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The map label for this gene is hutU [H]

Identifier: 78047232

GI number: 78047232

Start: 1889781

End: 1891448

Strand: Reverse

Name: hutU [H]

Synonym: XCV1676

Alternate gene names: 78047232

Gene position: 1891448-1889781 (Counterclockwise)

Preceding gene: 78047233

Following gene: 78047231

Centisome position: 36.53

GC content: 66.73

Gene sequence:

>1668_bases
ATGACCCGTCACGATGCAACCCGCGTCATTCGCGCCGCCACCGGCACCACGCTCACCGCCAAGAGCTGGCTCACCGAAGC
GCCGCTGCGCATGTTGATGAACAACCTGGACCCGGACGTGGCCGAGCACCCGCAGGAACTGGTGGTCTACGGCGGTATCG
GCCGCGCCGCGCGCGACTGGGAATCCTTCGACGCCATCGTCGCTGCGCTCACGCGGCTGGACGAGGACCAAACCTTGCTG
GTGCAGTCCGGCAAACCGGTGGGCGTGTTCCGCACCCATGCCGATGCGCCGCGCGTGCTGATCGCCAACTCCAACCTGGT
GCCGCGCTGGGCCAACTGGGACCACTTCAGCGAACTCGATCAAAAGGGCCTGGCCATGTACGGCCAGATGACCGCCGGCA
GCTGGATCTACATCGGCGCGCAAGGCATCGTGCAGGGCACCTACGAAACCTTCGTGGAAATGGGCCGCCAGCACTACGCC
GGCAATCTGGCTGGCAAGTGGCTATTCACCGGCGGTCTCGGCGGCATGGGCGGCGCGCAACCGCTGGCGGCGGTAATGGC
CGGCGCCTCCTGCCTGGTAGTGGAATGCCGCCGCTCCAGCATCGACATGCGCCTGCGTACCGGGTATCTGGATACGTGGA
CCGACTCTCTGGACGAGGCGCTGCGCCTGATCGAGGAGTCGTGCACCGCGAAAAAACCGCTGTCGGTCGGCCTGCTCGGC
AATGTCGCCGACGTGCTGGACGAACTGCTGCTGCGCGGGATCAAGCCGGATCTGTTGACCGACCAGACTTCGGCGCACGA
CCCGGTCAACGGCTACCTGCCGCAGGGCTGGAGCGTGGAAGAGTGGGACGCAAAACGCGTGAGCGCGCGCAAGGAAGTGG
AAGCCGCTGCGCGCGAGTCGATGGCCAACCACATCCGCGCCATGCTCACCTTCCACGCACTGGGCGTGCCTACCGTGGAT
TACGGCAACAACCTGCGCCAGATGGCGCTGGAAGCCGGCATCGACAACGCATTCGATTTCCCCGGCTTCGTGCCTGCCTA
CATCCGCCCGCTGTTCTGTCGCGGCATTGGCCCGTTCCGCTGGGTTGCGCTCAGCGGCGACCCGGACGACATCGCAAAGA
CCGACGCCAAGGTCAAGGAGCTCATCCCCGACGATGCGCACCTGCATCGCTGGCTCGACATGGCGGCCGAAAAGATCGCC
TTCCAGGGCCTGCCCGCGCGCATCTGCTGGGTGGGCCTGGGCGATCGCCACCGGCTGGGCCTGGCCTTCAACGCCATGGT
GCGCAGCGGCGAGCTGAAGGCGCCGGTGGTGATCGGCCGCGACCATCTGGATTCGGGCAGCGTGGCCTCGCCCAATCGCG
AAACCGAAGCGATGGCCGACGGCTCGGACGCGGTCTCCGACTGGCCGCTGCTCAATGCCCTGCTCAACACCGCCAGCGGC
GCCACCTGGGTGTCGCTGCATCACGGCGGCGGCGTCGGCATGGGCTTTTCGCAGCACGCCGGCATGGTCATCGTCTGCGA
CGGCAGCGAGGCCGCCGACAAGCGCATCGAACGCGTGCTCTGGAACGACCCGGCCACCGGGGTGATGCGCCACGCCGATG
CCGGTTACGCCATTGCAACCGATTGCGCGAAGGAAAAAGGGCTGGATTTGCCTGGCATTCTTCGCTGA

Upstream 100 bases:

>100_bases
GTACTGCGCCACGTGCTGCAGGCCTGCCTGCACTTCGCCAATGCGCCCTCCTCCGACACCGCGCCGCCTGCGGCCAACCG
CTGATTGCAAGGAACCCGGC

Downstream 100 bases:

>100_bases
CCCGGCCGAACAGCGCCACGCTTTGGGGGCACCGCTGCAGCATCCGGGCCGCTCCCGCCCGCAGCCTTGTTCATGCATTC
GGCGGTCCCCCGCATGGCCC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAEHPQELVVYGGIGRAARDWESFDAIVAALTRLDEDQTLL
VQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFSELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYA
GNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLVVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTAKKPLSVGLLG
NVADVLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSARKEVEAAARESMANHIRAMLTFHALGVPTVD
YGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIA
FQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRIERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILR

Sequences:

>Translated_555_residues
MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAEHPQELVVYGGIGRAARDWESFDAIVAALTRLDEDQTLL
VQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFSELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYA
GNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLVVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTAKKPLSVGLLG
NVADVLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSARKEVEAAARESMANHIRAMLTFHALGVPTVD
YGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIA
FQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRIERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILR
>Mature_554_residues
TRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAEHPQELVVYGGIGRAARDWESFDAIVAALTRLDEDQTLLV
QSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFSELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAG
NLAGKWLFTGGLGGMGGAQPLAAVMAGASCLVVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTAKKPLSVGLLGN
VADVLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSARKEVEAAARESMANHIRAMLTFHALGVPTVDY
GNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAF
QGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASGA
TWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRIERVLWNDPATGVMRHADAGYAIATDCAKEKGLDLPGILR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=569, Percent_Identity=35.676625659051, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI260306182, Length=214, Percent_Identity=41.1214953271028, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71997891, Length=552, Percent_Identity=35.6884057971014, Blast_Score=319, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60153; Mature: 60022

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAEHPQELVVYGGIGRAARDW
CCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCHHHHH
ESFDAIVAALTRLDEDQTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFSELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHH
QKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAGNLAGKWLFTGGLGGMGGAQ
HHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHH
PLAAVMAGASCLVVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTAKKPLSVGLLG
HHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHH
NVADVLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSARKEVEAAARES
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MANHIRAMLTFHALGVPTVDYGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHH
LAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
HEEEHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRIERVLWNDPATGVMRHADAGYAIAT
CEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEH
DCAKEKGLDLPGILR
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
TRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAEHPQELVVYGGIGRAARDW
CCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCHHHHH
ESFDAIVAALTRLDEDQTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFSELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHH
QKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYAGNLAGKWLFTGGLGGMGGAQ
HHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHH
PLAAVMAGASCLVVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTAKKPLSVGLLG
HHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHH
NVADVLDELLLRGIKPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSARKEVEAAARES
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MANHIRAMLTFHALGVPTVDYGNNLRQMALEAGIDNAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAAEKIAFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHH
LAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
HEEEHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRIERVLWNDPATGVMRHADAGYAIAT
CEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEH
DCAKEKGLDLPGILR
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]