859877, Length=179, Percent_Identity=35.195530726257, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355353, Length=156, Percent_Identity=31.4102564102564, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19594; Mature: 19594

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKATGNFEAARDVDPQVVLSDKTRAHIDHWLTKFPPDRKRSAVLQGLHAAQEQNQGWLTD
CCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHH
ELIVGVAKYLELPPVWAYEVASFYSMFETERVGRHNVAFCTNISCWLNGAEDLLAHAEKK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCHHHHHHHHHHH
LGCKLGQSTADGRVYLKREEECLAACSAAPMMVINGHYHEHLTKEKVDALLDGLE
HHHHCCCCCCCCEEEEECHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKATGNFEAARDVDPQVVLSDKTRAHIDHWLTKFPPDRKRSAVLQGLHAAQEQNQGWLTD
CCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHH
ELIVGVAKYLELPPVWAYEVASFYSMFETERVGRHNVAFCTNISCWLNGAEDLLAHAEKK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCHHHHHHHHHHH
LGCKLGQSTADGRVYLKREEECLAACSAAPMMVINGHYHEHLTKEKVDALLDGLE
HHHHCCCCCCCCEEEEECHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA