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The map label for this gene is ptpA [H]

Identifier: 78048282

GI number: 78048282

Start: 3094756

End: 3096576

Strand: Reverse

Name: ptpA [H]

Synonym: XCV2726

Alternate gene names: 78048282

Gene position: 3096576-3094756 (Counterclockwise)

Preceding gene: 78048283

Following gene: 78048281

Centisome position: 59.8

GC content: 65.18

Gene sequence:

>1821_bases
ATGGCCGCTGGCGTGCCTGGGTGGAGCAGGGCAATCTGGTCATCGCGCCGGTTGGCAGTCACGAGCGCAGCGTGCTCAGC
CACGACGGCAGCACGGATGACTACTACGCACTCGACAGCGTGGTGTGGTCGCCGGATTCGCAGCATCTGGCGGCATATCG
GGGTCAAGGCACCGCCGCCGCGCATGGTCTATTACATCGAGTCGGCGCCCACCGATCAGGTGCAGCCGAAGTTGCATCAG
CAGGTCTACCCCAAGCCAGGCGATGCGTTGCCGGTGATGCAGCCGGTCTTGTTCGATCTCGCCACGCACGCAGCGCATCC
GGTGGCGATGACCTTGCTGCCCAATGCCTTCACCTTGAGCGAAATGGTCTGGTGGAAGGACAGTCGCGGTTTCACCTTCG
AATACAACGCACGCGGTCACCAGCTGTACCGGGTGATCGAGGTGGATGCACGCACAGCCGCCGCGCGCACGCTGATCGAA
GAGACATCGCCCACCTTCATCGAATACTCCGAGCTCAGTGGCGAGCATGAGAACGGCGGCAAGCACGCACGCCAGGATCT
GGACGATGGCGCGCAGATCGTGTGGGCATCCGAGCGCGATGGCTGGGAGCATCTGTATCTGTACGACGGCCACAACGGCG
AGGTGATTCGCCAGGTCACCCGTGGCGACTGGGTGGTGCGCAAGCTCGATCGCATCGACCAAGCAGCGGGGCAGGTGTAT
TTCACCGCCTCGGGTATGCAGCCCGGCGAGGACCCGTACTATCGCCATGCCTATCGCATCGGGCTGGATGGCCGCGGGCT
TACCGCATTGACGCCGCTGGCTGCCGATCATGAGGTGCGCTATTCGCCGGATGGAACCTGGCTATTGGATCTTTACTCGC
GCGTGGATCTGGGCCCGGTGCTGGAGTTGCGGCGCAGCGCAGATGGCAGCCTGGCACGCACGGTGGAGCGCACCGACCTG
ACCCGCCTGCTGGCGGCAGGGTGGCAGGCGCCGCTGCCGTTTCACACCACCGGGCGCGACGGCAGGACCGAGATCTGGGG
CGTCATCCATCGCCCGCAGCAGCTCGATCCGCAGCAGCGCTACCGGGTCGTCGAAGACATCTATGCCGGACCGCAAGGCT
CGTTCGTTCCCAAGAGCTTTAGCACCGCCACACCATCGCTCACCGGGATGGGGTTTGCGGTAGCGTCCATCGATGGCATG
GGCACCAACAACCGCTCGCGCGCCTTCCACGATGTGGCCTGGCGCAACCTCAAGGACGCCGGGTTGCCGGATCGTATCGC
CTGGCACAAGGCAGCCGCGGCGCACTACCCGTGGTACGACATCGGCGGCGGTGTCGGTGTGTACGGCACCTCGGCAGGCG
GGCAGAACGCGTTGGGGGCGCTGCTGTTTCATCCGGAGTTCTATGTGGCGGGTGTGGCCAATTCCGGCTGCCACGACAAC
CGCATGGACAAGATCTGGTGGAACGAACAGTGGATGGGCTGGCCGGTCGGCCCGTGGTACGCCGCATCGTCGAATGTGGA
GAACGCCGCGCGCCTGCAGGGGCATCTGTTGCTGGTCACCGGCGACATGGACATGAATGTCGACCCGGCCAGTACCTTCC
AGGTGGCCGACCGCCTGATCAAGGCTGGCAAGGATTTCGATCTGCTGGTCGTGCCGGGCGGCGATCACGGTGCCGGTGGC
GACTACGGCAGGCGCCGCCTGCTGGATTTCTTCCTGCGCTGGATGCAGCAGGCACCAACGCCTGAGTGGAATCGCAACGT
CGCAGCGCCGGCCGCATCGGTGCGGTCATGCGCGCGCTGCCGGTCGCGTGCAGCGAGTTGA

