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The map label for this gene is lpd [H]

Identifier: 78047132

GI number: 78047132

Start: 1778138

End: 1779580

Strand: Reverse

Name: lpd [H]

Synonym: XCV1576

Alternate gene names: 78047132

Gene position: 1779580-1778138 (Counterclockwise)

Preceding gene: 78047133

Following gene: 78047131

Centisome position: 34.37

GC content: 65.42

Gene sequence:

>1443_bases
ATGAGCGAACAAGAACAATTCGACGTCGTCGTCATCGGTGCCGGTCCGGCCGGTTATCACGCCGCCATCCGTGCGGCGCA
GCTGGGCATGAAGGTCGCCTGCATCGACGCGGCATTGGGCAAGGACGGCAAGCCGGCGCTGGGCGGCACCTGCCTGCGCG
TGGGCTGCATTCCGTCCAAGGCGCTGCTGGATTCCTCGCGCCAGTTCTGGAACATGGGGCACCTGTTCGGCGACCACGGC
ATCAGCTTCAACGACGCCAAGATGGACGTGCCCACCATGATCGGCCGCAAGGACAAGATCGTGAAGCAGTTCACCGGCGG
CATCGCGATGCTGTTCAAGGCCAACAAGATCACTCCGTACTACGGCTTCGGCCAGTTGCTGCCGGGCAACATCGTCAAGG
TGACCCAGCACGAAGGCGGCGAGATCGAACTCAAGGGCACCAACGTGATCCTGGCGGCCGGTTCGGAGTCGATCGAACTG
CCGTTCGCCAAGTTCGACGGCGACACCATCGTCGACAACGTCGGCGGCCTGGATTTCACCGCCGTTCCCAAGCGTCTGGC
GGTCATCGGCGCCGGCGTGATCGGTCTGGAGCTGGGCAGCGTGTGGAAGCGCCTGGGCGCCGAGGTCACCATCCTCGAGG
CGCTGCCGGACTTCCTGGCGCTGGCCGATGCCGAGGTTGCCAAGACCGCGCTGAAGGAATTCAAGAAGCAGGGTCTGGAC
ATCAAGCTGGGCGCCAAGGTCAGCAAGACCGAGATCACCGGCAGTGGCGATGCCAAGCAGGTGGTGCTCAGCTACACCGA
CGCGGCCGGCGAGCAGACCCTGACCGTGGACAAGTTGCTGGTGGCCGTGGGCCGCAAGGCCGCCACCAAGAACCTGCTGG
CCGAAGGCACGGGCGTCAAGGTCACCGACCGCGGCCAGATCGAGGTCGATGGGCATTGCCACACCGGCGTGGATGGCGTG
TGGGCGATCGGTGACTGCGTGCGCGGCCCGATGCTGGCGCACAAGGGCTTCGAGGAAGGCATCGCGGTGGCGGAGCTGAT
TGCCGGCCTGCCGGGTCACGTCAACTTCGACACCATTCCGTGGGTCATCTACACCGAGCCGGAAATCGCCTGGGTCGGCA
AGACCGAGCAGCAGTTGAAGGCCGAAGGCGTCGCCTACAAGGCCGGCAGCTTCCCGTTCGCAGCGATCGGCCGCGCGGTG
GCCATGGGCGAGCCAGCCGGCTTCGTCAAGGTCATCGCCGATGCCGAAACCGACCGCGTGCTGGGCATGCACTTGGTGGG
CGTGGGCGTGTCCGAGCTGGTGCACGAAGGCGTGCTGACCATGGAGTTCAACGGTTCGGCCGACGACCTGGCGCGCATCT
GCCACGCGCATCCGACGCTGTCCGAAGCGATCCACGATGCCGCCATGGCGGTGAGCAAGCGCGCGATTCATAAGGCTAAC
TGA

Upstream 100 bases:

>100_bases
ATTGGTGATTCGGGATTCGGGATGGCGAAAGCATCCCGGTCTCGAGCATCCTGCGTTTTGCGAATCCCCAATCCCCAATT
CCTAATCTCGTGAGCGAAGA

Downstream 100 bases:

>100_bases
GGCCGGGATTTGGGATTCGGGAGTTGGGATTCGCAACTGCGGTTCCCGCCTCTGACTATTCCCAGCCATGACATAACGCC
GGGTAGATTCCGGCGTTAAG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: E3 component of 2-oxoglutarate dehydrogenase complex; Glycine oxidation system L-factor; LPD-GLC [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSEQEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHLFGDHG
ISFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYGFGQLLPGNIVKVTQHEGGEIELKGTNVILAAGSESIEL
PFAKFDGDTIVDNVGGLDFTAVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLD
IKLGAKVSKTEITGSGDAKQVVLSYTDAAGEQTLTVDKLLVAVGRKAATKNLLAEGTGVKVTDRGQIEVDGHCHTGVDGV
WAIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAV
AMGEPAGFVKVIADAETDRVLGMHLVGVGVSELVHEGVLTMEFNGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN

Sequences:

>Translated_480_residues
MSEQEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHLFGDHG
ISFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYGFGQLLPGNIVKVTQHEGGEIELKGTNVILAAGSESIEL
PFAKFDGDTIVDNVGGLDFTAVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLD
IKLGAKVSKTEITGSGDAKQVVLSYTDAAGEQTLTVDKLLVAVGRKAATKNLLAEGTGVKVTDRGQIEVDGHCHTGVDGV
WAIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAV
AMGEPAGFVKVIADAETDRVLGMHLVGVGVSELVHEGVLTMEFNGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN
>Mature_479_residues
SEQEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSKALLDSSRQFWNMGHLFGDHGI
SFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPYYGFGQLLPGNIVKVTQHEGGEIELKGTNVILAAGSESIELP
FAKFDGDTIVDNVGGLDFTAVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLDI
KLGAKVSKTEITGSGDAKQVVLSYTDAAGEQTLTVDKLLVAVGRKAATKNLLAEGTGVKVTDRGQIEVDGHCHTGVDGVW
AIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIPWVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVA
MGEPAGFVKVIADAETDRVLGMHLVGVGVSELVHEGVLTMEFNGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN

Specific function: Also acts in the glycine cleavage system [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=45.6289978678038, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI50301238, Length=471, Percent_Identity=23.7791932059448, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI22035672, Length=493, Percent_Identity=26.9776876267748, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI33519430, Length=477, Percent_Identity=22.6415094339623, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI33519428, Length=477, Percent_Identity=22.6415094339623, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI33519426, Length=477, Percent_Identity=22.6415094339623, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI148277071, Length=476, Percent_Identity=22.0588235294118, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI148277065, Length=477, Percent_Identity=22.6415094339623, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI291045266, Length=470, Percent_Identity=22.3404255319149, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI291045268, Length=461, Percent_Identity=21.4750542299349, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=40.1709401709402, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI87082354, Length=482, Percent_Identity=29.045643153527, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=28.755364806867, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789915, Length=446, Percent_Identity=25.7847533632287, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=470, Percent_Identity=45.7446808510638, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17557007, Length=498, Percent_Identity=25.1004016064257, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=405, Percent_Identity=25.679012345679, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=405, Percent_Identity=25.679012345679, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=22.6337448559671, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=148, Percent_Identity=30.4054054054054, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=481, Percent_Identity=45.945945945946, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=27.2151898734177, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=22.9957805907173, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=47.7801268498943, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24640549, Length=488, Percent_Identity=25.8196721311475, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640553, Length=488, Percent_Identity=25.8196721311475, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24640551, Length=488, Percent_Identity=25.8196721311475, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17737741, Length=494, Percent_Identity=23.8866396761134, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50436; Mature: 50305

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSK
CCCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCH
ALLDSSRQFWNMGHLFGDHGISFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPY
HHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCCCC
YGFGQLLPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPFAKFDGDTIVDNVGGLDFT
CCCCCCCCCCEEEEEECCCCEEEEECCEEEEEECCCCEECCEEECCCCEEECCCCCCCHH
AVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLD
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IKLGAKVSKTEITGSGDAKQVVLSYTDAAGEQTLTVDKLLVAVGRKAATKNLLAEGTGVK
EEECCEEEEEEECCCCCCCEEEEEEECCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCEE
VTDRGQIEVDGHCHTGVDGVWAIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIP
EECCCEEEECCCCCCCCCCEEEHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
WVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAMGEPAGFVKVIADAETDRV
EEEEECCCEEEECCCHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCE
LGMHLVGVGVSELVHEGVLTMEFNGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN
EEEEEECCCHHHHHHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQEQFDVVVIGAGPAGYHAAIRAAQLGMKVACIDAALGKDGKPALGGTCLRVGCIPSK
CCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCH
ALLDSSRQFWNMGHLFGDHGISFNDAKMDVPTMIGRKDKIVKQFTGGIAMLFKANKITPY
HHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCEEEEEECCCCCCC
YGFGQLLPGNIVKVTQHEGGEIELKGTNVILAAGSESIELPFAKFDGDTIVDNVGGLDFT
CCCCCCCCCCEEEEEECCCCEEEEECCEEEEEECCCCEECCEEECCCCEEECCCCCCCHH
AVPKRLAVIGAGVIGLELGSVWKRLGAEVTILEALPDFLALADAEVAKTALKEFKKQGLD
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IKLGAKVSKTEITGSGDAKQVVLSYTDAAGEQTLTVDKLLVAVGRKAATKNLLAEGTGVK
EEECCEEEEEEECCCCCCCEEEEEEECCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCEE
VTDRGQIEVDGHCHTGVDGVWAIGDCVRGPMLAHKGFEEGIAVAELIAGLPGHVNFDTIP
EECCCEEEECCCCCCCCCCEEEHHHHHCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
WVIYTEPEIAWVGKTEQQLKAEGVAYKAGSFPFAAIGRAVAMGEPAGFVKVIADAETDRV
EEEEECCCEEEECCCHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCE
LGMHLVGVGVSELVHEGVLTMEFNGSADDLARICHAHPTLSEAIHDAAMAVSKRAIHKAN
EEEEEECCCHHHHHHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]