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The map label for this gene is yveA [H]

Identifier: 78048295

GI number: 78048295

Start: 3116123

End: 3117709

Strand: Reverse

Name: yveA [H]

Synonym: XCV2739

Alternate gene names: 78048295

Gene position: 3117709-3116123 (Counterclockwise)

Preceding gene: 78048296

Following gene: 78048294

Centisome position: 60.21

GC content: 64.46

Gene sequence:

>1587_bases
ATGACCACACACGCTGCGACCACGCAAGGCAAGTTCCACAAGCGCCTCAGCCTCACCGACCTGACCTTTATCGGGCTGGG
TTCGATCTTCGGTTCCGGGTGGTTGTTTTCGGCCAGCCACGTCTCATCGATCGCGGGGCCGGCCGGCATCGTGTCGTGGA
TACTCGGCGGTATCGCGGTGCTGCTGCTTGGGCTGGTGTATTGCGAACTCGGCGCGGCATTGCCGCGCGCCGGCGGAGTG
GTGCGCTACCCGGAGTATTCGCATGGCGCCTTGCTCGGTTCGTTGACCGGCTTCATCACCTTGATCGCATTCTCCAGCCT
GATCGCGATCGAAGTGGAGGCGGCGCGGCAATACGCAGCGGCGTGGTTCCCGTGGTTGAGCCAGCCGCACAGCACCCATC
CCAGCGTGGCGGGTTGGCTGGTGCAGTTGGCCTTGCTGGTGCTGTTCTTCGTACTCAACTATTTCAGCGTCAAGACCTTC
GCGCTGGCCAACAACATCGTCAGCATCTTCAAGTTTCTGGTGCCGATCCTGGTGATCGTGCTGCTGATGCAGCACTTCGA
TGCCGGCAATCTGAGCGTGCATGGGTTCGCGCCCTCTGGCATGGCCGGTGTGGAAGCAGCGATCTCGGCCGGCGGCATCA
TCTTCGCGTATCTGGGGTTGACGCCGATCGTGTCGGTGGCCAGTGAGGTGCGCGACCCGCAGCGCAATATTCCGATTGCG
CTGATCCTGTCGGTGGCGCTGTCCACGGTGATTTACGTGCTGCTGCAGCTGGCGTTCCTGGGCAGCATCCCGGCCGCGCA
GCTCGCGCAAGGCTGGGCGTGCATCGACAAGGCCTTCTCGCTGCCGTATCACGACATCGCCCTGGCCTTGGGCATGGCGT
GGCTGGCTGCGCTGGTGATCTGCGATGCGATGGTCTCGCCCAGCGGCACCGGCAACATCTACATGAATGCCACGCCGCGC
GTGGTGTACGGCTGGGCGCGCAGTGGCGGGTTCTTGCCGGTGCTGACGCGGGTGGACCCGGCTTCGGGTATCCCGCGTCC
GGCACTGTGGTTGAGCCTGGGGTTGTCGATCTTCTGGACGCTGCCGTTCCCCTCGTGGGAAACGCTGATCGGGGTGGTGT
CGGCCGCCTTGGTGCTGAGCTATGCGGTGGCGCCGATCACGGTGGCGGCCCTGCGCCGCAGCGCGCCGGACTTGCCACGC
CCATTTTTCGTGCGTGGCCTGCCGGTGATGGGGCCGCTGTCGTTCATGGTTGCGGCGTTGATCGTGTACTGGTCCACCTG
GCCGACCTTGTCGTGGTTGCTCGGCTTGCAGGTGCTGGCGTTCGTGCTGTACGTGCTATTTCGCCTGCCTTTGCGCCAGG
GCCGCGCGCGCCTGGTGCGGCAGGTACGCGCGTCGCTGTGGCTGATCGTGTTCTTCGTGCTGGTGATGCTGGTGTCGTGG
GCGGGCACGTTCGGTGGACATGGCTGGATTGCGCATCCCTTCGATACGTTGAGCGTGGCGGTCATCGCGTTCTGCATCTA
TCACTGGGGCGCACGCAGCGGTTTGCGCAGCGACGAGCTTGCGCTGGAGGAGGACGATGGTGAGTGA

Upstream 100 bases:

>100_bases
AGGCATCGGCAGAGGCGAAGGCCTCTGCCAGCGACTGACACGTGCGCGCACGTGATGCTCTAATTGCAGTAACCGCGCTT
TCCACACTTCGGGGCGACGT

Downstream 100 bases:

>100_bases
TGCGCGCCGCCGCGCATTTGGTTTGCGTCGATGGTCTGCGCTGGCCGGGTACATGATGGTGTTGTCGGGTGCTGTGCAGG
CTGCGCCCAGCGTTGCCGAT

Product: amino acid-polyamine-organocation superfamily protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGV
VRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPWLSQPHSTHPSVAGWLVQLALLVLFFVLNYFSVKTF
ALANNIVSIFKFLVPILVIVLLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDPQRNIPIA
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWACIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPR
VVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPR
PFFVRGLPVMGPLSFMVAALIVYWSTWPTLSWLLGLQVLAFVLYVLFRLPLRQGRARLVRQVRASLWLIVFFVLVMLVSW
AGTFGGHGWIAHPFDTLSVAVIAFCIYHWGARSGLRSDELALEEDDGE

Sequences:

>Translated_528_residues
MTTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGV
VRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPWLSQPHSTHPSVAGWLVQLALLVLFFVLNYFSVKTF
ALANNIVSIFKFLVPILVIVLLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDPQRNIPIA
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWACIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPR
VVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPR
PFFVRGLPVMGPLSFMVAALIVYWSTWPTLSWLLGLQVLAFVLYVLFRLPLRQGRARLVRQVRASLWLIVFFVLVMLVSW
AGTFGGHGWIAHPFDTLSVAVIAFCIYHWGARSGLRSDELALEEDDGE
>Mature_527_residues
TTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGVV
RYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPWLSQPHSTHPSVAGWLVQLALLVLFFVLNYFSVKTFA
LANNIVSIFKFLVPILVIVLLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDPQRNIPIAL
ILSVALSTVIYVLLQLAFLGSIPAAQLAQGWACIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPRV
VYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPRP
FFVRGLPVMGPLSFMVAALIVYWSTWPTLSWLLGLQVLAFVLYVLFRLPLRQGRARLVRQVRASLWLIVFFVLVMLVSWA
GTFGGHGWIAHPFDTLSVAVIAFCIYHWGARSGLRSDELALEEDDGE

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=437, Percent_Identity=24.4851258581236, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7657591, Length=437, Percent_Identity=24.4851258581236, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4507047, Length=435, Percent_Identity=23.6781609195402, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI33286428, Length=404, Percent_Identity=25.4950495049505, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI186910308, Length=421, Percent_Identity=24.2280285035629, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI186910306, Length=421, Percent_Identity=24.2280285035629, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI186910304, Length=421, Percent_Identity=24.2280285035629, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI110347453, Length=359, Percent_Identity=25.3481894150418, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258614005, Length=434, Percent_Identity=22.8110599078341, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI258614003, Length=434, Percent_Identity=22.1198156682028, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI71979932, Length=428, Percent_Identity=24.7663551401869, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI258645169, Length=380, Percent_Identity=22.6315789473684, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI115648063, Length=424, Percent_Identity=21.9339622641509, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI115648022, Length=424, Percent_Identity=21.9339622641509, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790653, Length=384, Percent_Identity=23.9583333333333, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788480, Length=361, Percent_Identity=24.9307479224377, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786789, Length=415, Percent_Identity=24.0963855421687, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786602, Length=351, Percent_Identity=25.3561253561254, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI2367353, Length=345, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=21.1442786069652, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786302, Length=401, Percent_Identity=22.1945137157107, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082250, Length=358, Percent_Identity=24.8603351955307, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=426, Percent_Identity=25.1173708920188, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532491, Length=415, Percent_Identity=26.5060240963855, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531343, Length=454, Percent_Identity=25.9911894273128, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17568033, Length=415, Percent_Identity=24.578313253012, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17533459, Length=413, Percent_Identity=23.728813559322, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667468, Length=405, Percent_Identity=25.679012345679, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651635, Length=413, Percent_Identity=24.2130750605327, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651633, Length=413, Percent_Identity=24.2130750605327, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221512776, Length=427, Percent_Identity=22.7166276346604, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666159, Length=427, Percent_Identity=22.7166276346604, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45550968, Length=418, Percent_Identity=25.3588516746411, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921172, Length=418, Percent_Identity=25.3588516746411, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357367, Length=419, Percent_Identity=24.1050119331742, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221331183, Length=367, Percent_Identity=25.0681198910082, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647653, Length=367, Percent_Identity=25.0681198910082, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664379, Length=367, Percent_Identity=25.0681198910082, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641995, Length=397, Percent_Identity=24.6851385390428, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641993, Length=397, Percent_Identity=24.6851385390428, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56742; Mature: 56610

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAV
CCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHH
LLLGLVYCELGAALPRAGGVVRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWFPWLSQPHSTHPSVAGWLVQLALLVLFFVLNYFSVKTFALANNIVSIFKFLVPILVIV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDPQRNIPIA
HHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWACIDKAFSLPYHDIALALGMAWLAALVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
CDAMVSPSGTGNIYMNATPRVVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWT
HHHHCCCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHEEE
LPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPRPFFVRGLPVMGPLSFMVAAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHH
IVYWSTWPTLSWLLGLQVLAFVLYVLFRLPLRQGRARLVRQVRASLWLIVFFVLVMLVSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFGGHGWIAHPFDTLSVAVIAFCIYHWGARSGLRSDELALEEDDGE
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTHAATTQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAV
CCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHH
LLLGLVYCELGAALPRAGGVVRYPEYSHGALLGSLTGFITLIAFSSLIAIEVEAARQYAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWFPWLSQPHSTHPSVAGWLVQLALLVLFFVLNYFSVKTFALANNIVSIFKFLVPILVIV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMQHFDAGNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRDPQRNIPIA
HHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWACIDKAFSLPYHDIALALGMAWLAALVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
CDAMVSPSGTGNIYMNATPRVVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWT
HHHHCCCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHEEE
LPFPSWETLIGVVSAALVLSYAVAPITVAALRRSAPDLPRPFFVRGLPVMGPLSFMVAAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHH
IVYWSTWPTLSWLLGLQVLAFVLYVLFRLPLRQGRARLVRQVRASLWLIVFFVLVMLVSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFGGHGWIAHPFDTLSVAVIAFCIYHWGARSGLRSDELALEEDDGE
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]