Upstream 100 bases:

>100_bases
TATCGCTGCGCGCACCTGCCCGAACGCGACCTGCCGGCCGAATCGATGGACATGCGCCTGCCGCTCAAGCAGGGCGAACG
CCAGGCCAGGACATCGCCGG

Downstream 100 bases:

>100_bases
CGTGCGCGGCACATCGGGCCCAATGCCCCCGTCCGCGCATCGATCGTGGTCAGCTTCATCTGCACTCCAATCGCCGCAAG
CGGTGCCAATGCGTGCGAGC

Product: putative peptidase (C-terminal fragment)

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MAAGVPGWSRAIWSSRRLAVTSAACSATTAARMTTTHSTAWCGRRIRSIWRHIGVKAPPPRMVYYIESAPTDQVQPKLHQ
QVYPKPGDALPVMQPVLFDLATHAAHPVAMTLLPNAFTLSEMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIE
ETSPTFIEYSELSGEHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGHNGEVIRQVTRGDWVVRKLDRIDQAAGQVY
FTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGTWLLDLYSRVDLGPVLELRRSADGSLARTVERTDL
TRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQRYRVVEDIYAGPQGSFVPKSFSTATPSLTGMGFAVASIDGM
GTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAAHYPWYDIGGGVGVYGTSAGGQNALGALLFHPEFYVAGVANSGCHDN
RMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQVADRLIKAGKDFDLLVVPGGDHGAGG
DYGRRRLLDFFLRWMQQAPTPEWNRNVAAPAASVRSCARCRSRAAS

Sequences:

>Translated_606_residues
MAAGVPGWSRAIWSSRRLAVTSAACSATTAARMTTTHSTAWCGRRIRSIWRHIGVKAPPPRMVYYIESAPTDQVQPKLHQ
QVYPKPGDALPVMQPVLFDLATHAAHPVAMTLLPNAFTLSEMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIE
ETSPTFIEYSELSGEHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGHNGEVIRQVTRGDWVVRKLDRIDQAAGQVY
FTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGTWLLDLYSRVDLGPVLELRRSADGSLARTVERTDL
TRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQRYRVVEDIYAGPQGSFVPKSFSTATPSLTGMGFAVASIDGM
GTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAAHYPWYDIGGGVGVYGTSAGGQNALGALLFHPEFYVAGVANSGCHDN
RMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQVADRLIKAGKDFDLLVVPGGDHGAGG
DYGRRRLLDFFLRWMQQAPTPEWNRNVAAPAASVRSCARCRSRAAS
>Mature_605_residues
AAGVPGWSRAIWSSRRLAVTSAACSATTAARMTTTHSTAWCGRRIRSIWRHIGVKAPPPRMVYYIESAPTDQVQPKLHQQ
VYPKPGDALPVMQPVLFDLATHAAHPVAMTLLPNAFTLSEMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIEE
TSPTFIEYSELSGEHENGGKHARQDLDDGAQIVWASERDGWEHLYLYDGHNGEVIRQVTRGDWVVRKLDRIDQAAGQVYF
TASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGTWLLDLYSRVDLGPVLELRRSADGSLARTVERTDLT
RLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQRYRVVEDIYAGPQGSFVPKSFSTATPSLTGMGFAVASIDGMG
TNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAAHYPWYDIGGGVGVYGTSAGGQNALGALLFHPEFYVAGVANSGCHDNR
MDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQVADRLIKAGKDFDLLVVPGGDHGAGGD
YGRRRLLDFFLRWMQQAPTPEWNRNVAAPAASVRSCARCRSRAAS

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI194394146, Length=381, Percent_Identity=24.4094488188976, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI37577089, Length=359, Percent_Identity=24.7910863509749, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI18450280, Length=359, Percent_Identity=24.7910863509749, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508019, Length=238, Percent_Identity=28.9915966386555, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17508017, Length=238, Percent_Identity=28.9915966386555, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 67203; Mature: 67072

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGVPGWSRAIWSSRRLAVTSAACSATTAARMTTTHSTAWCGRRIRSIWRHIGVKAPPP
CCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCCCC
RMVYYIESAPTDQVQPKLHQQVYPKPGDALPVMQPVLFDLATHAAHPVAMTLLPNAFTLS
CEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
EMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSGEHENGG
HHHEEECCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEHHCCCCCCCCC
KHARQDLDDGAQIVWASERDGWEHLYLYDGHNGEVIRQVTRGDWVVRKLDRIDQAAGQVY
HHHHHCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
FTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGTWLLDLYSRVDLGPV
EEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCEEECCCCCCCEEHHHHCCCCHH
LELRRSADGSLARTVERTDLTRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQR
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCHHHH
YRVVEDIYAGPQGSFVPKSFSTATPSLTGMGFAVASIDGMGTNNRSRAFHDVAWRNLKDA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCC
GLPDRIAWHKAAAAHYPWYDIGGGVGVYGTSAGGQNALGALLFHPEFYVAGVANSGCHDN
CCCCHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCEEEEECCCEEEEECCCCCCCCC
RMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQVADRLI
CCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHH
KAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRNVAAPAASVRSCARC
HCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
RSRAAS
HHHCCC
>Mature Secondary Structure 
AAGVPGWSRAIWSSRRLAVTSAACSATTAARMTTTHSTAWCGRRIRSIWRHIGVKAPPP
CCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCCCC
RMVYYIESAPTDQVQPKLHQQVYPKPGDALPVMQPVLFDLATHAAHPVAMTLLPNAFTLS
CEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
EMVWWKDSRGFTFEYNARGHQLYRVIEVDARTAAARTLIEETSPTFIEYSELSGEHENGG
HHHEEECCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEHHCCCCCCCCC
KHARQDLDDGAQIVWASERDGWEHLYLYDGHNGEVIRQVTRGDWVVRKLDRIDQAAGQVY
HHHHHCCCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
FTASGMQPGEDPYYRHAYRIGLDGRGLTALTPLAADHEVRYSPDGTWLLDLYSRVDLGPV
EEECCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCEEECCCCCCCEEHHHHCCCCHH
LELRRSADGSLARTVERTDLTRLLAAGWQAPLPFHTTGRDGRTEIWGVIHRPQQLDPQQR
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCHHHH
YRVVEDIYAGPQGSFVPKSFSTATPSLTGMGFAVASIDGMGTNNRSRAFHDVAWRNLKDA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCC
GLPDRIAWHKAAAAHYPWYDIGGGVGVYGTSAGGQNALGALLFHPEFYVAGVANSGCHDN
CCCCHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCEEEEECCCEEEEECCCCCCCCC
RMDKIWWNEQWMGWPVGPWYAASSNVENAARLQGHLLLVTGDMDMNVDPASTFQVADRLI
CCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHH
KAGKDFDLLVVPGGDHGAGGDYGRRRLLDFFLRWMQQAPTPEWNRNVAAPAASVRSCARC
HCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
RSRAAS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA